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Arief Nurudhin
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PENGARUH SECRETOME SEL PUNCA MESENKIMAL TERHADAP EKSPRESI INTERLEUKIN-1β DAN CASPASE-1 Shiddiqi, Toumi; Adnan, Zainal Arifin; Nurudhin, Arief
Biomedika Vol 9, No 2 (2017): Biomedika Agustus 2017
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v9i2.5840

Abstract

Systemic Lupus Erythematosus adalah penyakit inflamasi autoimun kronis dengan manifestasi klinis  beragam dan luas. Pemberian injeksi pristan intraperitoneal dapat menginduksi lupus pada mencit. IL-1β merupakan sitokin inflamasi yang berperan pada patogenesis SLE melalui jalur Caspase-1. Secretome sel punca mesenkimal mengandung Stanniocalcin-1 yang berperan sebagai antiinflamasi. Tujuan Penelitian adalah untuk mengetahui pengaruh secretome sel punca mesenkimal terhadap ekspresi IL-1β dan Caspase-1  pada mencit model lupus dengan induksi pristan. Penelitian eksperimental dengan metode post test only control group design, sampel 21 ekor mencit betina Mus Musculus galur Balb/C, dibagi 3 kelompok yaitu kelompok kontrol (injeksi intraperitoneal NaCl 0,9% 0,5 ml), kelompok pristan (injeksi pristan intraperitoneal 0,5 ml) dan kelompok pristan+secretome (injeksi intraperitoneal pristan 0,5 ml dan secretome 0,45 ml). Penelitian dilakukan selama 3 minggu, secretome diberikan pada akhir penelitian. Dinilai ekspresi IL-1β dan Caspase-1 secara imunohistokimia. Analisis  statistik menggunakan IBM SPSS 20 dengan uji ANOVA dilanjutkan uji post hoc LSD. P bermakna jika p<0,05. Hasil penelitian menunjukkan rata-rata ekspresi IL-1β pada ketiga kelompok yaitu kontrol (22,75±8,30); pristan (79,67±18,24); pristan+secretome (19,94±6,41), dengan kemaknaan p=0,000. Terdapat perbedaan bermakna ekspresi IL-1β antara kelompok kontrol vs pristan (-56,92±6,69; p=0,000), kelompok pristan vs pristan+secretome (61,31±6,69; p=0,000). Rata-rata ekspresi Caspase-1 pada ketiga kelompok yaitu kontrol(17,04±6,30); pristan (81,25±17,32); pristan+secretome (21,97±12,59), dengan kemaknaan p=0.000. Terdapat perbedaan bermakna ekspresi Caspase-1 antara kelompok kontrol vs pristan (-64,21±6,69; p=0,000) dan kelompok pristan vs pristan+secretome (59,28±6,69; p=0,000).Simpulan yang dapat diambil adalah  secretome sel punca mesenkimal menurunkan ekspresi IL-1β dan Caspase-1 pada mencit model lupus dengan induksi pristan.Kata Kunci: Caspase-1, Interleukin-1β, Pristan, Secretome, Systemic Lupus Erythematosus.
MODULASI SEL PUNCA MESENKIMAL DALAM MENURUNKAN KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN SEBAGAI TERAPI NEFRITIS LUPUS Maharani, Indah Putri; Adnan, Zainal Arifin; Nurudhin, Arief
Biomedika Vol 9, No 1 (2017): Biomedika Februari 2017
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v9i1.4340

