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All Journal Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Keperawatan Jurnal Ilmiah Kesehatan Sandi Husada
Sholehah, Laila
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Health Professions Medicine & Pharmacology Nursing Public Health Veterinary Other

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Antioxidant activity on the extract combination of Averrhoa bilimbi l. and Phaleria macrocarpa Laila Sholehah; Shanti Listyawati; Arief Nurudhin
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 10 ISSUE 1, 2022
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2022.10(1).15-21

Abstract

ABSTRAK Pendahuluan: Berbagai penyakit degenerative seperti DM erat kaitannya dengan stres oksidatif dan abnormalitas lipid akibat radikal bebas yang tidak terkendali. Salah satu penangkal radikal bebas yaitu antioksidan, Averrhoa bilimbi L. dan Phaleria macrocarpa merupakan tanaman yang memiliki banyak khasiat yang bermanfaat terutama senyawa antioksidannya.Tujuan: Penelitian ini bermaksud untuk melihat aktivitas antioksidan dari kombinasi ekstrak Averrhoa bilimbi L. dan Phaleria macrocarpa berdasarkan pada nilai IC50 sehingga dapat dilihat potensinya sebagai alternatif pengobatan DMT2.Metode: Ekstrak diolah menggunakan metode maserasi dengan etanol 96% kemudian dilakukan remaserasi sebanyak dua kali, lalu dikombinasikan dengan konsentrasi 50% Averrhoa bilimbi L dan 50% Phaleria macrocarpa. Pengujian aktivitas antioksidan dilakukan dengan metode DPPH berdasarkan perhitungan nilai IC50.Hasil: Hasil penelitian menunjukkan bahwa asam askorbat memiliki nilai IC50 sebesar 10,65 ppm, Averrhoa bilimbi L. memiliki nilai IC50 sebesar 8,29 ppm, Phaleria macrocarpa memiliki nilai IC50 sebesar 6,43 ppm, dan kombinasi ekstrak Averrhoa bilimbi L. dan Phaleria macrocarpa memiliki nilai IC50 sebesar 6,43 ppm. Nilai IC50 sebesar 5,26 ppm. Semakin kecil nilai IC50 maka semakin kuat aktivitas antioksidannya.Kesimpulan: Berdasarkan hasil tersebut dapat disimpulkan bahwa kombinasi ekstrak Averrhoa bilimbi L. dan Phaleria macrocarpa memiliki aktivitas antioksidan yang lebih tinggi dibandingkan dengan kedua ekstrak tunggal sehingga kombinasi tersebut berpotensi menjadi alternatif pengobatan DMT2.KATA KUNCI: Averrhoa bilimbi L.; Phaleria macrocarpa; DPPH; IC50 ABSTRACT Background: Various degenerative diseases such as DM are closely related to oxidative stress and lipid abnormalities due to uncontrolled free radicals. One of the free radical scavengers, namely antioxidants, Averrhoa bilimbi L. and Phaleria macrocarpa are plants that have many useful properties, especially their antioxidant compounds.Objectives: This study aims to examine the antioxidant activity of the combination of extracts of Averrhoa bilimbi L. and Phaleria macrocarpa based on the IC50 value so that it can be seen its potential as an alternative treatment for DMT2.Methods: The extract was processed using the maceration method with 96% ethanol then remaceration twice, then combined with a concentration of 50% Averrhoa bilimbi L and 50% Phaleria macrocarpa. Testing of antioxidant activity was carried out using the DPPH method based on the calculation of the IC50 value.Results: The results showed that ascorbic acid had an IC50 value of 10.65 ppm, Averrhoa bilimbi L. had an IC50 value of 8.29 ppm, Phaleria macrocarpa had an IC50 value of 6.43 ppm, and a combination of Averrhoa bilimbi L. and Phaleria macrocarpa extracts have an IC50 value of 5.26 ppm. The smaller the IC50 value, the stronger the antioxidant activity.Conclusion: Based on these results, it can be concluded that the combination of extracts of Averrhoa bilimbi L. and Phaleria macrocarpa has higher antioxidant activity than the two single extracts so the combination has the potential to be an alternative treatment for DMT2.KEYWORDS: Averrhoa bilimbi L.; Phaleria macrocarpa; DPPH; IC50
Phaleria Macrocarpa and Averrhoa Bilimbi L as Alternative Medicines in the Treatment of Patients with Diabetes Mellitus Type 2 Laila Sholehah; Shanti Listyawati; Arief Nurudhin
Jurnal Keperawatan Vol 14 No 2 (2022): Jurnal Keperawatan: Supp Juni 2022 "The 4th Udayana International Nursing Confer
Publisher : Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.342 KB)

