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Panggabean, Ronaldo
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing

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The Hepatoprotective Effects of Basil Leaf (Ocimum sanctum L.) Extract on Paracetamol Induced Liver Damage in Male Rat Panggabean, Ronaldo; Nofita; Ade Maria Ulfa
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.518

Abstract

Basil leaf have antioxidants such as flavonoids, so it is thought to have a hepatoprotective effect. This study aims to investigate the effect of basil leaf extract on SGOT and SGPT levels in male rats induced by paracetamol. Basil leaf extract was carried out by the percolation method using ethyl acetate solvent, Some 20 male sprague dawley rats were randomly divided into 5 groups. Basil leaf extract (400 mg/kgBB and 600 mg/kgBB) and sylimarin (100 mg/kgBB) were carried out every day for 28 days, paracetamol was induced 24 hours after giving the last day of basil leaf extract. The parameters measured were SGOT and SGPT level to assess the effect of basil leaf extract on liver damage caused by paracetamol. The results showed that basil leaf extract (400 mg/kgBB dan 600 mg/kgBB) showed that the activities of SGOT and SGPT levels were statistically significant (p<0,05) to negative control. Basil leaf extract shows the effect of hepatoprotector on liver induced by paracetamol, however the effect given was not able to equate with positive control.
Analisis Persediaan Obat dengan Menggunakan Metode Ven (Vital, Esensial, Non Esensial) dan Metode Eoq (Economic Order Quantity) dan Pengaruhnya Terhadap Ketersediaan Obat Panggabean, Ronaldo; Kosasih, Kosasih; Rulia, Rulia
Jurnal Ners Vol. 9 No. 3 (2025): JULI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i3.46603

Abstract

Penelitian ini bertujuan untuk mengetahui tentang analisis persediaan obat dengan menggunakan metode VEN (Vital, Esensial, Non Esensial) dan metode EOQ (Economic Order Quantity) dan pengaruhnya terhadap ketersediaan obat di Instalasi Farmasi Rumah Sakit Pertamina Bintang Amin. Metode penelitian yang digunakan dalam penelitian ini adalah metode deskriptif dan verifikatif dengan pendekatan kuantitatif dan menggunakan analisis regresi linier berganda. Teknik pengambilan sampel menggunakan nonprobabilitas atau sampel jenuh yaitu metode penentuan sampel dengan memilih seluruh anggota populasi sebagai responden. Responden berjumlah 7 orang sebagai petugas terkait persediaan obat di Instalasi Farmasi Rumah Sakit Pertamina Bintang Amin. Hasil analisis deskriptif berdasarkan skor rata-rata kuesioner pada metode VEN (Vital, Esensial, Non esensial) (X1) sebesar 4,16. Skor rata-rata kuesioner pada metode EOQ (Economic Order Quantity) (X2) sebesar 4,11. Skor rata-rata kuesioner pada ketersediaan obat (Y) sebesar 3,97. Terbukti hasil penelitian menunjukan bahwa metode VEN dan metode EOQ secara simultan berpengaruh positif dan signifikan terhadap ketersediaan obat. Besarnya persentase sumbangan pengaruh variabel independen metode VEN dan metode EOQ terhadap variabel dependen ketersediaan obat sebesar 97,7%. Sedangkan sisanya sebesar 2,3% dipengaruhi atau dijelaskan oleh variabel lain yang tidak dilakukan dalam model penelitian ini.
Co-Authors Ade Maria Ulfa KOSASIH KOSASIH, KOSASIH Nofita Rulia, Rulia