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All Journal Jurnal Mahasiswa PSPD FK Universitas Tanjungpura Jurnal Kesehatan Andalas Jurnal Pendidikan Informatika dan Sains Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Kedokteran dan Kesehatan Majalah Kedokteran Andalas Muhammadiyah Medical Journal Indonesian Journal of Cancer Indonesian Journal of Biomedicine and Clinical Sciences Biomedika
Ilmiawan, Muhammad In'am
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Gambaran Tingkat Pengetahuan Wanita Usia Subur tentang Imunisasi Tetanus Toksoid di Desa Sungai Rengas ., Hardianto; Irsan, Abror; Ilmiawan, Muhammad In'am
Jurnal Mahasiswa PSPD FK Universitas Tanjungpura Vol 4, No 1 (2018): Jurnal Cerebellum
Publisher : Jurnal Mahasiswa PSPD FK Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar belakang. Imunisasi Tetanus toksoid (TT) adalah pemberian imunisasi tetanus pada wanita usia subur (WUS) atau sedang mengandung yang merupakan pencegahan terhadap tetanus neonatorum yang paling mudah dan efektif. Dengan pemberian imunisasi tetanus lengkap, maka perlindungan terhadap infeksi tetanus bisa mencapai lebih dari 90%. Dikatakan lengkap apabila WUS sudah mendapatkan imunisasi tetanus sebanyak 5 kali yang akan memberikan perlindungan terhadap tetanus selama 25 tahun. Metode. Penelitian ini adalah penelitian deskriptif dengan desain cross sectional. Data diambil dari 97 responden Pemilihan sampel dilakukan melalui metode pengambilan sampel berdasarkan peluang (probability sampling), yaitu dengan cara stratified random sampling. Hasil. Berdasarkan hasil penelitian yang telah dilakukan, didapatkan sebagian besar responden memiliki pengetahuan yang baik tentang imunisasi TT. Kesimpulan. Sebagian besar responden memiliki pengetahuan yang baik tentang imunisasi TT.Kata kunci: Imunisasi TT, tetanus neonatorum, wanita usia suburBackground. Tetanus toxoid Immunization is tetanus immunization for women of childbearing age or for pregnant women that Is a precaution against tetanus neonatorum that can be most easily and effective. By the provision of complete tetanus immunization So protection against infection tetanus Can reach more than 90%. It will be said complete when women of childbearing age are already getting tetanus immunization as many as 5 times that will provide Protection against tetanus for 25 years. Method. This research is a descriptive research with the cross sectional design . Based on opportunities ( probability sampling ) , a stratified random sampling Data were taken from 97 respondent. The Sample selection is done through a method of sampling Based on opportunities ( probability sampling ) with a stratified random sampling. Result. Based on the results of the research which has been done , most of the respondent have a good knowledge about tetanus toxoid. Conclusion. Most of the respondent Have a good knowledge about tetanus toxoid.Keywords: tetanus toxoid immunization , neonatorum tetanus, childbearing age womans
Uji Efek Protektif Kombinasi Minyak Jintan Hitam (Nigella sativa) Komersial dan Madu pada Sel Leydig Tikus Jantan Galur Wistar yang Diberi Pajanan Cisplatin Putranda, Muhammad Afia Akbar; Ilmiawan, Muhammad In'am; Handini, Mitra
Jurnal Kedokteran dan Kesehatan Vol 19, No 1 (2023): JURNAL KEDOKTERAN DAN KESEHATAN
Publisher : Faculty of Public Health, Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/jkk.19.1.83-90

