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All Journal Majalah Kedokteran Andalas Indonesian Journal of Cancer
Hartono, Henky
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Hubungan antara tumor-infiltrating lymphocytes dengan parameter klinikopatologi pada kanker kolorektal Trianto, Heru Fajar; Pratiwi, Sari Eka; Ilmiawan, Muhammad In'am; Hartono, Henky; Ftrianingrum, Iit; Lestari, Desriani
Majalah Kedokteran Andalas Vol. 46 No. 4 (2023): Online Oktober
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i6.p949-958.2023

Abstract

Latar Belakang: Kanker kolorektal termasuk dalam keganasan terbanyak di dunia. Berbagai faktor turut mempengaruhi prognosis dari kanker salah satunya sistem imun. Sistem imun di sekitar tumor memiliki pengaruh terhadap progesivitas sel kanker. Salah satu sistem imun yang dapat diamati adalah Tumor-infiltrating lymphocytes (TIL). Tujuan: Penelitian ini bertujuan untuk membuktikan adanya hubungan antara TIL dengan berbagai parameter klinikopatologi pada kanker kolorektal. Metode : Penelitian ini menggunakan desain potong lintang. Subjek penelitian berupa 38 sampel blok parafin dan slide hematoksilin-eosin (HE) serta data klinikopatologi yang berasal dari sediaan operasi kanker kolorektal pada Laboratorium Patologi Anatomi RSUD Dr. Soedarso periode Januari – Desember 2020. Penilaian jumlah TIL dibagi menjadi tiga kelompok yaitu ringan (0-10%), sedang (11-59%), dan berat (60-100%). Hasil: Hasil penelitian menunjukkan bahwa jumlah TIL terbanyak adalah TIL berat yaitu sebanyak 16 kasus (42,1%). Hasil uji korelasi Spearman menunjukkan hubungan antara jumlah TIL dengan derajat diferensiasi, stadium Dukes dan stadium p TNM dengan nilai p<0,005. Tidak terdapat hubungan antara jumlah TIL dengan ukuran tumor, status metastasis kelenjar getah bening, status metastasis jauh, dan lokasi tumor. Kesimpulan: Terdapat hubungan antara jumlah TIL dengan derajat keganasan, stadium Dukes dan stadium pTNM yang merupakan faktor-faktor prognosis pada kanker kolorektal.
Differentiation of Microvessel Density Based on The Breast Cancer Patient Characteristics Including Age, Stage, Tumor Size, and Lymph Node Metastasis Salsabila, Tasya; Pratiwi, Sari Eka; Trianto, Heru Fajar; Ilmiawan, Muhammad In'am; Lestari, Desriani; Fitrianingrum, Iit; Hartono, Henky
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1041

Abstract

Background: Breast cancer is the most common malignant tumor in the world and Indonesia. One well-known prognostic marker is microvessel density (MVD), the numerical value of angiogenesis. In recent years, it has been recognized that tumor growth depends on angiogenesis. Therefore, this study aimed to determine the differentiation of MVD based on the breast cancer patients' characteristics including age, stage, tumor size, and lymph node metastasis in the Anatomical Pathology Laboratory of Soedarso Hospital. Methods: This research was an observational study with a cross-sectional approach. The study was conducted by observing the slides of Hematoxylin-Eosin (HE) in breast cancer patients. Samples were taken using the total sampling technique. The samples were observed by two observers. 51 tissue preparations met the inclusions and exclusions criteria. MVD cut-off points are taken by calculating the median. Research analysis was using the Kruskal-Wallis test in SPSS version 24. Results: All samples of this study were women and had invasive ductal carcinoma. Breast cancer tends to occur in patients aged 48-53 years, has stage III, lymph node metastasis (N2). The patients have a low MVD rate but have a large tumor size (T4). Kruskal Wallis test showed that there was a differentiation of MVD based on age (p = 0.029). While, there was no differentiation of MVD based on stage (p=0.974), tumor size (0.069), and lymph node metastasis (0.571). Conclusions: There was a differentiation of MVD based on the age of breast cancer patients in the Anatomical Pathology Laboratory at Soedarso Hospital.
Co-Authors Ftrianingrum, Iit Ilmiawan, Muhammad In'am Lestari, Desriani Salsabila, Tasya Sari Eka Pratiwi Trianto, Heru Fajar