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All Journal Medula JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Nisa Karima
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Agriculture, Biological Sciences & Forestry Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : medula

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Managemen Topikal Anti-Aging pada Kulit Winda Puspita Sari; Meligasari L.Gaya; Galih Irianto; Nisa Karima
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.263

Abstract

The Aging skin is a complex biological process involving endogenous or intrinsic factors (genetics, cellular communication, hormones, and mining processes) and exogenous or extrinsic factors (explanation of light, radiation, ionizing radiation, chemicals, and diverted) which are structural changes and cumulative physiological and progressive changes in each layer of the skin and changes in the appearance of the skin such as wrinkles and spots.These factors cause oxidative stress on the skin which triggers damage to cells and skin tissue. At present it is very popular to use anti-aging products. Anti-aging approach is based on the pathophysiology that occurs. So that care can be given to work optimally. Anti-aging can be done using cosmetic treatments, topical agents that contain anti-oxidants and cell regulators. In addition to topical treatments, it can be given systemically or invasively. In this review we will discuss topical anti-aging treatments.
Perbandingan, Monoterapi, Double Terapi, Triple Kombinasi Terapi Pada Pasien Glaukoma Primer Sudut Terbuka Di Rumah Sakit Mata Lampung Eye Center Syalsa Zaiva; Nisa Karima
Medula Vol 16 No 3 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i3.1764

Abstract

The eye is an essential sensory organ that delivers visual information to the brain. Glaucoma is a progressive optic neuropathy that can disrupt this process and lead to irreversible blindness. Primary open angle glaucoma is the most common type and is characterized by a gradual increase in intraocular pressure with minimal early symptoms. Glaucoma treatment is usually initiated with single drug therapy or monotherapy. If monotherapy is insufficient to control intraocular pressure, combination therapy using two or more medications is required, including double therapy and triple combination therapy. This study aimed to compare the effectiveness of monotherapy, double therapy, and triple combination therapy in reducing intraocular pressure in patients with primary open angle glaucoma at Lampung Eye Center Eye Hospital. An observational analytic method with a cross sectional design was used. Data on intraocular pressure and treatment regimens were obtained from medical records. Bivariate analysis was performed using the Kruskal Wallis test. The results showed that most subjects were male, with 23 patients or 53.5%, and the most common age group was 40 to 60 years, accounting for 41.9% of participants. Of the 43 patients included, 20.9% (9 patients) received monotherapy, 60.5% (26 patients) received double therapy, and 8 patients or 18.6% received triple combination therapy. Bivariate analysis demonstrated a statistically significant reduction in intraocular pressure in patients receiving triple combination therapy, with a p value less than 0.05. These findings indicate that triple combination therapy provides the most significant intraocular pressure reduction in patients with primary open angle glaucoma.
Co-Authors Alif Fernanda Putra Galih Irianto Meligasari L.Gaya Muhammad Yusran Nurdyana Nurdyana Rizki Hanriko Syalsa Zaiva Winda Puspita Sari Zalfa Salsabila Aprilia