Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal Journal of Indonesian Tourism and Development Studies Bioinformatics and Biomedical Research Journal
Alfaruqi, Nuri Thobibatus Shofia
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Education Engineering Environmental Science Social Sciences

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
The In Silico Analysis and Identification of Possible Inhibitor of H5N1 Virus: Compounds Analysis and Identification of Possible Neuraminidase Inhibitors Syafrudin, Syafrudin; Septiadi, Luhur; Alfaruqi, Nuri Thobibatus Shofia; Wahyudi, Didik; Kharisma, Viol Dhea
Bioinformatics and Biomedical Research Journal Vol. 1 No. 2 (2018): Volume 1 Issue 2
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Fingerroot (Boesenbergia pandurata (Roxb.)) belongs to the family Zingiberaceae (Ginger). B. pandurata has pharmacological benefits such as neuroprotective, chemoprotective, anti-inflammatory, anti-angiogenic, antioxidant, an inhibitor of protease enzyme NS2B/NS3 dengue virus, Japanese encephalitis virus and swine flu virus (H1N1). This study aims to determine the most effective compounds from B. pandurata as neuraminidase inhibitors of H5N1 virus. The amino acid sequence for neuraminidase of avian influenza A virus subtype H5N1 of A/China/GD02/2006 was retrieved from protein sequence database at NCBI. Then, modeled by Swiss Model. Analyse of molecular docking was performed using PyRx and the interactions between neuraminidase inhibitors of H5N1 and B. pandurata active compound was analyzed by PyMol software and LigPlot+ software. From the 30 active compounds which have been docked, 4-hydroxypanduratin A, rubranine, boesenbergin B, boesenbergin A, 5,7-dimethoxyflavone, and tectochrysin had an equal or smaller free binding energy than control compound. 4-hydroxypanduratin A proved to be the most potent active compound as a neuraminidase inhibitor (NA 1) because it has the most negative binding energy and the same amino acid binding residue with the control compound. Therefore, 4-hydroxypanduratin A is predicted to be used as inhibitors of neuraminidase in the H5N1 virus.
The Invasive Plants Species along the Hiking Track of Mount Panderman Nature Tourism, Batu, East Java Septiadi, Luhur; Wahyudi, Didik; Rachman, Rhesma Sylvia; Syafrudin, Syafrudin; Alfaruqi, Nuri Thobibatus Shofia
Journal of Indonesian Tourism and Development Studies Vol. 6 No. 1 (2018)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jitode.2018.006.01.08

Abstract

Indonesia has the highest biodiversity that places ecotourism as a sustainable development sector. The negative impact of ecotourism is the vulnerability to invasive plant species growth. They invade the habitat of the native plants and potentially alter the biodiversity balance. This invasive plant introduction is predicted caused by tourist and hiker visits. Therefore, the inventory of invasive plant species is urgently needed. The field survey was conducted on March 11-12, 2017 to inventory invasive plant species along the Panderman Mountain hiking track that common travelers explored and then identified. Species of Pinus Caribaea, Chromolaena odorata, Lantana camara, Leucaena leucocephala, Pennisetum purpureum are categorized invasive plants. Four species of plants otherwise potentially invasive include Calliandra calothrysus, Ageratum conyzoides, Bidens pilosa, and Acacia deccurens. The widespread access to protected environmental destinations leads to the spread of highly invasive species. The impact of invasive species depends on factors such as reproduction rate, vegetative phase, adaptability of seeds that can withstand adverse conditions and in particular human vectors as a way of spreading them.Keywords: Batu, Ecotourism, Hiking track, Invasive plants, Panderman Mountain.
Co-Authors Didik Wahyudi Kharisma, Viol Dhea Rachman, Rhesma Sylvia Septiadi, Luhur Syafrudin Syafrudin