Article Per Year (5 Year)
p-Index From 2020 - 2025
0.23
P-Index
This Author published in this journals
All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN
Liauw, Josephine Johan
Unknown Affiliation
Health Professions Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
The Antifungal Effect of Kesum Leaf (Polygonum minus Huds) in Ethanol Extract on Microsporum gypseum Liauw, Josephine Johan; Rizki, Syarifah Nurulyanti; Natalia, Diana; Mahyarudin, Mahyarudin
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 12, No 1 (2021): June 2021
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1258.247 KB) | DOI: 10.30659/sainsmed.v12i1.4448

Abstract

Introduction: Dermatophytosis or tinea is a disease found in the keratinized tissues caused by dermatophytes. The prolonged use of antifungal drugs has adverse effects on humans. Kesum leaves (Polygonum minus Huds) contains the secondary metabolite properties which can act as anti-fungi. Objective: This study aimed to determine the antifungal activity of ethanol extract of kesum leaves in inhibiting the Microsporum gypseum.Methods: Phytochemical analysis was performed using a test tube method and thin layer chromatography. The antifungal activity test used a disc diffusion method with the extract concentrations of 5%, 10%, 20%, 40%, and 80%. Kesum leaves macerated using ethanol 96% solvent. Itraconazole 8µl/disk and DMSO4 were respectively used as positive and negative control. Results: Phytochemical analysis on the ethanol extract of kesum leaves showed the secondary metabolite groups of flavonoids, alkaloids, terpenoids, phenolics, and saponins. Ethanol extract of kesum leaves did not form an inhibitory zone on the growth of Microsporum gypseum. Meanwhile in the positive control, in the form of itraconazole 8 µl/disk, the inhibition zone was formed around the disc with a mean value of 37.5 mm.Conclusion: Ethanol extract of kesum leaves (Polygonum minus Huds) has no antifungal activity against the growth of Microsporum gypseum.
Co-Authors Asseggaf, Syarifah Nurul Yanti Rizki Syahab Diana Natalia Mahyarudin, Mahyarudin