Abstract

Systemic Lupus Erythematosus merupakan penyakit inflamasi autoimun kronis dengan gambaran klinis luas dan perjalanan penyakit beragam. Pemberian pristan intraperitoneal dapat menginduksi lupus pada mencit. Secretome sel punca mesenkimal bekerja secara parakrin memberikan efek antinflamasi dan imunomodulasi antara lain mensupresi sel T dan sel B autoreaktif. High Sensitivity C-Reactive Protein (hsCRP) terkait dengan patogenesis SLE dan selaras dengan aktifitas penyakit.Tujuan Penelitian adalah untuk mengetahui pengaruh secretome sel punca mesenkimal terhadap kadar hsCRP pada mencit model lupus dengan induksi pristan. Desain penelitian adalah eksperimental dengan randomisasi, post test only control group design, sampel 21 ekor mencit betina Mus Musculus galur Balb/C, dibagi 3 kelompok yaitu kelompok kontrol (injeksi intraperitoneal NaCl 0,9% 0,5 ml), kelompok perlakuan (injeksi pristan intraperitoneal 0,5 ml) dan kelompok terapi (injeksi intraperitoneal pristan 0,5 ml dan secretome 0,45 ml). Penelitian dilakukan selama 3 minggu, secretome diberikan pada akhir penelitian. Sesudah perlakuan dinilai kadar hsCRP secara ELISA. Analisis statistik menggunakan SPSS 22 for windows dengan uji Kruskal-Wallis dilanjutkan Mann-Whitney U test. P bermakna jika p<0,05. Hasil penelitian menunjukkan bahwa rata-rata kadar hsCRP pada ketiga kelompok yaitu kontrol 440.68(110.08-564.29) ng/ mL; perlakuan (pristan) 2964.26(601.13-3926.10) ng/mL; terapi pristan+secretome) 506.93(207.62-1473.46) ng/mL, dengan kemaknaan p=0.008. Terdapat perbedaan bermakna kadar hsCRP antara kelompok pristan vs pristan+secretome (2457.33 ng/mL; p=0.047). Secretome sel punca mesenkimal mampu menurunkan kadar hsCRP pada mencit model lupus dengan induksi pristan.Kata Kunci: High Sensitivity C-Reactive Protein, Nefritis lupus, Secretome
MODULASI SEL PUNCA MESENKIMAL DALAM MENURUNKAN KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN SEBAGAI TERAPI NEFRITIS LUPUS Indah Putri Maharani; Zainal Arifin Adnan; Arief Nurudhin
Biomedika Vol 9, No 1 (2017): Biomedika Februari 2017
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v9i1.4340

Abstract

Systemic Lupus Erythematosus merupakan penyakit inflamasi autoimun kronis dengan gambaran klinis luas dan perjalanan penyakit beragam. Pemberian pristan intraperitoneal dapat menginduksi lupus pada mencit. Secretome sel punca mesenkimal bekerja secara parakrin memberikan efek antinflamasi dan imunomodulasi antara lain mensupresi sel T dan sel B autoreaktif. High Sensitivity C-Reactive Protein (hsCRP) terkait dengan patogenesis SLE dan selaras dengan aktifitas penyakit.Tujuan Penelitian adalah untuk mengetahui pengaruh secretome sel punca mesenkimal terhadap kadar hsCRP pada mencit model lupus dengan induksi pristan. Desain penelitian adalah eksperimental dengan randomisasi, post test only control group design, sampel 21 ekor mencit betina Mus Musculus galur Balb/C, dibagi 3 kelompok yaitu kelompok kontrol (injeksi intraperitoneal NaCl 0,9% 0,5 ml), kelompok perlakuan (injeksi pristan intraperitoneal 0,5 ml) dan kelompok terapi (injeksi intraperitoneal pristan 0,5 ml dan secretome 0,45 ml). Penelitian dilakukan selama 3 minggu, secretome diberikan pada akhir penelitian. Sesudah perlakuan dinilai kadar hsCRP secara ELISA. Analisis statistik menggunakan SPSS 22 for windows dengan uji Kruskal-Wallis dilanjutkan Mann-Whitney U test. P bermakna jika p0,05. Hasil penelitian menunjukkan bahwa rata-rata kadar hsCRP pada ketiga kelompok yaitu kontrol 440.68(110.08-564.29) ng/ mL; perlakuan (pristan) 2964.26(601.13-3926.10) ng/mL; terapi pristan+secretome) 506.93(207.62-1473.46) ng/mL, dengan kemaknaan p=0.008. Terdapat perbedaan bermakna kadar hsCRP antara kelompok pristan vs pristan+secretome (2457.33 ng/mL; p=0.047). Secretome sel punca mesenkimal mampu menurunkan kadar hsCRP pada mencit model lupus dengan induksi pristan.Kata Kunci: High Sensitivity C-Reactive Protein, Nefritis lupus, Secretome
PENGARUH SECRETOME SEL PUNCA MESENKIMAL TERHADAP EKSPRESI INTERLEUKIN-1β DAN CASPASE-1 Toumi Shiddiqi; Zainal Arifin Adnan; Arief Nurudhin
Biomedika Vol 9, No 2 (2017): Biomedika Agustus 2017
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v9i2.5840

