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EFEK PENAMBAHAN EKSTRAK DAUN MANGGA ARUMANIS (MANGIFERA INDICA L.) PADA ANTIBIOTIK KLINDAMISIN DALAM MENGHAMBAT PERTUMBUHAN BAKTERI STAPHYLOCOCCUS AUREUS Hartanto, Richard; Khang, Vo Tran Gia; Trinh, Tran Pham Thuc; Novelya, Novelya; Wijaya, Cindy Denhara
Jurnal Prima Medika Sains Vol. 2 No. 1 (2020): Juni
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v2i1.955

Staphylococcus aureus termasuk bakteri yang cukup sering dijumpai pada mulut, terutama pada kasus abses periodontal di mana perawatannya memerlukan pemakaian antibiotik. Tingginya angka resisten bakteri Staphylococcus aureus terhadap antibiotik menyebabkan banyaknya dicari pengobatan alternatif menggunakan herbal. Melihat efek penambahan ekstrak daun mangga arumanis (Mangifera indica L.) pada antibiotik klindamisin dalam menghambat pertumbuhan bakteri Staphylococcus aureus. Jenis dari penelitian ini adalah eksperimental laboratorium secara in vitro dengan 25 sampel. Konsentrasi ekstrak daun mangga yang digunakan 25%, 50%, 75%, 100% dan kelompok kontrol. Ekstrak dibuat dengan teknik maserasi dan uji daya hambat dengan metode Kirbi bauer. Hasil dianalisis menggunakan statistik ANOVA, lalu dilanjutkan dengan Post Hoc LSD. Hasil penelitian ini menunjukkan bahwa penambahan ekstrak 50%, 75%, 100% meningkatkan daya hambat terhadap Staphylococcus aureus (p=0,000) dibandingkan kelompok kontrol. Semakin tinggi konsentrasi yang digunakan, maka semakin besar zona hambat yang terbentuk. Sedangkan penambahan ekstrak 25% tidak meningkatkan daya hambat (p=0,618) bila dibandingkan dengan kelompok kontrol. Penambahan ekstrak daun mangga arumanis dengan klindamisin dapat meningkatkan aktivitas antibakteri terhadap Staphylococcus aureus.

Pomegranate Extracts as a Natural Denture Cleanser: A Promising Alternative to Sodium Bicarbonate for Inhibiting Candida albicans Wijaya, Cindy Denhara; Sumitro; Annisa Rizqi Ramadhani Sitio; Fitriah Khairani Harahap
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1253

Background: Denture stomatitis, caused primarily by Candida albicans overgrowth, is a common oral health issue among denture wearers. Maintaining denture hygiene is crucial for prevention. This study investigated the efficacy of red pomegranate (Punica granatum L.) peel and fruit extracts as natural denture cleansers compared to sodium bicarbonate, a standard denture cleansing agent. Methods: Heat-cured acrylic resin plates were fabricated and contaminated with C. albicans. Samples were divided into four groups and soaked for 8 hours in: 75% pomegranate peel extract, 75% pomegranate fruit extract, 5% sodium bicarbonate solution (positive control), and aquadest (negative control). C. albicans colony counts were performed using the spread plate technique and colony counter. Data were analyzed using Kruskal-Wallis and Mann-Whitney tests. Results: Both pomegranate peel and fruit extracts significantly reduced C. albicans growth compared to the negative control (p<0.05). The peel extract showed comparable efficacy to sodium bicarbonate (p>0.05), while the fruit extract demonstrated slightly lower but still substantial antifungal activity. Conclusion: Red pomegranate peel and fruit extracts hold promise as natural denture cleansers for inhibiting C. albicans and potentially preventing denture stomatitis. Further research is warranted to evaluate their long-term effects on denture materials and clinical efficacy.

A comparison of the effect of soaking in 75% pomegranate peel and pulp extract versus sodium hypochlorite on the surface roughness of heat-cured acrylic resin denture bases Watri, Desi; Wijaya, Cindy Denhara; Harahap, Fitriah Khairani; Pakpahan, Sadesma Uli; Oktavia, Yuli; Sitio, Annisa Rizqi Ramadhani
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.6792