Abstract

Cisplatin merupakan obat antikanker yang memiliki sifat toksik bagi sel normal seperti sel Leydig. Kombinasi minyak jintan hitam dan madu sebagai antioksidan diketahui memberikan efek protektif pada sel akibat paparan cisplatin. Penelitian ini bertujuan untuk mengetahui efek protektif kombinasi minyak jintan dan madu pada gambaran histologi sel Leydig yang diberi pajanan cisplatin. Desain penelitian ini adalah randomized post-test only control group menggunakan 30 ekor tikus yang dibagi dalam 10 kelompok: kontrol (K), MJH I 1 ml/kgBB (P1), MJH II 2 ml/kgBB(P2), M I 3,7 ml/kgBB(P3), M II 7,4 ml/kgBB(P4), kelompok kombinasi MJH I dan M I (P5), MJH I dan M II (P6), MJH II dan M I (P7), MJH II dan M II (P8), dan kelompok cisplatin (C). Minyak jintan hitam dan madu diberikan secara oral selama 21 hari. Cisplatin 8 mg/kgBB diberikan secara intraperitoneal di hari ke-18 pada semua kelompok kecuali kontrol. Sel Leydig diamati menggunakan mikroskop cahaya pada 10 lapang pandang besar/kecil kemudian dihitung persentase kerusakannya. Hasilnya menunjukkan minyak jintan hitam dan madu dalam bentuk tunggal dan kombinasi mengurangi kerusakan sel Leydig. Kelompok kombinasi minyak jintan hitam dan madu memberikan efek protektif yang sinergis terhadap sel Leydig tikus yang diberi pajanan cisplatin.
Chlorogenic Acid Protects Cell Death in the Cerebellum through Anti-Apoptotic Protein Bcl2 in Transient Global Ischemia Cases Hermawati, Ery; Handini, Mitra; Ilmiawan, Muhammad In'am; Mahyarudin, Mahyarudin
Molecular and Cellular Biomedical Sciences Vol 8, No 1 (2024)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v8i1.411

Abstract

Background: Cerebellum is one of the vital components of the brain that will be affected by ischemia-reperfusion (IR) injury. IR injury will increase free radicals, which in turn can trigger apoptosis and cell death. Therefore, this study was conducted to examine the effect of chlorogenic acid administration on apoptosis and the number of cells in the cerebellum of rats with global ischemic transients.Materials and methods: Wistar rats were divided into five groups: sham-operated (C1), IR (C2), IR + 15 mg/kgBW chlorogenic acid (T1), IR + 30 mg/kgBW chlorogenic acid (T2), and IR + 60 mg/kgBW chlorogenic acid (T3). C2, T1, T2, and T3 groups received bilateral common carotid occlusion (BCCO) surgery to induce IR injury. Thirty minutes after BCCO surgery, T1, T2, and T3 rats were administered chlorogenic acid in various doses intraperitoneally. RNA extraction and real-time polymerase chain reaction (PCR) measurements were then performed on NeuN, Bcl2, Bax, caspase 3, as well as on GAPDH as housekeeping genes.Results: There were significant differences in NeuN expressions between groups, with the highest expression shown in C1 followed by T3. Bcl2 expressions were also significantly different between groups, and rats in C1 and T3 showed to be significantly higher compared to C2, while T1 was significantly lower than C1. However, Bax and caspase 3 expressions showed no significant differences.Conclusion: Chlorogenic acid in 60 mg/kgBW dose increases NeuN expression and Bcl2 mRNA expression after transient global ischemia. These increases might correlate with the heightened level of protection against apoptosis in the cerebellum, hence showing its potential in protecting neuron cells.Keywords: transient global ischemia, chlorogenic acid, cerebellum, apoptosis
Chemopreventive effect of dayak onion [Eleutherine bulbosa, Mill. (Urb)] against 7,12-dimethylbenz [α] anthracene (DMBA)-induced breast cancer in rats: study on cancer antigen 15-3 (CA 15-3) Efrem, Deo Gratias; Ilmiawan, Muhammad In'am; Pratiwi, Sari Eka
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 3 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i3.12245