Abstract

DM is a metabolic disease characterized by blood glucose levels that closely related to oxidative stress and lipid abnormalities. There are side effects of the drugs, such as nausea, dizziness, and so other alternatives are needed with natural ingredients and lower side effects. One of them are Phaleria macrocarpa and Averrhoa bilimbi. The compounds can reduce GDP,MDA and improve lipid profile in DMT2. The aim is to determine Phaleria macrocarpa and Averrhoa bilimbi as alternative treatments. The method is a systematic review of 34 journals. Based on the analysis, Phaleria macrocarpa and Averrhoa bilimbi were shown to reduce GDP,MDA and improve lipid profile. The decrease GDP from saponin can reduce glucose absorption in the intestine and inhibit the glucose transporter GLUT-1, while the decrease MDA is due to flavonoids which play a role in suppressing free radicals production, inhibiting the production of inflammatory mediators, and increasing endogenous antioxidants. Improvement of lipid profile from niacin can reduce blood cholesterol levels by inhibiting VLDL secretion mechanism. It was concluded that Phaleria macrocarpa and Averrhoa bilimbi could be used as alternative drugs for the treatment of DMT2 by lowering GDP, MDA and improving lipid profile.
Flavonoid Content Combination of Averrhoa bilimbi L and Phaleria macrocarpa Fruit Extract as Chemoprevention Agent against COVID-19 Sholehah, Laila; Listyawati, Shanti; Nurudhin, Arief
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No S1 (2022): Suplement 1
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1258.362 KB) | DOI: 10.30604/jika.v7iS1.1077

Abstract

The covid pandemic that has occurred for more than two years is still not over. Even in January 2022, with the new variant, Omicron, the number of COVID-19 cases has increased dramatically. According to statistics, on January 25 there were 3,559,000,464 new cases of COVID-19 and an average of 7 days as many as 3,397,073 cases. Therefore, it is important to take preventive measures to avoid the COVID-19 virus. One of them by eating foods high in antioxidants. Some fruits that are high in antioxidants are Averrhoa bilimbi L and Phaleria macrocarpa. Flavonoids are one of the types of antioxidants found in Averrhoa bilimbi L and Phaleria macrocarpa which function to inhibit the formation of Reactive Oxygen Species (ROS) by inhibiting enzymes in the formation of ROS and increasing the regulation and protection of antioxidants to prevent various negative impacts such as degenerative diseases and decreased immunity so that it can prevent exposure to the COVID-19 virus. The purpose of this study was to determine the levels of flavonoids in the combination of extracts of Averrhoa bilimbi L and Phaleria macrocarpa. The method used is the UV-VIS spectrophotometry method. The result of this research is that the flavonoid content of Averrhoa bilimbi L is 2.32 mg/g, the extract of Phaleria macrocarpa is 4.83 mg/g and the combination of the two is 4.77 mg/g. From these results, it can be said that the extract of Phaleria macrocarpa has the highest flavonoid content of 4.83 mg/g. Abstrak: Pandemi COVID-19 yang sudah terjadi lebih dari dua tahun masih belum berakhir bahkan pada Januari 2022 dengan adanya varian baru yaitu omicron, jumlah kasus COVID-19 meningkat drastis. Menurut statistik, pada 25 Januari terdapat 3.559.000.464 kasus baru COVID-19 dan rata-rata 7 hari sebanyak 3.397.073 kasus. Oleh karena itu pentingnya upaya pencegahan agar terhindar dari virus COVID-19. Salah satunya dengan mengonsumsi makanan tinggi antioksidan. Beberapa buah yang tinggi antioksidan adalah buah belimbing wuluh dan buah mahkota dewa. Flavonoid merupakan salah satu jenis antioksidan yang terdapat pada buah belimbing wuluh dan buah mahkota dewa yang berfungsi menghambat pembentukan Reactive Oxygen Species (ROS) dengan menghambat enzim dalam pembentukan ROS dan meningkatkan regulasi serta proteksi dari antioksidan sehingga dapat mencegah berbagai dampak negatifnya seperti penyakit degenerative dan penurunan imunitas sehingga dapat mencegah dari terpaparnya virus COVID-19. Tujuan penelitian ini yaitu untuk mengetahui kadar flavonoid pada kombinasi ekstrak buah belimbing wuluh dan buah mahkota dewa. Metode yang digunakan yaitu metode spektrofotometri UV-VIS. Hasil penelitian ini yaitu didapatkan kadar flavonoid buah belimbing wuluh sebesar 2.32 mg/g, ekstrak buah mahkota dewa sebesar 4.83 mg/g dan kombinasi dari keduanya sebesar 4.77 mg/g. Dari hasil tersebut dapat disimpulkan bahwa ekstrak buah mahkota dewa memiliki kadar flavonoid tertinggi yaitu 4.83 mg/g.
Pentingnya Pemberian Nutrisi Secara Dini Terhadap Pasien Post-Operasi Laparotomy Perforasi Ileus Laila Sholehah
Jurnal Ilmiah Kesehatan Sandi Husada Vol 10 No 2 (2021): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v10i2.607

Abstract

Background: Digestive surgery patients are very at risk of experiencing malnutrition, this is because the gastrointestinal tract function is not optimal. Patients who have perforated ileus really need nutrients to help reduce or cope with malnutrition. This is important because malnutrition can slow down the postoperative wound healing process. Objective: to find out more about the importance of early nutrition in patients with digestive surgery, especially in patients with ileus perforations. Methods: Using literature studies from both national and international journals by summarizing the discussion topics and comparing the results presented in the article. Results: Early nutrition will lead to faster wound recovery and healing and prevent complications from occurring so that the length of stay for patients will be shorter and will indirectly reduce costs incurred for patient treatment. Conclusion: There is an effect of early nutrition in patients after ileus perforation surgery
Co-Authors Arief Nurudhin Arief Nurudhin Arief Nurudhin Shanti Listyawati Shanti Listyawati Shanti Listyawati