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All Journal Indonesian Journal of Urology Jurnal Prima Medika Sains
Hartanto, Richard
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Health Professions Medicine & Pharmacology Nursing Public Health

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SURVIVAL IN PATIENTS WITH HISTOLOGIC VARIANTS OF UROTHELIAL TYPE BLADDER CANCER Hartanto, Richard; Pramod, Sawkar Vijay
Indonesian Journal of Urology Vol 31 No 3 (2024)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v31i3.885

Abstract

Objective: This study aims to determine the life expectancy of patients with histologic variants in urothelial type bladder cancer and the highest or lowest mortality rate in Hasan Sadikin Academic Medical Centre. Material & Methods: A cross-sectional study with total sampling. The samples in this study were patients with histologic variants of urothelial cell carcinoma bladder who received treatment at Hasan Sadikin Academic Medical Centre during the period of 2011 to 2022. Results: A total of 470 patients with a diagnosis of urothelial bladder cancer, 62 patients (13.19%) with histologic variants of urothelial bladder cancer treated with radical cystectomy or TURBT + intravesical chemotherapy at Hasan Sadikin Academic Medical Centre. The highest survival rate was in patients diagnosed with giant cell (66.7%) followed by small cell (50%) and glandular differentiation (40.0%). The 5-yearr survival rate of patients treated with radical cystectomy alone had a higher survival rate of 75.3% followed by radical cystectomy and adjuvant therapy, which was 75.2%. Conclusion: Histologic variants of bladder carcinoma that have the highest mortality rate are tropoblastic differentiation, nested type, micropappilary, and sarcomatoid with the lowest survival rate of 0%. Also, histologic variant of bladder carcinoma that has the lowest mortality rate is giant cell with a survival rate of 66.7%. Keywords: Bladder carcinoma, chemotherapy, trophoblastic differentiation.
EFEK PENAMBAHAN EKSTRAK DAUN MANGGA ARUMANIS (MANGIFERA INDICA L.) PADA ANTIBIOTIK KLINDAMISIN DALAM MENGHAMBAT PERTUMBUHAN BAKTERI STAPHYLOCOCCUS AUREUS Hartanto, Richard; Khang, Vo Tran Gia; Trinh, Tran Pham Thuc; Novelya, Novelya; Wijaya, Cindy Denhara
Jurnal Prima Medika Sains Vol. 2 No. 1 (2020): Juni
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v2i1.955

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Staphylococcus aureus termasuk bakteri yang cukup sering dijumpai pada mulut, terutama pada kasus abses periodontal di mana perawatannya memerlukan pemakaian antibiotik. Tingginya angka resisten bakteri Staphylococcus aureus terhadap antibiotik menyebabkan banyaknya dicari pengobatan alternatif menggunakan herbal. Melihat efek penambahan ekstrak daun mangga arumanis (Mangifera indica L.) pada antibiotik klindamisin dalam menghambat pertumbuhan bakteri Staphylococcus aureus. Jenis dari penelitian ini adalah eksperimental laboratorium secara in vitro dengan 25 sampel. Konsentrasi ekstrak daun mangga yang digunakan 25%, 50%, 75%, 100% dan kelompok kontrol. Ekstrak dibuat dengan teknik maserasi dan uji daya hambat dengan metode Kirbi bauer. Hasil dianalisis menggunakan statistik ANOVA, lalu dilanjutkan dengan Post Hoc LSD. Hasil penelitian ini menunjukkan bahwa penambahan ekstrak 50%, 75%, 100% meningkatkan daya hambat terhadap Staphylococcus aureus (p=0,000) dibandingkan kelompok kontrol. Semakin tinggi konsentrasi yang digunakan, maka semakin besar zona hambat yang terbentuk. Sedangkan penambahan ekstrak 25% tidak meningkatkan daya hambat (p=0,618) bila dibandingkan dengan kelompok kontrol. Penambahan ekstrak daun mangga arumanis dengan klindamisin dapat meningkatkan aktivitas antibakteri terhadap Staphylococcus aureus.
Co-Authors Khang, Vo Tran Gia Novelya, Novelya Sawkar Vijay Pramod Trinh, Tran Pham Thuc Wijaya, Cindy Denhara