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Flavonoid Pada Buah Jengkol (Pithecellobium Lobatum Benth) Sebagai Terapi Alternatif Diabetes Melitus Tipe 2 Kurniawan, Denny Andika
Wellness And Healthy Magazine Vol 2, No 2 (2020): Agustus
Publisher : Universitas Aisyah Pringsewu (UAP) Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/well.022.82000141

Abstract

Obat antidiabetes oral banyak memberikan efek samping yang tidak diinginkan, salah satunya obat golongan sulfonilurea yang memiliki efek samping hipoglikemik dan toksisitas hematologik,  obat biguanid memiliki efek samping yaitu gangguan pencernaan, asidosis laktat dan menurunnya absorpsi vitamin B12 sedangkan obat akarbose memiliki efek samping  flatulens, diare dan nyeri abdomen. Diabetes Mellitus  adalah salah satu penyakit tidak menular dengan pravelensi yang tinggi di dunia, Indonesia menempati urutan keempat jumlah penderita diabetes terbesar di dunia setelah India, Cina dan Amerika Serikat. Oleh karena itu, banyaknya efek samping yang terdapat dalam obat – obatan Diabetes Melitus serta fakta bahwa Diabetes Melitus memiliki prevalensi yang tinggi khususnya di Indonesia, para ahli mengembangkan sistem pengobatan tradisional untuk terapi Diabetes mellitus yang relatif aman. Salah satu terapi tradisional yang banyak digunakan oleh masyarakat di Indonesia adalah terapi herbal. Saat ini lebih dari 400 jenis tanaman telah digunakan sebagai pengobatan alternatif. Salah satu tanaman herbal yang berkhasiat sebagai antidiabetik tersebut adalah jengkol (Pithecellobium  jiringa). Jengkol dapat dimanfaatkan sebagai bahan obat-obatan dan diketahui secara tradisional dapat mencegah diabetes serta dapat menurunkan gula darah pada penderita diabetes mellitus. Kandungan senyawa kimia aktif pada biji, kulit batang, dan daun jengkol adalah alkaloid, steroid or triterpenoid, glikosida, saponin, flavonoid, dan tannin.Dari beberapa kandungan yang terdapat pada buah jengkol, Flavonoid adalah yang digunakan sebagai agen antidiabetes dengan cara menjadi agen protektif sel beta pankreas serta dapat meningkatkan sensitivitas insulin.  Abstract: Oral antidiabetic drugs many side effects that are not desired, one of the drugs known as sulfonylureas that have side effects hypoglycemic and toxicity hematologic, drug biguanide have side effects, namely indigestion, lactic acidosis and decreased absorption of vitamin B12, while the drug acarbose have side effects flatulence, diarrhea and abdominal pain. Diabetes Mellitus is one of the non-infect diseases with high prevalence in the world, Indonesia is the fourth-largest number of diabetics in the world after India, China and the United States. Therefore, the many side effects of the drug contained in Diabetes Mellitus, and the fact that Diabetes Mellitus has a high prevalence, especially in Indonesia, experts developed a system of traditional medicine for the treatment of diabetes mellitus is relatively safe. One of the traditional therapy that is widely used by people in Indonesia is herbal therapy. Currently, more than 400 species of plants have been used as an alternative treatment. One of the herbs that are useful as antidiabetic djengkol (Pithecellobium jiringa). Djengkol can be used as a medicine and known traditionally to prevent diabetes and can lower blood sugar in patients with diabetes mellitus. The content of the active chemical compounds in the seeds, bark, and leaves jengkol are alkaloids, steroids or triterpenoids, glycosides, saponins, flavonoids, and tannins. From some of the content contained in fruit jengkol, Flavonoids are used as antidiabetic agents to adopt a pancreatic beta cell protective agent and can improve insulin sensitivity.
Perbandingan Absolute Lymphocyte Count (ALC) Antara Pasien Terkonfirmasi Dengan Probable Covid 19 Di RSUD Pesawaran Kurniawan, Denny Andika; Utama, Winda Trijayanthi
Medula Vol 16 No 3 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i3.1763

Abstract

Coronavirus Disease 2019 (COVID-19) is a broad group of viruses known to cause diseases with a diverse clinical spectrum, ranging from mild symptoms to severe disorders in humans. These viruses are zoonotic, meaning they can be transmitted from animals to humans, posing a major challenge in infection control efforts. In addition, variations in immune responses in each individual cause the clinical picture of Covid-19 to vary greatly, including changes in laboratory parameters such as absolute lymphocyte count (ALC). This study was conducted to analyze the differences in ALC values in patients with a confirmed diagnosis of Covid-19 compared to patients categorized as probable Covid-19 at the Pesawaran Regional General Hospital. The study design used an observational analytical method with a cross-sectional approach. Data processing and analysis were performed using an independent t-test to assess the difference in means between the two groups. The total sample consisted of 45 patients, namely 20 patients with confirmed Covid-19 and 25 patients with probable Covid-19. The results showed that the mean ALC value in the confirmed group was 1,241.5/µL, while in the probable group it reached 1,812.59/µL. These findings indicate a statistically significant difference between the mean ALC of the two groups, with a p-value of 0.0001. This difference also supports the findings of previous studies that lymphopenia is more commonly found in patients with verified Covid-19 infection. Thus, this study confirms that Covid-19 confirmation status is associated with changes in ALC, which can be a supporting clinical parameter in the evaluation and monitoring of patient conditions.