Abstract

Systemic Lupus Erythematosus adalah penyakit inflamasi autoimun kronis dengan manifestasi klinis  beragam dan luas. Pemberian injeksi pristan intraperitoneal dapat menginduksi lupus pada mencit. IL-1β merupakan sitokin inflamasi yang berperan pada patogenesis SLE melalui jalur Caspase-1. Secretome sel punca mesenkimal mengandung Stanniocalcin-1 yang berperan sebagai antiinflamasi. Tujuan Penelitian adalah untuk mengetahui pengaruh secretome sel punca mesenkimal terhadap ekspresi IL-1β dan Caspase-1  pada mencit model lupus dengan induksi pristan. Penelitian eksperimental dengan metode post test only control group design, sampel 21 ekor mencit betina Mus Musculus galur Balb/C, dibagi 3 kelompok yaitu kelompok kontrol (injeksi intraperitoneal NaCl 0,9% 0,5 ml), kelompok pristan (injeksi pristan intraperitoneal 0,5 ml) dan kelompok pristan+secretome (injeksi intraperitoneal pristan 0,5 ml dan secretome 0,45 ml). Penelitian dilakukan selama 3 minggu, secretome diberikan pada akhir penelitian. Dinilai ekspresi IL-1β dan Caspase-1 secara imunohistokimia. Analisis  statistik menggunakan IBM SPSS 20 dengan uji ANOVA dilanjutkan uji post hoc LSD. P bermakna jika p0,05. Hasil penelitian menunjukkan rata-rata ekspresi IL-1β pada ketiga kelompok yaitu kontrol (22,75±8,30); pristan (79,67±18,24); pristan+secretome (19,94±6,41), dengan kemaknaan p=0,000. Terdapat perbedaan bermakna ekspresi IL-1β antara kelompok kontrol vs pristan (-56,92±6,69; p=0,000), kelompok pristan vs pristan+secretome (61,31±6,69; p=0,000). Rata-rata ekspresi Caspase-1 pada ketiga kelompok yaitu kontrol(17,04±6,30); pristan (81,25±17,32); pristan+secretome (21,97±12,59), dengan kemaknaan p=0.000. Terdapat perbedaan bermakna ekspresi Caspase-1 antara kelompok kontrol vs pristan (-64,21±6,69; p=0,000) dan kelompok pristan vs pristan+secretome (59,28±6,69; p=0,000).Simpulan yang dapat diambil adalah  secretome sel punca mesenkimal menurunkan ekspresi IL-1β dan Caspase-1 pada mencit model lupus dengan induksi pristan.Kata Kunci: Caspase-1, Interleukin-1β, Pristan, Secretome, Systemic Lupus Erythematosus.
Flavonoid Content Combination of Averrhoa bilimbi L and Phaleria macrocarpa Fruit Extract as Chemoprevention Agent against COVID-19 Sholehah, Laila; Listyawati, Shanti; Nurudhin, Arief
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No S1 (2022): Suplement 1
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1258.362 KB) | DOI: 10.30604/jika.v7iS1.1077