Abstract

Dayak onion [Eleutherine bulbosa, Mill. (Urb)] is herbal plant believed to have anticancer effects. It contains triterpenoids, flavonoids, anthraquinones, and naphthoquinones which have antioxidants and anticancer activities. This study aimed to investigate the effect of ethanolic extract of dayak onion bulb (EEDO) on serum cancer antigen 15-3 (CA 15-3) levels in rats induced with 7,12-dimethylbenz [a] anthracene (DMBA). Thirty female Sprague Dawley rats were randomly divided into six groups, namely Normal Group, Positive Control Group (tamoxifen), Negative Control Group (dimethyl sulfoxide/DMSO) 5%), Treatment Group I (EEDO 180 mg/kgBW), Treatment Group II (EEDO 360 mg/kgBW) and Treatment Group III (EEDO 720 mg/kgBW). All groups, except the normal group, were induced with DMBA 20 mg/kg body weight. Serum CA 15-3 levels were determined using enzyme-linked immunosorbent assay (ELISA) method. The results showed significantly lower (p< 0.05) CA 15-3 levels in the Treatment Groups compared to the Negative Control Group. The most significant reduction in serum CA 15-3 level was observed in the Treatment Group I receiving EEDO at a dose of 180 mg/kgBW. In conclusion, the EEDO possesses a chemopreventive effect on DMBA-induced breast cancer in rats.
The Role of Tumor-Associated Macrophage Density to Tumor Size and Lymph Node Metastases of Invasive Ductal Carcinoma Patients at Dr. Soedarso General Hospital Pontianak Nugraha, Muhammad Fikri; Pratiwi, Sari Eka; Ilmiawan, Muhammad In'am; Trianto, Heru Fajar; Fitrianingrum, Iit; Hartono, Hengky
Indonesian Journal of Cancer Vol 18, No 4 (2024): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i4.1161

Abstract

Background: Invasive ductal carcinoma is the most common form of breast cancer worldwide and has a high mortality rate. The main component of the innate immune system in the tumor environment is the tumor-associated macrophage (TAM). Certain types of TAM are known to affect tumor size and lymph node metastasis which makes the cancer prognosis worse. Currently, TAM identification is generally identified using immunohistochemical staining techniques that require high costs and special expertise. An easy and inexpensive TAM identification technique is needed in determining breast cancer prognostic factors. This study focused on TAM density and its role in tumor size and lymph node metastases of invasive ductal carcinoma patients.Methods: This research is an observational analytic study using a cross-sectional approach. This study was conducted by observing the Hematoxylin-Eosin (HE) preparation of invasive ductal carcinoma patients. This study used 55 medical record data and histopathology laboratory reports of invasive ductal carcinoma patients at Dr. Soedarso General Hospital Pathological Anatomy Laboratory. TAM density cut-off is measured by calculating the median data of TAM density. Research analysis was performed using Spearman’s rho correlation test in SPSS version 24.Results: The cut-off value for determining TAM density obtained from observations based on the average value was 29. The highest number of tumor size groups was T4, and the highest number of lymph node metastases was N2. TAM density was significantly not correlated to tumor size (p = 0.285, p 0.05) and lymph node metastases (p = 0.479, p 0.05) Conclusions: This study found no significant correlation between TAM density, assessed through a cost-effective method using HE staining, and tumor size or lymph node metastasis in invasive ductal carcinoma patients.
Protective Effect of Combination Commercial Black Seed Oil (Nigella sativa) and Honey Against Cisplatin-Induced Hepatotoxicity in Rats Siddiq, Andri Muhrim; Ilmiawan, Muhammad In'am; Handini, Mitra
Muhammadiyah Medical Journal Vol 1, No 2 (2020): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (568.669 KB) | DOI: 10.24853/mmj.1.2.43-48

Abstract

Background: The chemotherapeutic use of cisplatin (CP) is restricted because of its hepatotoxicity induced by oxidative stress. Malondialdehyde (MDA) is a secondary product of lipid peroxidation as a biomarker of oxidative stress. Individual administration of black seed oil (BSO) or honey (H) demonstrated hepatoprotective effect in rats. Interaction of both substances when administrated as combination can be evaluated using combination index (CI) to quantitatively depict synergism (CI1), additive (CI=1) and antagonism effect (CI1). Objective: to know the combination effect of BSO and honey on rat liver tissue given CP exposure. Methods: This study used 30 rats were divided into 10 groups. Normal group (N); Negative control group (NC); P1-P4 groups were administerated BSO (1 and 2 mL/kg) and honey (3.7 and 7.4 mL/kg); P5-P8 groups were combination of BSO and H. P1-P8 groups were given BSO and honey orally for 21 days. On the 18th day, NC and P1-P8 groups were given CP 8 mg/kg intraperitoneally, while the N group was given NaCl 0.9% 1 mL/kg intraperitoneally. Result: Malondialdehyde (MDA) levels were found to be lower in P1-P8 groups compared to negative control group and P6 and P7 groups have levels equivalent to MDA levels of normal control group (p 0.05). Conclusion: Combination of BSO and honey provides a protective effect on cisplatin-induced rat liver tissue damage indicated by reduced MDA levels, but all combination group showed antagonism effect.
Overview Of Gluten-Free Casein-Free Diet Application in Children With Autism Spectrum Disorder Sandy A.K., Risky; Pratiwi, Sari Eka; Ilmiawan, Muhammad In'am
Biomedika Vol 16, No 1 (2024): Biomedika Februari 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v16i1.3854

