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Comparision between Nonvisualized Finding of 3D-Tof Mrv Cerebral and Cerebral Angiography Result Arif Shidiq1, Anggraini Dwi Sensusiati1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3114

Abstract

Background: Magnetic Resonance Venography (MRV) is a non-invasive method that evaluates the venous system without exposure to the radiation in the procedure compared to cerebral angiography and CT Venography. Nowadays, the use of MRV cerebral started to increase even though there are still many nonvisualized (not visualized vein image) on MRV led to divergent interpretations or noncompliance to the findings of cerebral angiography, which is the gold standard to evaluate venous system. There has been few research comparing MRV findings with cerebral angiography so far. Objective: The aim of this study is to evaluate the findings of non-visualized on MRV compare to cerebral angiography as the gold standard in helping the interpretation of examinations to avoid misdiagnosis. Methods: Observational retrospective analytic study was used in this study that conducted at Husada Utama Surabaya Hospital from October 2013 to February 2014. 39 out of 49 patients selected as samples for fulfilling the inclusion criteria. The observation on the results of MRV and cerebral angiography procedures performed by two specialists of radiology, then the data were analyzed using SPSS. Results: Based on the findings of abnormalities location from 39 samples, we found 35.45% abnormalities in the transverse sinus, 32.91% in the sigmoid sinus, 27.84% in the jugular vein, 2.53% in the straight sinus, and 1.27% in the superior sagittal sinus.The results of comparison between MRV test and cerebral angiography showed compliance at 21% hypoplasia with 88.9% of thrombus. MRV test results with the cause of hypoplasia have100% sensitivity, 67.4% specificity, and 70% accuracy.Meanwhile, we found that 41% sensitivity, 82% specificity, and 50% accuracy because of thrombus. Conclusion: There was significant compliance between 3D-TOF MRV cerebral findings along with cerebral angiography, especially at thrombus.
Decrease of Epstein-Barr Virus Anti Early Antigen Imunoglobulin a Levels and Primary Tumor Size in PostCisplatin-Paclitaxel Chemotherapy in Nasopharyngeal Carcinoma Patients Elvi Syahrina Fiorisa1, Achmad Chusnu Rhomdhoni1, Budi Sutikno1, Anggraini Dwi Sensusiati1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3144

Abstract

Background: Nasopharyngeal carcinoma (NPC) associated with Epstein-Barr virus (EBV) chronic infection is a common head and neck malignancy in South China and Indonesia. Although radiation and chemotheraphy is the main theraphy, it requires repeated and invasive biopsy for pathological evaluation. Therefore, a marker is required for screening including the level of anti early antigen imunoglobin a serology level. Method: Pre-pots test, longitudinal cohort design. The PTV of 18 samples were examined using CT scan, while their serum EBV anti EA IgA level were examined using pre and post three series-cisplatin-paclitaxel chemotherapy ELISA. Results: Although there was no significant changes in the level of anti EA IgA, however we found a decrease in the mean of pre-chemotherapy anti EA IgA level from 136.49 U/ml to 124.61 U/ml. There was significant changes in the VTP in pre and post-chemotherapy (p<0.05). The mean of VTP in pre-chemotherapy was 66.26 cm3 (SD-38.61 cm3), while in post-chemotherapy was 31.64 cm3 (SD-27.5 cm3). The delta mean of changes in anti EA IgA level was 11.8 U/ml and in VTP was 34.62 cm3. No correlation was found between the changes of anti EA IgA and the changes of VTP in post-chemotheraphy (p>0.05). However, decreases were found in the level of EBV EA IgA and PTV in pre and post NPC patients. Conclusion: There were decreases of serum EBV EA IgA level and PTV in pre and post-chemotherapy NPC patients.
Association of Diffusion Weighted Magnetic Resonance Imaging Profile and Apparent Diffusion Coefficient Value with Brain Tumor’s Histopathology Hartati Rusmi Tri Wilujeng1, Anggraini Dwi Sensusiati2, M. Yamin Sunaryo Suwandi3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3152