Abstract

The covid pandemic that has occurred for more than two years is still not over. Even in January 2022, with the new variant, Omicron, the number of COVID-19 cases has increased dramatically. According to statistics, on January 25 there were 3,559,000,464 new cases of COVID-19 and an average of 7 days as many as 3,397,073 cases. Therefore, it is important to take preventive measures to avoid the COVID-19 virus. One of them by eating foods high in antioxidants. Some fruits that are high in antioxidants are Averrhoa bilimbi L and Phaleria macrocarpa. Flavonoids are one of the types of antioxidants found in Averrhoa bilimbi L and Phaleria macrocarpa which function to inhibit the formation of Reactive Oxygen Species (ROS) by inhibiting enzymes in the formation of ROS and increasing the regulation and protection of antioxidants to prevent various negative impacts such as degenerative diseases and decreased immunity so that it can prevent exposure to the COVID-19 virus. The purpose of this study was to determine the levels of flavonoids in the combination of extracts of Averrhoa bilimbi L and Phaleria macrocarpa. The method used is the UV-VIS spectrophotometry method. The result of this research is that the flavonoid content of Averrhoa bilimbi L is 2.32 mg/g, the extract of Phaleria macrocarpa is 4.83 mg/g and the combination of the two is 4.77 mg/g. From these results, it can be said that the extract of Phaleria macrocarpa has the highest flavonoid content of 4.83 mg/g. Abstrak: Pandemi COVID-19 yang sudah terjadi lebih dari dua tahun masih belum berakhir bahkan pada Januari 2022 dengan adanya varian baru yaitu omicron, jumlah kasus COVID-19 meningkat drastis. Menurut statistik, pada 25 Januari terdapat 3.559.000.464 kasus baru COVID-19 dan rata-rata 7 hari sebanyak 3.397.073 kasus. Oleh karena itu pentingnya upaya pencegahan agar terhindar dari virus COVID-19. Salah satunya dengan mengonsumsi makanan tinggi antioksidan. Beberapa buah yang tinggi antioksidan adalah buah belimbing wuluh dan buah mahkota dewa. Flavonoid merupakan salah satu jenis antioksidan yang terdapat pada buah belimbing wuluh dan buah mahkota dewa yang berfungsi menghambat pembentukan Reactive Oxygen Species (ROS) dengan menghambat enzim dalam pembentukan ROS dan meningkatkan regulasi serta proteksi dari antioksidan sehingga dapat mencegah berbagai dampak negatifnya seperti penyakit degenerative dan penurunan imunitas sehingga dapat mencegah dari terpaparnya virus COVID-19. Tujuan penelitian ini yaitu untuk mengetahui kadar flavonoid pada kombinasi ekstrak buah belimbing wuluh dan buah mahkota dewa. Metode yang digunakan yaitu metode spektrofotometri UV-VIS. Hasil penelitian ini yaitu didapatkan kadar flavonoid buah belimbing wuluh sebesar 2.32 mg/g, ekstrak buah mahkota dewa sebesar 4.83 mg/g dan kombinasi dari keduanya sebesar 4.77 mg/g. Dari hasil tersebut dapat disimpulkan bahwa ekstrak buah mahkota dewa memiliki kadar flavonoid tertinggi yaitu 4.83 mg/g.
AKTIVITAS FISIK DAN AKTIVASI RUMAH SINGGAH MENINGKATKAN KUALITAS HIDUP PASIEN LUPUS Nurudhin, Arief; Werdiningsih, Yulyani; Prabowo, Nurhasan Agung; Sunarso, Indrayana
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 4 No. 6 (2023): Volume 4 Nomor 6 Tahun 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v4i6.23378