Heat-cured acrylic resin is the most common material used for denture bases; however, it has limitations such as susceptibility to fluid absorption and abrasion, which can increase surface roughness. This roughness has the potential to become a site for the colonisation of microorganisms such as Candida albicans. Sodium hypochlorite is frequently used as a denture disinfectant, but its corrosive properties can exacerbate surface roughness. Therefore, alternative natural materials such as pomegranate (both peel and pulp) extracts have become a focus of research. Aim: This study aimed to determine the comparative effects of immersion in 75% pomegranate peel extract and 75% pomegranate pulp extract versus sodium hypochlorite on the surface roughness of heat-cured acrylic resin. Method: This study employed a pre- and post-test control group experimental laboratory design, with three treatment groups of nine samples each. Acrylic resin samples were immersed for 7 days and 14.5 hours in the treatment solutions, and their surface roughness was measured using a surface roughness tester before and after immersion. Data analysis was performed using the Shapiro-Wilk test, One-Way ANOVA, and Post Hoc Tukey test. Results: This study found no significant difference between the treatment groups regarding the surface roughness of heat-cured acrylic resin (p = 0.718). However, only the sodium hypochlorite group showed a significant change in surface roughness before and after immersion (p = 0.003), whereas the pomegranate peel and pulp extract groups did not show significant changes (p = 0.099 and p = 0.065, respectively). Conclusion: 75% pomegranate peel and pulp extracts did not cause significant changes to the surface roughness of heat-cured acrylic resin and may represent safer natural alternatives to sodium hypochlorite as denture soaking solutions.

Antibacterial Effectiveness of Rambutan Peel Extract (Nephelium lappaceum L.) in Inhibiting the Growth of Enterococcus Faecalis Bacteria Wijaya, Cindy Denhara; Rajindervir Singh; Mellisa Sim
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 4 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i4.487

Backgrounds. This research is a study that seeks to explore the potential of rambutan extract in inhibiting the growth of Enterococcus faecalis bacteria, where this bacterium is one of the bacteria that is often found in the oral cavity and often causes infections and dental and oral problems. Methods. This research is an experimental study in vitro. This study aims to determine the diameter of the inhibition zone of rambutan peel extract on Enterococcus faecalis. Rambutan peel extracts were tested at levels of 5%, 7.5% and 10% with NaOCl (Sodium Hypochlorite) 2.5% control, where each test group was tested on 6 culture plates of Enterococcus faecalis bacteria. Results. The 10% rambutan peel extract group had the highest inhibition zone diameter of 12.4 ± 1.21 mm. Rambutan peel extract 5% - 10% showed a higher inhibition zone diameter than the control NaOCl 2.5%. The results of the effectiveness test of the diameter of the inhibition zone between the test groups. Rambutan peel extracts 5%, 7.5% and 10% showed different levels of inhibition zone diameter compared to 2.5% NaOCl. Rambutan peel extract 5%, 7.5%, and 10% had a higher diameter of the inhibition zone than the 2.5% NaOCl control. Conclusion. Rambutan peel extract 5%, 7.5% and 10% were more effective in inhibiting the growth of Enterococcus faecalis than control NaOCl.

Antibacterial Effectiveness of Rambutan Peel Extract (Nephelium lappaceum L.) in Inhibiting the Growth of Enterococcus Faecalis Bacteria Wijaya, Cindy Denhara; Rajindervir Singh; Mellisa Sim
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 4 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i4.487

Backgrounds. This research is a study that seeks to explore the potential of rambutan extract in inhibiting the growth of Enterococcus faecalis bacteria, where this bacterium is one of the bacteria that is often found in the oral cavity and often causes infections and dental and oral problems. Methods. This research is an experimental study in vitro. This study aims to determine the diameter of the inhibition zone of rambutan peel extract on Enterococcus faecalis. Rambutan peel extracts were tested at levels of 5%, 7.5% and 10% with NaOCl (Sodium Hypochlorite) 2.5% control, where each test group was tested on 6 culture plates of Enterococcus faecalis bacteria. Results. The 10% rambutan peel extract group had the highest inhibition zone diameter of 12.4 ± 1.21 mm. Rambutan peel extract 5% - 10% showed a higher inhibition zone diameter than the control NaOCl 2.5%. The results of the effectiveness test of the diameter of the inhibition zone between the test groups. Rambutan peel extracts 5%, 7.5% and 10% showed different levels of inhibition zone diameter compared to 2.5% NaOCl. Rambutan peel extract 5%, 7.5%, and 10% had a higher diameter of the inhibition zone than the 2.5% NaOCl control. Conclusion. Rambutan peel extract 5%, 7.5% and 10% were more effective in inhibiting the growth of Enterococcus faecalis than control NaOCl.

