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Hubungan antara Optimisme dengan Kualitas Hidup pada Pasien Lupus Eritematosus Permitasari, Akrim; Nurudhin, Arief; Wicaksono, Bagus
Nexus Kedokteran Klinik Vol 3, No 3 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.046 KB)

Background: Systemic Lupus Erythematosus (SLE) is an auto-immune disease that is vary since its relapse period (flare) and remission period. The occurence of flare on SLE consist of many factors, one of them is depression that is caused by stress. While, the optimists are known as people who have good ability on dealing with stress. This research is aimed to find out the relation between optimism and living quality of patients who suffered from SLE. Research Method: This research was an analytic observational research with cross sectional approach. The sample was SLE patients who are fused in Griya Kupu Surakarta community. This research conducted by filling out the quetionnaires, optimism quetionnaire (Life Orientation Test-Revised) and quality of life quetionnaire (SF-36). From these two data, the researcher did the analysis using Pearsonâs product moment correlation analysis. Then, the data were treated by using SPSS 14,0 for Windows application. Result: Based on the analysis, there were some result obtained: there was a strong unidirectional relation (r = 0,613) and significant (sig = 0,000) between optimism and quality of life. There was varied relationship between optimism and quality of life on each domain. Optimism had strong unidirectional relation on physical function domain (r = 0,515, sig = 0,003), pain domain (r = 0,570, sig = 0,001), social function domain (r = 0,602, sig = 0,000) and general health (r = 0,614, sig = 0,000). Optimism had quite strong unidirectional relation with physical role domain (r = 0,329, sig = 0,071), the role of emotion domain (r = 0,429, sig = 0,016) and energy domain (r = 0,498, sig = 0,004). But, on physical role domain (sig = 0,071) this result was not significant.Â Optimism had inversely relation with mental health (r = -0,318, sig = 0,087), this result was not significant. Conclusion: Based on this research, it can be concluded that there is a strong relation (r = 0,613, sig = 0,000) between optimism and quality of life of Systemic Lupus ErythematosusÂ patients. Key Words: Systemic Lupus Erythematosus, Optimism, Quality of LifeÂ

PENGARUH SECRETOME SEL PUNCA MESENKIMAL TERHADAP EKSPRESI INTERLEUKIN-1Î² DAN CASPASE-1 Shiddiqi, Toumi; Adnan, Zainal Arifin; Nurudhin, Arief
Biomedika Vol 9, No 2 (2017): Biomedika Agustus 2017
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v9i2.5840

Systemic Lupus Erythematosus adalah penyakit inflamasi autoimun kronis dengan manifestasi klinis Â beragam dan luas. Pemberian injeksi pristan intraperitoneal dapat menginduksi lupus pada mencit. IL-1Î² merupakan sitokin inflamasi yang berperan pada patogenesis SLE melalui jalur Caspase-1. Secretome sel punca mesenkimal mengandung Stanniocalcin-1 yang berperan sebagai antiinflamasi. Tujuan Penelitian adalah untuk mengetahui pengaruh secretome sel punca mesenkimal terhadap ekspresi IL-1Î² dan Caspase-1Â pada mencit model lupus dengan induksi pristan. Penelitian eksperimental dengan metode post test only control group design, sampel 21 ekor mencit betina Mus Musculus galur Balb/C, dibagi 3 kelompok yaitu kelompok kontrol (injeksi intraperitoneal NaCl 0,9% 0,5 ml), kelompok pristan (injeksi pristan intraperitoneal 0,5 ml) dan kelompok pristan+secretome (injeksi intraperitoneal pristan 0,5 ml dan secretome 0,45 ml). Penelitian dilakukan selama 3 minggu, secretome diberikan pada akhir penelitian. Dinilai ekspresi IL-1Î² dan Caspase-1 secara imunohistokimia. AnalisisÂ statistik menggunakan IBM SPSS 20 dengan uji ANOVA dilanjutkan uji post hoc LSD. P bermakna jika p<0,05. Hasil penelitian menunjukkan rata-rata ekspresi IL-1Î² pada ketiga kelompok yaitu kontrol (22,75Â±8,30); pristan (79,67Â±18,24); pristan+secretome (19,94Â±6,41), dengan kemaknaan p=0,000. Terdapat perbedaan bermakna ekspresi IL-1Î² antara kelompok kontrol vs pristan (-56,92Â±6,69; p=0,000), kelompok pristan vs pristan+secretome (61,31Â±6,69; p=0,000). Rata-rata ekspresi Caspase-1 pada ketiga kelompok yaitu kontrol(17,04Â±6,30); pristan (81,25Â±17,32); pristan+secretome (21,97Â±12,59), dengan kemaknaan p=0.000. Terdapat perbedaan bermakna ekspresi Caspase-1 antara kelompok kontrol vs pristan (-64,21Â±6,69; p=0,000) dan kelompok pristan vs pristan+secretome (59,28Â±6,69; p=0,000).Simpulan yang dapat diambil adalahÂ secretome sel punca mesenkimal menurunkan ekspresi IL-1Î² dan Caspase-1 pada mencit model lupus dengan induksi pristan.Kata Kunci: Caspase-1, Interleukin-1Î², Pristan, Secretome, Systemic Lupus Erythematosus.