Abstract

Penyakit Lupus Eritematosus Sistemik (LES) merupakan suatu penyakit autoimun yang bersifat kronis dan menyebabkan nyeri pada semua ODAPUS (Orang dengan Lupus). Intervensi psikososial bertujuan untuk mengurangi rasa sakit serta meningkatkan kualitas hidup para ODAPUS. Nyeri dipengarui olehberbagai faktro salah satunya adalah faktor psikologis. Hasil analisis situasi menunjukkan bahwa nyeri menjadi masalah utama yang sering dialami oleh ODAPUS, meskipun mereka sudah rutin minum obat. Oleh karena itu, diperlukan pendekatan lain untuk mengurangi nyeri ini. Pengabdian kepada masyarakat ini bertujuan untuk meningkakan kualitas hidup pasien lupus melalui pendekatan edukasi yang berbasis komunitas.Metode pelaksanaan pengabdian ini menggunakan ceramah, diskusi, Outbond dan perbaikan rumah singgahpada ODAPUS yang merupakan anggota Yayasan Tittari. Kegiatan pengabdian dilaksanakan di Rumah Singgah Yayasan Tittari dan juga Area Danau UNS. Materi yang diangkat dalam pengabdian ini mencakup pengetahuan tentang nyeri bagi ODAPUS, metode sederhana untuk mengurangi tingkat nyeri, serta pentingnya memahami peran depresi, stres, dan ansietas dalam menyebabkan nyeri. Serta Perbaikan rumah singgah yang mengalami kerusakan selama pandemi COVID 19. Diharapkan melalui pendekatan eduksi dan perbaikan sarana rumah singgah dapat memperbaiki kualitas hidup pasien Lupus.Pemateri pada kegiatan ini adalah seorang dokter ahli nyeri rematologi. Jumlah peserta ODAPUS yang mengikuti kegiatan ini berjumlah 70 orang. Evaluasi hasil kegiatan dilakukan dengan membandingkan skor Lupus QOL Sebelum dan dalam rentang 2 bulan sesudah kegiatan. Kuisioner diedarkan secara online melaui GForm. Hasil mengabdian didapatkan adanya peningkatan Skor LupusQoL dalam beberbagai domain, serta signifikan secara statistik. .Hal ini menunjukkan adanya edukasi berbasis kominitas dan perbaikan sarana rumah singgah memperbaiki kualitas hidup ODAPUS yang terlibat kegiatan tersebut.
Beetroot (Beta vulgaris L.) reduces cholesterol and triglyceride in dyslipidemic male rats sprague–dawley model Rohman, Yulia; Nurudhin, Arief; Wardhani, Lusi Oka
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 12, No 2 (2024): June
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.12.2.80-87

