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All Journal Jurnal ABDINUS : Jurnal Pengabdian Nusantara Journal of Health and Nutrition Research Journal Of Biology Education Research (JBER)
Suhendra, Meyla
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health

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Phytocemical Screening and Toxicity Test of Ethanolic Extracts Phanera semibifida (Roxb.) Benth. Stem and Leaves from West Sumatra Suhendra, Meyla; Fitmawati; Anisa, Nur; Kurnia, Hersan Bayu
Journal Of Biology Education Research (JBER) Vol. 5 No. 2 (2024): JBER (Journal Of Biology Education Research)
Publisher : Program Studi Pendidikan Biologi FKIP Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55215/jber.v5i2.15

Abstract

Indonesian people use plants as medicine because they are considered to have fewer side effects. Phanera semibifida (Roxb.) is a climbing plant that has been used by the community to make therapeutic drugs. Phanera semibifida, especially species in western Sumatra, lacks information on phytochemical composition and toxicity capabilities. So the purpose of this study was to determine the phytochemical content, toxicity (BSLT), and biological activity of Phanera semibifida growing in western Sumatra. The BSLT approach was used in this study to conduct phytochemical screening and toxicity studies on leaves and stems. Phytochemical results were negative for alkaloids and steroids but positive for flavonoids, tannins, saponins, and terpenoids. Based on the BSLT experiment, it can be concluded that both ethanol extracts are highly toxic and show anticancer properties
Pemanfaatan Wadah Plastik Bekas untuk Bertanam Sayuran dalam Ketahanan Pangan Keluarga Masa Pandemi Covid19 Di Desa Padang Luas Kecamatan Tambang Kabupaten Kampar, Riau Isda, Mayta Novaliza; Titrawani, Titrawani; Surjawati, Surjawati; Suhendra, Meyla; Fatonah, Siti
Jurnal ABDINUS : Jurnal Pengabdian Nusantara Vol 6 No 3 (2022): Volume 6 Nomor 3 Tahun 2022
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/ja.v6i3.16827

Abstract

Currently, the use of plastic containers is increasing which has an impact on landfilling because the material is difficult to decompose. One alternative effort to reduce plastic container waste is to use it as a vegetable growing medium. Vegetables that are grown can be consumed every day, which can increase the family's food, especially during the COVID-19 pandemic which has resulted in a weakening economy. Therefore, this training activity on the utilization of used plastic waste containers was carried out in Padang Luas Village, Tambang Sub District, District Kampar, Riau. This activity aims to provide knowledge, insight and stimulate creativity in processing plastic waste to the community in utilizing used plastic containers to grow vegetables. Methods of training activities include material presentation, demonstration of making plant pots from used plastic, and making plant pots with the community. The training activities have proceeded as planned. The results of the questionnaire after the training activities showed that most of the people gave a positive response and would apply the knowledge they gained from the training. Overall, participant answer really liked (54%) and liked (46%) the use of plant pots from used plastic containers. This training activity can be the beginning of the implementation of the use of used plastic waste to be more useful.
Anticancer Activity of Phanera semibifida Extract Evaluated by Brine Shrimp Lethality Test (BSLT) and Molecular Docking Studies Suhendra, Meyla; Juliandi, Berry; Darusman, Huda Shalahudin; Sadiah, Siti; Fitmawati, Fitmawati; Rianti, Puji
Journal of Health and Nutrition Research Vol. 5 No. 1 (2026)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v5i1.850

Abstract

Indonesian people use plants as medicine because they are considered to have fewer side effects. The Lingga island community used Phanera semibifida (Roxb.) traditionally to make therapeutic drugs. P. semibifida has the potential to be a medicinal plant. We extracted stems and leaves with three different solvents and tested their cytotoxic activity. The ethanolic stem extract showed the highest value of LC₅₀ in the moderate toxicity category. The ethanolic steam extract continued to be subjected to in silico analysis, using molecular docking. We selected four compounds for molecular docking studies against five cancer-related proteins. The proteins are Estrogen receptor α, CDK2, Human Cytochrome P450 CYP17A1, Cyclin A, and BCL-2. The result showed that Ellagic acid bound strongly to Estrogen receptor α, CDK2, CYP17A1, and Cyclin A protein. Cyanidanol showed the highest affinity to BCL-2. These results suggest that P. semibifida contains compounds that can target multiple cancer-related proteins. Our findings highlight its potential as a source of anticancer agents. We recommend isolating these compounds and testing their efficacy through in vitro and in vivo studies to confirm their therapeutic potential in future studies.
Co-Authors Berry Juliandi Fitmawati Fitmawati Huda Shalahudin Darusman Kurnia, Hersan Bayu Mayta Novaliza Isda Nur Anisa Puji Rianti Sadiah, Siti Siti Fatonah Surjawati, Surjawati Titrawani Titrawani, Titrawani