Abstract

Background: Accuracy of preoperative brain tumor’s histopathologic differentiation is very important to determine preoperative staging, intraoperative management and postoperative therapy. Diffusion weighted magnetic resonance imaging is an advanced technique developed as an important method for brain tumor assessment. Objectives: This study aimed to investigate correlation between diffusion weighted imaging (DWI) profile and apparent diffusion coefficient (ADC) value with brain tumor’s histopathology. Methods: This study examined 86 subjects with brain tumors using magnetic resonance imaging and histopathology examination at Dr. Soetomo Teaching Hospital and evaluated DWI profile and ADC maps. The spherical ROI on ADC maps was placed on the solid part of the tumor to measure ADC value. Spearman’s correlation test was conducted to determine correlation between DWI profile and ADC values with histopathological grading and types of brain tumor. Results: There was a significant correlation between DWI profile and ADC values (p = 0.000), as well as DWI and ADC values with histopathological grading and types of brain tumor (p = 0.000). There was an inverse corelation between ADC value and histopathological grading. The higher the ADC value, the lower the brain tumor grade, while lower ADC value resulted in high tumor grade. The average ADC value of grade-1 meningiomas was 1.061±0.257 x 10-3 mm2/sec, pilocytic astrocytoma was 1.301±0.107 x 10-3 mm2/ sec, glioblastoma multiforme was 0.831±0.080 x 10-3 mm2/sec, and medulloblastomas was 0.600±0.078 x 10-3 mm2/sec. Conclusion: Evaluation on DWI profile and ADC value could provide additional information on conventional magnetic resonance imaging examination to determine histopathological grading and types of both intra and extra-axial brain tumors.
The Performance of Elastographic Diagnostic of Breast Tumor in Dr. Soetomo Teaching Hospital Surabaya Shinta Rosalina1 , Nifa Koesmarsono Wahid1 , Anggraini Dwi Sensusiati2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10754

Abstract

Background: Elastography in breast cancer cases has not become a routine examination that is conducted in the radiodiagnostic unit in Dr. Soetomo Teaching Hospital Surabaya. These last few years, elastography has been an addition examination modality which is promising to assess breast lesions that are detected byan ultrasound. Objective: The aim of the present study is to observe the performance of elastography in breast tumor cases. Method: This cross-sectional study was conducted in Dr. Soetomo Teaching Hospital Surabaya. The elastography is applied in 65 females (the average age is 49,1 years old) and it was found 66 lesions with a definitive diagnosis (34 benign tumors, 32 malignant tumors) which was proved through a fine-needle aspiration biopsy. The grayscale result is classified into benign and malignant categorizations with examining five descriptors including shape, margin, orientation, echo pattern, and posterior features. Results: The elastography score showed that the sensitivity is 87,5 %, the specificity is 94,1 %, and the accuracy is 90,9 % The stain ratio showed 93,8 %, 94,1 %, 90,9 % in sequence. On the other hand, the grayscale result showed 96,9 %, 91,2 %, and 95,5 %. The combination of elastography and grayscale showed a better performancewith the 97,1% of sensitivity, 94,1 % of specificity, and 93,8 % of accuracy. There was a significant correlation between the lesion size and the quality of elastography result (P = .034) while there was no correlation with the lesion depth (P = .624). Conslusion: The combination of elastography and grayscale have a better diagnostic performance in distinguishing benign breast tumor with malignant breast tumor.
DEMENTIA IN DR. SOETOMO GENERAL HOSPITAL SURABAYA: A SYNTHETIC REVIEW OF ITS CHARACTERISTICS Imami, Nabilah Hasna; Haryono, Yudha; Sensusiati, Anggraini Dwi; Hamdan, Muhammad; Hidayati, Hanik Badriyah
MNJ (Malang Neurology Journal) Vol. 7 No. 1 (2021): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2021.007.01.3

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Background: Dementia is a clinical syndrome characterized by progressive loss of cognitive function in elderly people interferes  the ability to function independently. The number of elderly patients increased so fast in worldwide. The prevalence of dementia rapidly increases due to increasing of population. Aging demographic transition is proceeding rapidly especially in China, India, and Latin America, where dementia is rapidly becoming the major public health problem. Demographic data of elderly patients of dementia in Indonesia is still a little. Dementia’s research data in Indonesia were only obtained  from Bali and Yogyakarta, while data from Surabaya were not obtained. Our research data is taken from Dr. General Hospital Soetomo Surabaya, East Java, Indonesia. This study is important for dementia epidemiological data and baseline data for further treatment of dementia patients in Surabaya.Objective: The purpose of this study to determine the characteristics profile of elderly patients  with dementia in Dr. Soetomo General Hospital Surabaya, East Java, Indonesia.Methods: Sampling was done with purposive sampling by observing the medical records of patients in the period of January 2017 to December 2017 based on inclusion and exclusion criterias that have been set. The data was taken from the patient's medical record which had been written and examined by neurologists from the neurology department in the neurobehaviour sub-department of Dr. Soetomo Surabaya.Results: The majority of dementia patients are men (51,7%); the age group which is most at risk for dementia is between age of  75-79 years; most of the patients are jobless; more than half of patients are high school graduates; and Vascular Dementia (VaD) is the type of dementia that  most people suferredConclusion: This characteristic’s data of dementia can be used for providing information about dementia to make public health care provides a better facillities and treatment for elderly patients to prevent dementia burden.
Epidemiology of Intra-Cerebral Hemorrhage in Young Adult Patients Melisa Melisa; Asra Al Fauzi; Anggraini Dwi Sensusiati
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 11 No. 2 (2020): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V11I22020.65-68