Abstract

Background: High-fat diets habit can lead to metabolic disorders, such as dyslipidemia which a significant contributor for cardiovascular diseases. Dyslipidemia occurs as a result of metabolically interrelated abnormalities of plasma lipids and lipoproteins, including low level of high-density lipoprotein cholesterol, and increasing of low density lipoprotein cholesterol, total cholesterol, and triglyceride. In order to enhance anti-lipid treatment, nutritional therapy containing bioactive compounds are investigated extensively, including those found in beetroot which shown potential in preventing and treating metabolic disorders.Objective: This study evaluated the effect of beetroot extract and beetroot juice on cholesterol and triglyceride levels as a dyslipidemia treatment, in comparison to simvastatin. Ethanol extract can attract flavonoids and betalain, but the extraction process can degrade fiber. Meanwhile, juice still contains quite a lot of fiber.Materials and Methods: Male Sprague Dawley rats were divided into seven groups and fed different diets for 56 days. The groups were: normal control (K0), negative control-HFD (KN), positive control-HFD + simvastatin (KP), single-dose treatment with BE (P1) or BJ (P2), and combination treatment with BE or BJ + simvastatin (P3 and P4), each intervention was given for 28 days. After blood drawn, cholesterol total and triglyceride serum were examined and analyzed.Results: Administration of beetroot extract and juice in single dose or combination with simvastatin gave a significant decrease in cholesterol and triglyceride levels compared to before the intervention. The average reduction levels of cholesterol in P1, P2, P3, and P4 were 54.81, 56.31, 94.19 and 69.11 respectively. Whereas the average decreasing level of triglyceride were 43.28, 30.78, 54.28 and 46.37 in P1, P2, P3 and P4 groups. Combination treatment with simvastatin gave more reduction level compared with single dose beetroot extract or beetroot juice. The most effective reduction was in the beet extract combination with simvastatin group were -94.19±4.08 mg/dL (cholesterol) and -54.28±6.93 mg/dL (triglyceride).Conclusion: Both beetroot extract and juice, as single or combined with simvastatin, were able to decrease cholesterol and triglyceride levels, these indicated their potential for prevention and therapeutic in dyslipidemia. Further research is needed to investigate its mechanisms and establish optimal dosages for human consumption.
Umbilical cord mesenchymal stem cell-derived secretome as a potential treatment for systemic lupus erythematosus: A double-blind randomized controlled trial Nurudhin, Arief; Werdiningsih, Yulyani; Sunarso, Indrayana; Marwanta, Sri; Damayani, Aritantri; Prabowo, Nurhasan A.; Affandi, Andri; Gazali, Itqan; Safitri, Ayu SI.; Sidarta, Brigitte RA.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1799

Abstract

Umbilical cord mesenchymal stem cell-derived (UCMSC-derived) secretome is anti-apoptotic, anti-inflammatory, antifibrotic, angiogenic, and tissue-regenerating. Thus, it may treat systemic lupus erythematosus (SLE). The aim of this study was to investigate the impact of the UCMSC-derived secretome on SLE patients' disease activity, using Mexican systemic lupus erythematosus disease activity index (MEX-SLEDAI) score, complement (C3 and C4) levels, tumor necrosis factor-alpha (TNF-α), anti-double-stranded DNA (anti-dsDNA), and interleukin-6 (IL-6) levels. This double-blind randomized controlled trial investigated the efficacy and safety of UCMSC-derived secretome in SLE patients with moderate disease activity. A total of 29 female patients were randomized into two groups to receive weekly 1.5 cc intramuscular injections of UCMSC-derived secretome or placebo (0.9% NaCl) for six weeks. Disease activity was assessed using the MEX-SLEDAI score, C3 and C4 levels, pro-inflammatory cytokines (IL-6 and TNF-α), and anti-dsDNA antibodies at baseline, Day 22, and Day 43. Results showed a significant reduction in MEX-SLEDAI scores in the secretome group compared to the placebo group (p<0.05). Complement C3 levels significantly increased in the secretome group on Day 43, indicating improved immune homeostasis, while C4 levels did not show significant differences between groups. IL-6 and TNF-α levels showed decreasing trends in the secretome group. Anti-dsDNA levels exhibited a decreasing trend in the secretome group, though not statistically significant. Importantly, no severe adverse events were observed, underscoring the safety of the intervention. UCMSC-derived secretome demonstrated immunomodulatory and anti-inflammatory effects, reducing disease activity in SLE patients. These findings suggest its potential as a safe and effective adjunct therapy for SLE, although further studies with larger sample sizes and extended follow-up periods are needed to validate these results.
Mesenchymal Stem Cell Secretome Improves Bone Quality in Autoimmune Rheumatic Patients (AIIRD): A Case Report Werdiningsih, Yulyani; Nurudhin, Arief; sunarso, indrayana
Indonesian Basic and Experimental Health Sciences Vol. 13 No. 1 (2024): November
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol13iss1pp11-15