A comparison of the effect of soaking in 75% pomegranate peel and pulp extract versus sodium hypochlorite on the surface roughness of heat-cured acrylic resin denture bases Watri, Desi; Wijaya, Cindy Denhara; Harahap, Fitriah Khairani; Pakpahan, Sadesma Uli; Oktavia, Yuli; Sitio, Annisa Rizqi Ramadhani
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.6792

Heat-cured acrylic resin is the most common material used for denture bases; however, it has limitations such as susceptibility to fluid absorption and abrasion, which can increase surface roughness. This roughness has the potential to become a site for the colonisation of microorganisms such as Candida albicans. Sodium hypochlorite is frequently used as a denture disinfectant, but its corrosive properties can exacerbate surface roughness. Therefore, alternative natural materials such as pomegranate (both peel and pulp) extracts have become a focus of research. Aim: This study aimed to determine the comparative effects of immersion in 75% pomegranate peel extract and 75% pomegranate pulp extract versus sodium hypochlorite on the surface roughness of heat-cured acrylic resin. Method: This study employed a pre- and post-test control group experimental laboratory design, with three treatment groups of nine samples each. Acrylic resin samples were immersed for 7 days and 14.5 hours in the treatment solutions, and their surface roughness was measured using a surface roughness tester before and after immersion. Data analysis was performed using the Shapiro-Wilk test, One-Way ANOVA, and Post Hoc Tukey test. Results: This study found no significant difference between the treatment groups regarding the surface roughness of heat-cured acrylic resin (p = 0.718). However, only the sodium hypochlorite group showed a significant change in surface roughness before and after immersion (p = 0.003), whereas the pomegranate peel and pulp extract groups did not show significant changes (p = 0.099 and p = 0.065, respectively). Conclusion: 75% pomegranate peel and pulp extracts did not cause significant changes to the surface roughness of heat-cured acrylic resin and may represent safer natural alternatives to sodium hypochlorite as denture soaking solutions.

Pengaruh Hydrogel Acemannan dengan Konsentrasi 25%, 50%, 75% terhadap Jumlah Neutrofil pada Tikus Wistar Periodontitis yang Diinduksi Aloksan Susanto, Chandra; Wijaya, Cindy Denhara; Turnip, Gebriela Lam Ulina Putri
Jurnal Penelitian Pendidikan IPA Vol 10 No 4 (2024): April
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i4.7054

Neutrophils occur in periodontitis, an infection of the periodontal tissue that may increase the risk of diabetes. Because of its excellent physicochemical properties and biological capabilities, hydrogel is a promising biomaterial for treating periodontal disease. This study consisted of four groups of Acemannan hydrogel 25%, 50%, 75%, and the Federer formula was used to determine the sample size and six replicate experiments were performed for each group to form a positive control group. Considering the investigation's conclusions, in the acemannan hydrogel administration group, the average ± SD levels of neutrophils in samples on day 3 were 25%, 50%, and 75%, and the positive control group was 3.08 ± 0.736. 2.46 ± 0.459; 1.54 ± 0.510; 1.17 ± 0.258. This value decreased to 1.83 ± 0.258 by day 5 were 1.29 ± 0.459; 0.50±0.447; 0.21 ± 0.292. As a result of the Kruskal-Wallis statistical test, there was a significant difference in the average number of neutrophils after administering 25%, 50%, and 75% Acemannan hydrogel and the positive control group to rats with alloxan-induced Wistar periodontitis on the third and fifth days. The study's findings suggest that 75% of acemannan hydrogel is the most effective concentration for reducing neutrophils

Pomegranate Extracts as a Natural Denture Cleanser: A Promising Alternative to Sodium Bicarbonate for Inhibiting Candida albicans Wijaya, Cindy Denhara; Sumitro; Annisa Rizqi Ramadhani Sitio; Fitriah Khairani Harahap
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1253

Background: Denture stomatitis, caused primarily by Candida albicans overgrowth, is a common oral health issue among denture wearers. Maintaining denture hygiene is crucial for prevention. This study investigated the efficacy of red pomegranate (Punica granatum L.) peel and fruit extracts as natural denture cleansers compared to sodium bicarbonate, a standard denture cleansing agent. Methods: Heat-cured acrylic resin plates were fabricated and contaminated with C. albicans. Samples were divided into four groups and soaked for 8 hours in: 75% pomegranate peel extract, 75% pomegranate fruit extract, 5% sodium bicarbonate solution (positive control), and aquadest (negative control). C. albicans colony counts were performed using the spread plate technique and colony counter. Data were analyzed using Kruskal-Wallis and Mann-Whitney tests. Results: Both pomegranate peel and fruit extracts significantly reduced C. albicans growth compared to the negative control (p<0.05). The peel extract showed comparable efficacy to sodium bicarbonate (p>0.05), while the fruit extract demonstrated slightly lower but still substantial antifungal activity. Conclusion: Red pomegranate peel and fruit extracts hold promise as natural denture cleansers for inhibiting C. albicans and potentially preventing denture stomatitis. Further research is warranted to evaluate their long-term effects on denture materials and clinical efficacy.

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