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Introduction: This study aimed to define the CT scan imaging of young adult intracerebral hemorrhage (ICH) patients in Dr. Soetomo General Hospital, Surabaya.Methods: This was an observational descriptive study. The data were collected retrospectively with medical records of 18 to 45 years old ICH patients who were treated in Dr. Soetomo General Hospital, Surabaya between 2014 and 2017. The collected data were then presented into tables.Results: 207 patients were identified in this study. The locations of the ICH were basal ganglia (45.89%), lobar (41.55%), thalamus (10.63%), brainstem (8.7%), cerebellum (4.83%), and others (3.86%). The volume of ICH varied from less than 30 cc (66.67%), 30 to 59 cc (27.54%), and more than 60 cc (5.8%).  Conclusion: The CT scan imaging of young adults ICH mainly had hematoma volume less than 30 cc and was mostly located in basal ganglia area then followed by lobar area. 
Phytoconstituent Analysis and Antibacterial Potential of Epicarp Extracts from Mature Fruits of Persea americana Mill Cyuzuzo Callixte; Dusabimana Jean Damascene; Anwar Ma&#039;aruf; Yoes Prijatna Dachlan; Anggraini Dwi Sensusiati; Ndayisaba Daniel; Eka Nora Vitaloka Aprilia Putri Winthoko
Molecular and Cellular Biomedical Sciences Vol 4, No 2 (2020)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1192.824 KB) | DOI: 10.21705/mcbs.v4i2.133

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Background: World Health Organization (WHO) has reported the antimicrobial resistance as one among the ten threats to global health in 2019. The development of plant-derived antibiotics is currently considered as a modern medicine’s greatest success. Persea americana is a plant with high medicinal profile which allow its different parts to be used for therapeutic purposes. This study is aimed to determine the antibacterial potential of ethanol and chloroform extracts from epicarp of mature fruits of P. americana Mill against human pathogens.Materials and Methods: The epicarps of avocado were dried in oven and ground into powder using porcelain mortar and pestle. The powdered plant materials were extracted with both 96% ethanol and chloroform. Extracts were qualitatively screened to examine their bioactive contents and agar well diffusion method was used to analyze the antibacterial activity of extracts against both Gram-positive and Gram-negative bacteria.Results: Both solvents showed the ability to dissolve the secondary metabolites from avocado epicarps. Phytochemical screening disclosed the presence of alkaloids, proteins, terpenoids, tannins, flavonoids, steroids and phenolic compounds in ethanolic extracts and absence of flavonoids and tannins in chloroform extracts. The extracts showed the inhibition zones ranging from 14±4.5 mm to 26±2.1 mm while streptomycin demonstrated high inhibition zones ranging from 20±3.1 mm to 30 mm. The minimum inhibitory concentration (MIC) values of extracts ranges from 0.3125 mg/mL to 20 mg/mL while the MIC values for streptomycin vary from 0.25 mg/mL to 1.25 mg/mL.Conclusion: The ethanol and chloroform extracts proved to be potentially effective as natural alternative preventives to fight against various disease-causing bacteria.Keywords: antibacterial activity, ethanol extract, chloroform extract, Persea americana, Rwanda
Pengetahuan, Gangguan Psikologis, dan Burnout Dokter Umum di Era Pandemi Covid-19 Alfian Nur Rosyid; Arina Dery Puspitasari; Tamara Nur Budiarti; Izzatul Fitriyah; Anggraini Dwi Sensusiati; Muhammad Amin
Jurnal Pengabdian Pada Masyarakat Vol 6 No 3 (2021)
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/002.202163.838

