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A Huge Vaginal Prolapse of Uterine Leiomyoma Complicated with Cervical Inversion: A Case Report Dewi, Ratih Frastika; Farida, Leny Silviana
Asian Journal of Health Research Vol. 2 No. 3 (2023): Volume 2 No 3 (December) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i3.129

Abstract

Introduction: Uterine fibroids are non-malignant neoplasms originating from the smooth muscle cells of the uterus, and they represent the most prevalent tumor seen within the female reproductive system. The primary established approach to manage this condition is surgical interventions, specifically myomectomy, hysterectomy, or hysteroscopic removal of small subserous nodules. Occasionally, submucous fibroids may protrude through the cervical os, thereby enabling the feasibility of performing a vaginal hysterectomy. Case Presentation: The clinical presentation of a 44-year-old multiparous woman who arrived with symptoms of vaginal bleeding and a sizable mass protruding through the vaginal opening. The patient underwent an emergency vaginal extraction to remove the mass measuring 24 cm in the emergency room and a scheduled for elective surgery. During the procedure, uterine inversion was found with a muscle bundle around the corpus uteri and a fourth-grade perineal tear. This patient was also planned for a total abdominal hysterectomy and bilateral-salphyngo-oophorectomy procedure, along with Haultain's procedure and perineal repair. The patient exhibited favorable surgical outcomes. Conclusion: Hysterectomy is the preferred therapy for prolapsed pedunculated submucous myoma. It has been seen that even exceptionally big nascent myomas can be effectively removed using vaginal means.
Antioxidant Agent to Improve Endometriosis Related Pain (Dysmenorrhea, Dyspareunia, Pelvic Pain): A Systematic Review and Meta-Analysis Daud, Vanessa Pradna Adyana; Dyarma, Kadiota Rasika; Farida, Leny Silviana
Asian Journal of Health Research Vol. 3 No. 1 (2024): Volume 3 No 1 (April) 2024
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v3i1.142

Abstract

Introduction: Endometriosis is a chronic condition characterized by the presence of endometrial-like tissue outside the uterus, which causes estrogen-induced inflammation. Pelvic severe pain, dysmenorrhea, and dyspareunia are known as the most common symptoms in endometriosis patients. Antioxidants can help alleviate endometriosis-related pain. However, the mechanism is not fully understood. A study is needed to elucidate the inherent potential of an antioxidant in women with endometriosis. Material and Methods: The literature search was conducted in two databases. The outcome of interest is to measure mean changes based on pain severity using the VAS score in endometriosis-related pain, including dysmenorrhea, pelvic pain, and dyspareunia. Some of the antioxidant agents formed in this study are vitamin D, vitamin C, vitamin E, livergol (silymarin), garlic tablets, resveratrol, and melatonin compared to placebo. Meta-analysis was done using RevMan 5.4 using mean change from baseline data with their 95% confidence intervals (CI) provided. Results: Twelve studies meeting the inclusion criteria were considered relevant for assessing the potencies of antioxidants in endometriosis patients (n=695). The antioxidant group had significantly better pelvic pain improvement (MD: -2.21, 95%CI: -3.40 to -1.03, p=0.0003), reduction in dyspareunia symptoms (MD: -1.47, 95% CI: -2.68 to -0.27, p=0.02) as well as improvement in dysmenorrhea with a mean difference -1.92 (95% CI: -3.41 to -0.43, p=0.01) than the placebo group. Antioxidants showed excellent potential to be an alternative treatment in managing endometriosis-related pain, particularly pelvic pain, dyspareunia, and dysmenorrhea. Conclusion: The efficacy of antioxidant agents can be a potential treatment to alleviate pain associated with endometriosis, such as pelvic pain, dysmenorrhea, and dyspareunia.
Exploring The Effect of Testosterone Hormonal Therapy on Sexual Problems in Postmenopausal Women: A Comprehensive Systematic Review on Clinical Trials Amri, Zidan Dzulyadain; Putri, Annisa Reanimasi Asmoro; Amanda, Nasyabila Anryandi; Torrences, Theodorica; Shadiq, Raihan; Farida, Leny Silviana
Asian Journal of Health Research Vol. 4 No. 2 (2025): Volume 4 No 2 (August) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i2.234

Abstract

Introduction: Sexual dysfunction is a common concern among postmenopausal women. Testosterone therapy has been proposed as a treatment option, yet evidence remains inconsistent.    Material and Methods: We searched PubMed, ScienceDirect, and EBSCOhost (January 2010–December 2024). Randomized controlled trials (RCTs) assessing testosterone versus placebo or control in postmenopausal women were included. Data extraction and synthesis were performed independently by two reviewers. Risk of bias was assessed using the Cochrane RoB 2 tool. RevMan 5.4 was used for meta-analysis.    Results: Seven articles were considered relevant for assessing the effect of testosterone or androgen therapy on sexual function and desire of postmenopausal women (n = 711). The testosterone group showed significant improvement in sexual activity or desire (OD: 3.18, 95% CI: 2.53 - 3.98, p< 0.00001). This result shows that testosterone therapy has the potential to improve sexual activity and desire in postmenopausal women.    Conclusion: Testosterone therapy may improve sexual function in postmenopausal women, but heterogeneity and limited long-term safety data warrant caution. Further high-quality RCTs are needed.