Pathak, Vinay
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Synthesis and characterization of 5-aryl-1,3,4-oxadiazole-2(3h)thione derivatives Pathak, Shailesh; Sharma, Sharad; Pathak, Vinay; Prasad, Mahesh
Journal of Applied Pharmaceutical Research Vol. 8 No. 4 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.4.50.61

Abstract

1,3,4-oxadiazoles represent a class of heterocyclic five membered compounds it contain two nitrogen and one oxygen of great importance in Pharmaceutical chemistry. This nucleus show four isomeric forms 1,2,4-oxadiazole,1,3,4-oxadiazole, 1,2,5-oxadiazole, and 1,2,3-oxadiazole. This nucleus has various biological activity such as antioxidant, antimicrobial, antifungal, antitumor, antidepressant, anticancer, analgesic etc.  have been reported. A series of 1,3,4-oxadiazoles-2(3H)thione derivative has been synthesized in four steps and the derivative were characterized by FTIR spectral analysis. This article explain the different biological activities associated with 1,3,4-oxadiazole five membered ring are useful for researchers across the world working on this nucleus.