Abstract

Background: The theory that gluteomorphin and casomorphin can act as opiate-like peptides has an effect like opiates by binding to specific receptors in the central nervous system, which triggers the implementation of a casein-free gluten-free diet (GFCF). The binding of gluten and casein derivates in these specific receptors leads to increased activity of the endogenous opioid system associated with symptoms of autism spectrum disorder. Objectives: To describe the application of a casein-free gluten-free diet in children with autism spectrum disorder (ASD). Materials and Methods: We conducted this research with cross-sectional design quantitative research using total sampling (38 respondents, all female, mother) in July-August 2021 with a food frequency questionnaire (FFQ). Results: The result revealed that the average age of ASD children is 10.47 years, weight 35.87 kilograms, height 141.45 centimeters, and mostly boys (68%). Most parents (86.8%) didn’t adopt a GFCF diet. FFQ score mostly amounting to >150 (57.9%). Conclusion: ASD children in SLB Autis Kalbar are given foods with gluten and casein with diverse variations enough that children have an FFQ score >150, and their parents didn’t implement GFCF diet.
Hubungan Albuminuria dan Laju Filtrasi Glomerulus pada Pasien Diabetes Melitus Tipe 2 yang Tidak Terkontrol Parinding, Vinny Vania; Ilmiawan, Muhammad In'am; Fitrianingrum, Iit; Trianto, Heru Fajar; Mardhia, Mardhia
Jurnal Kesehatan Andalas Vol. 11 No. 2 (2022): Online July 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i2.1994

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. Patients with diabetes mellitus require optimal glycemic control. Poorly controlled diabetes mellitus is at risk for complications, such as diabetic nephropathy. Diabetic nephropathy is characterized by albuminuria and can lead to decreased Glomerular Filtration Rate (GFR). Objectives: To determined the relationship between albuminuria and GFR in a patient with poorly controlled type 2 diabetes mellitus. Methods: This research was conducted at the Pontianak Branch of Prodia Health Clinic Laboratory in March 2021, using secondary data of laboratory examination results from DM patients in the 2020 period. This research was observational analytics with a cross-sectional approach. The number of samples that comply with the research criteria was 273 people. Bivariate analysis using Spearman’s correlation test. Results: Spearman's correlation test results showed significance (p=0.001) and correlation coefficient (r=0.209). Conclusion: Albuminuria and GFR in a patient with poorly controlled type 2 diabetes mellitus are significantly and positively correlated.Keywords:  albuminuria, poorly controlled type 2 diabetes mellitus, glomerular filtration rate
Efek pemberian bawang hitam siung tunggal (Allium sativum) terhadap memori jangka pendek tikus Wistar Hasanah, Uswatun; Hermawati, Ery; Handini, Mitra; Mahyarudin, Mahyarudin; Alex, Alex; Ilmiawan, Muhammad In'am
Jurnal Pendidikan Informatika dan Sains Vol. 14 No. 1 (2025): Jurnal Pendidikan Informatika dan Sains
Publisher : IKIP PGRI Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31571/saintek.v14i1.8482