Abstract

ABSTRAK Autoimmune Inflammatory Rheumatic Disease (AIIRD) is a group of different disorders, which have similar clinical, laboratory and immunological manifestations. In East Asia, the top 3 diseases included in AIIRD are Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Sjogren's Syndrome. Glucocorticoids are still one of the therapeutic modalities for AIIIRD with their antiinflammatory and immunosuppressive effects. However, glucocorticoids have some side effects. One side effect of concern is decreased bone density. The condition of glucocorticoid induced osteoporosis (GIOP) is reported with increasing prevalence. The main effect of the use of glucocorticoids on bones is the presence of impaired bone formation regardless of the role of inflammation.  Secretome stem cells contain bioactives that exhibit diverse physiological functions such as immunomodulation, anti-inflammatory, angiogenesis, anti-apoptotic and anti-oxidation. Secretome can modulate cell differentiation by promoting osteogenesis and inhibiting adipogenesis. In this case report, it showed improvements in markers of bone damage, inflamation, and vitamin D levels after stem cell secretome administration in AIIRD patients with long-term corticosteroid use.
Effect of the Period of Glucocorticoid Administration on Bone Quality in Patients with Autoimmune Inflammatory Rheumatism Disease (AIIRD) Werdiningsih, Yulyani; Sunarso, indrayana; Nurudhin, Arief
Indonesian Basic and Experimental Health Sciences Vol. 13 No. 2 (2025): APRIL
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol13iss2pp52-58

Abstract

Introduction Inflammatory autoimmune rheumatic disease (AIIRD) such as rheumatoid arthritis, systemic lupus erythematosus, and Sjogren's syndrome often requires long-term glucocorticoid therapy. Despite its effectiveness, glucocorticoids are recognized to cause decreased bone quality and increase the risk of osteoporosis. This study aims to evaluate the effect of the period of glucocorticoid administration on bone quality parameters in AIIRD patients. Methods This study was an observational analytical study with a cross-sectional design. A total of 28 female patients with AIIRD were divided into two groups based on the period of glucocorticoid administration: less than 24 months and more than 24 months. The parameters to be measured included bone mineral density (BMD), Collagen Type I C-Telopeptide (CTX), Vitamin D3 levels, and Calcium Ions. Data analysis was conducted using the Mann-Whitney test and the unpaired t-test with a significance level of p<0.05. Results There was no statistically significant difference between the two groups on all measured parameters. The mean BMD in the group of less than 24 months was 0.9471 kg/m², while in the group of more than 24 months it was 0.8920 kg/m² (p>0.05). The mean CTX also did not differ significantly between the two groups (0.2474 vs. 0.2508 ng/mL; p>0.05). Vitamin D3 and Calcium Ion levels showed similar results in the absence of significant differences (Vitamin D3: 15,596 vs. 16,255 ng/mL; Calcium Ion: 1,075 vs. 1,040 mmol/L; p>0.05). Conclusions The period of glucocorticoid administration does not show a significant effect on bone quality in AIIRD patients in this study. Nonetheless, regular monitoring and an individualized approach are still necessary to prevent bone complications in patients receiving long-term glucocorticoid therapy.
Co-Authors Adnan, Zainal Arifin Adnan, Zainal Arifin Affandi, Andri Akrim Permitasari Arifin Arifin Ayu Safira, Meilani Bagus Wicaksono BAGUS WICAKSONO Damayani, Aritantri Eti Poncorini Pamungkasari Gazali, Itqan Indah Putri Maharani Karim, Muhammad Yusuf Maharani, Indah Putri Marwanta, Sri Nurhayatun, Evi Prabowo, Nurhasan A. Prabowo, Nurhasan Agung Rohman, Yulia Safitri, Ayu SI. Shanti Listyawati Shiddiqi, Toumi Sholehah, Laila Sidarta, Brigitte RA. Sulastomo, Heru Sunarso, Indrayana Toumi Shiddiqi Triyanta Yuli Pramana Wardhani, Lusi Oka Wedhiningsih, Yulyani Werdiningsih, Yulyani Wulandari, Evi Liliek Zainal Arifin Adnan