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KNOWLEDGE, PSYCHOLOGICAL DISORDERS, AND BURNOUT OF GENERAL PRACTITIONERS IN THE COVID-19 PANDEMIC ERA. High demand in work during the Covid-19 pandemic will cause psychological problems for general practitioners. These psychological disorders can cause burnout. The incidence of burnout is exacerbated by the lack of knowledge of general practitioners about the current condition. This study aims to determine the level of knowledge, psychological disorders, and burnout of general practitioners during the Covid-19 pandemic. The research design using quasi-experimental with one group pre posttest design without a control group. The population in this study was all participants that join the online seminar. Samples taken were 111 respondents with the total sampling technique. The data collection technique was done by using a questionnaire. The data obtained were analyzed using the Wilcoxon test and Kendall's tau-c test. The difference test before and after being given the seminar material shows a p-value of 0.001. The statistical analysis of the relationship between knowledge and burnout shows a p-value of 0.048. The statistical analysis of the relationship between stress and burnout shows a p-value of 0.026. The statistical analysis of the relationship between anxiety and burnout shows a p-value of 0.001. The statistical analysis of the relationship between depression and burnout showed a p-value of 0.002. There are differences in the knowledge of respondents before and after being given the seminar material. There is an association between knowledge with burnout, stress with burnout, anxiety with burnout, and depression with burnout.
Pemberdayaan Pasien dan Keluarga Pasien dalam Pencegahan Amputasi Penderita Diabetes di Kecamatan Mulyorejo Kota Surabaya, Jawa Timur Anggraini Dwi Sensusiati; Budi Suprapti; Marcha Debby Saraswati
Jurnal Pengabdian Pada Masyarakat Vol 6 No 4 (2021)
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/002.202164.849

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EMPOWERMENT OF PATIENTS AND PATIENT FAMILIES IN PREVENTION OF AMPUTATION OF DIABETES IN MULYOREJO DISTRICT, SURABAYA CITY, EAST JAVA PROVINCE. The purpose of implementing this community service program is to empower the community, especially patients and families of diabetes patients, to be able to take steps to prevent disability in diabetes due to amputation. The number of people with diabetes who have to undergo amputation is often influenced by the poor knowledge of diabetes, the low adherence to taking medication, and the poor knowledge and ability of patients and their families in performing wound care for diabetics. In addition, the lack of understanding of diabetes drugs causes the patient to experience side effects that can lead to withdrawal or the patient to experience side effects of hypoglycemia which can put the patient in critical condition. The solution to this problem is to empower diabetes patients and their families. They were given education about diabetes, the importance of taking the medication regularly according to doctor's recommendations, and wound care. In addition, they will be trained on how to do proper wound care for diabetes patients. A medication control post-program will be implemented to ensure that patients will take their medication according to the prescribed guidelines. It is hoped that with this program, the community will understand more about diabetes and its complications to avoiding the disabilities due to amputation by diabetics and patients can avoid unwanted side effects.
Komorbiditas Pasien Demensia di RSUD Dr. Soetomo Periode Januari–Desember 2017 Nabilah Hasna Imami; Yudha Haryono; Anggraini Dwi Sensusiati; Muhammad Hamdan; Hanik Badriyah Hidayati
AKSONA Vol. 1 No. 1 (2021): JANUARY 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.436 KB) | DOI: 10.20473/aksona.v1i1.95

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Pendahuluan: Demensia merupakan proses hilangnya fungsi kognitif seperti berpikir, mengingat, dan bernalar sehingga penderita demensia terganggu dalam melakukan kehidupan dan aktivitas sehari-hari pada seseorang. WHO menyebutkan bahwa jumlah pasien demensia di dunia terus meningkat. Pada tahun 2015, pasien demensia diprediksi mencapai 47,47 juta pasien dan dapat mencapai 75,63 juta pada 2030. Semakin meningkat usia lansia, faktor komorbiditas yang menyerang lansia juga semakin meningkat. Faktor komorbiditas dapat berupa penyakit kronik seperti stroke, hipertensi, DM, juga penyakit jantung. Tujuan: Untuk mengetahui prevalensi komorbiditas pada pasien lansia demensia di RSUD Dr. Soetomo Surabaya. Metode: Data diambil dari rekam medis pasien pada periode Januari hingga Desember 2017 di RSUD Dr. Soetomo Surabaya berdasarkan kriteria inklusi dan eksklusi yang telah ditetapkan. Hasil: Faktor komorbiditas yang paling banyak terjadi pada pasien demensia adalah stroke (57,3%), diikuti oleh hipertensi (50,6%), DM (30,3%), penyakit Parkinson (24,7%), dan penyakit Jantung (19,1%). Kesimpulan: Stroke merupakan komorbiditas paling banyak terjadi pada pasien dengan demensia. Hipertensi berada di tempat kedua paling banyak diderita lansia demensia. Pengendalian komorbiditas pada lansia sangat penting untuk dilaksanakan untuk mengendalikan risiko terjadinya penurunan fungsi kognitif.