Abstract

Bawang hitam siung tunggal memiliki kandungan antioksidan dan memiliki efek sebagai pelindung terutama pada korteks prefrontal, yang juga berperan dalam fungsi memori. Selain efek antioksidan, bawang hitam siung tunggal memiliki efek anti inflamasi serta modulasi neurotransmitter seperti asetilkolin pada otak yang berhubungan pada pasien dengan gangguan memori. Penelitian ini bertujuan untuk mengetahui efek bawang hitam siung tunggal terhadap memori jangka pendek pada tikus wistar. Penelitian ini merupakan penelitian laboratorium eksperimental dengan dengan desain post-test only control group design. Pada penelitian ini menggunakan 24 ekor tikus yang dibagi kedalam 4 kelompok yaitu kontrol, BG1, BG2, dan BG3 dengan diberi ekstrak etanol bawang hitam siung tunggal sebanyak 2,5 gr, 5 gr, dan 10 gr yang dilarutkan dengan NaCl 0,9% peroral secara berurutan selama 10 hari. Pada hari ke 15 setelah perlakuan terakhir kemudian dilakukan pengujian y maze untuk menentukan menentukan persentase alternasi. Tikus wistar dalam 4 kelompok memiliki hasil persentase yang tidak jauh berbeda pada setiap kelompok yaitu pada kontrol (67.408% ± 9.28%), BG1 (75.72 ± 10.75), BG2 (67.00% ± 9.89%), dan BG3 (73.73% ± 12.69%). Analisis data dengan Uji Krusskal Wallis menunjukkan bahwa tidak terdapat pengaruh ekstrak bawang hitam siung tunggal terhadap memori jangka pendek tikus wistar ( P = 0,492). Kesimpulan pada penelitian ini adalah ekstrak bawang hitam siung tunggal (Allium sativum Linn) tidak memberikan pengaruh terhadap memori jangka pendek pada tikus wistar.
Hubungan Antara Durasi Penggunaan Gadget Terhadap Perkembangan Dasar Anak Usia Prasekolah di Taman Kanak-Kanak (TK) Kota Pontianak Aswada, Dias Arivia; Andriani, Rini; Ilmiawan, Muhammad In'am
Majalah Kedokteran Andalas Vol. 47 No. 2 (2024): MKA April 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i2.p181-191.2024

Abstract

Latar Belakang : Sebesar 1-3% anak di bawah usia 5 tahun mengalami keterlambatan perkembangan dasar, dimana penggunaan gadget yang berlebihan merupakan salah satu penyebabnya.1 Tujuan: Mengetahui hubungan antara durasi penggunaan gadget terhadap perkembangan dasar anak usia prasekolah di Taman Kanak-kanak (TK) Kota Pontianak. Metodologi: Penelitian ini bersifat analitik dengan desain potong lintang pada 96 siswa di TK Kota Pontianak. Hasil penelitian diuji dengan uji statistik chi square menggunakan SPSS 23.0. Hasil: Analisis univariat menunjukkan gadget milik orang tua sebesar 84,5% dan pengenalan gadget dilakukan oleh orang tua berjumlah 80,2% serta usia anak paling muda mengenal gadget adalah 8 bulan. Terdapat 15 orang (15,6%) mengalami penyimpangan, sebagian besar pada aspek bicara bahasa. Analisis bivariat antara durasi penggunaan gadget terhadap perkembangan dasar yaitu p=0,376. Kesimpulan: Terdapat anak yang mengalami penyimpangan perkembangan namun tidak ditemukan hubungan bermakna antara durasi penggunaan gadget terhadap perkembangan dasar anak usia prasekolah di Kota Pontianak.
Co-Authors ., Hardianto Abror Irsan Alex Alex Aswada, Dias Arivia Efrem, Deo Gratias Ery Hermawati Fathoni, Izzuddin Ftrianingrum, Iit Handini, Mitra Hartono, Henky Hengky Hartono Laili, Kharima Lestari, Desriani Mahyarudin, Mahyarudin Mardhia, Mardhia Nugraha, Muhammad Fikri Parinding, Vinny Vania Putranda, Muhammad Afia Akbar Rini Andriani Ronaldo, Andriano Salsabila, Tasya Sandy A.K., Risky Sari Eka Pratiwi Siddiq, Andri Muhrim Trianto, Heru Fajar Uswatun Hasanah