MODULASI SEL PUNCA MESENKIMAL DALAM MENURUNKAN KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN SEBAGAI TERAPI NEFRITIS LUPUS Maharani, Indah Putri; Adnan, Zainal Arifin; Nurudhin, Arief
Biomedika Vol 9, No 1 (2017): Biomedika Februari 2017
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v9i1.4340

Systemic Lupus Erythematosus merupakan penyakit inflamasi autoimun kronis dengan gambaran klinis luas dan perjalanan penyakit beragam. Pemberian pristan intraperitoneal dapat menginduksi lupus pada mencit. Secretome sel punca mesenkimal bekerja secara parakrin memberikan efek antinflamasi dan imunomodulasi antara lain mensupresi sel T dan sel B autoreaktif. High Sensitivity C-Reactive Protein (hsCRP) terkait dengan patogenesis SLE dan selaras dengan aktifitas penyakit.Tujuan Penelitian adalah untuk mengetahui pengaruh secretome sel punca mesenkimal terhadap kadar hsCRP pada mencit model lupus dengan induksi pristan. Desain penelitian adalah eksperimental dengan randomisasi, post test only control group design, sampel 21 ekor mencit betina Mus Musculus galur Balb/C, dibagi 3 kelompok yaitu kelompok kontrol (injeksi intraperitoneal NaCl 0,9% 0,5 ml), kelompok perlakuan (injeksi pristan intraperitoneal 0,5 ml) dan kelompok terapi (injeksi intraperitoneal pristan 0,5 ml dan secretome 0,45 ml). Penelitian dilakukan selama 3 minggu, secretome diberikan pada akhir penelitian. Sesudah perlakuan dinilai kadar hsCRP secara ELISA. Analisis statistik menggunakan SPSS 22 for windows dengan uji Kruskal-Wallis dilanjutkan Mann-Whitney U test. P bermakna jika p<0,05. Hasil penelitian menunjukkan bahwa rata-rata kadar hsCRP pada ketiga kelompok yaitu kontrol 440.68(110.08-564.29) ng/ mL; perlakuan (pristan) 2964.26(601.13-3926.10) ng/mL; terapi pristan+secretome) 506.93(207.62-1473.46) ng/mL, dengan kemaknaan p=0.008. Terdapat perbedaan bermakna kadar hsCRP antara kelompok pristan vs pristan+secretome (2457.33 ng/mL; p=0.047). Secretome sel punca mesenkimal mampu menurunkan kadar hsCRP pada mencit model lupus dengan induksi pristan.Kata Kunci: High Sensitivity C-Reactive Protein, Nefritis lupus, Secretome

MODULASI SEL PUNCA MESENKIMAL DALAM MENURUNKAN KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN SEBAGAI TERAPI NEFRITIS LUPUS Indah Putri Maharani; Zainal Arifin Adnan; Arief Nurudhin
Biomedika Vol 9, No 1 (2017): Biomedika Februari 2017
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v9i1.4340

Systemic Lupus Erythematosus merupakan penyakit inflamasi autoimun kronis dengan gambaran klinis luas dan perjalanan penyakit beragam. Pemberian pristan intraperitoneal dapat menginduksi lupus pada mencit. Secretome sel punca mesenkimal bekerja secara parakrin memberikan efek antinflamasi dan imunomodulasi antara lain mensupresi sel T dan sel B autoreaktif. High Sensitivity C-Reactive Protein (hsCRP) terkait dengan patogenesis SLE dan selaras dengan aktifitas penyakit.Tujuan Penelitian adalah untuk mengetahui pengaruh secretome sel punca mesenkimal terhadap kadar hsCRP pada mencit model lupus dengan induksi pristan. Desain penelitian adalah eksperimental dengan randomisasi, post test only control group design, sampel 21 ekor mencit betina Mus Musculus galur Balb/C, dibagi 3 kelompok yaitu kelompok kontrol (injeksi intraperitoneal NaCl 0,9% 0,5 ml), kelompok perlakuan (injeksi pristan intraperitoneal 0,5 ml) dan kelompok terapi (injeksi intraperitoneal pristan 0,5 ml dan secretome 0,45 ml). Penelitian dilakukan selama 3 minggu, secretome diberikan pada akhir penelitian. Sesudah perlakuan dinilai kadar hsCRP secara ELISA. Analisis statistik menggunakan SPSS 22 for windows dengan uji Kruskal-Wallis dilanjutkan Mann-Whitney U test. P bermakna jika p0,05. Hasil penelitian menunjukkan bahwa rata-rata kadar hsCRP pada ketiga kelompok yaitu kontrol 440.68(110.08-564.29) ng/ mL; perlakuan (pristan) 2964.26(601.13-3926.10) ng/mL; terapi pristan+secretome) 506.93(207.62-1473.46) ng/mL, dengan kemaknaan p=0.008. Terdapat perbedaan bermakna kadar hsCRP antara kelompok pristan vs pristan+secretome (2457.33 ng/mL; p=0.047). Secretome sel punca mesenkimal mampu menurunkan kadar hsCRP pada mencit model lupus dengan induksi pristan.Kata Kunci: High Sensitivity C-Reactive Protein, Nefritis lupus, Secretome

PENGARUH SECRETOME SEL PUNCA MESENKIMAL TERHADAP EKSPRESI INTERLEUKIN-1β DAN CASPASE-1 Toumi Shiddiqi; Zainal Arifin Adnan; Arief Nurudhin
Biomedika Vol 9, No 2 (2017): Biomedika Agustus 2017
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v9i2.5840

Systemic Lupus Erythematosus adalah penyakit inflamasi autoimun kronis dengan manifestasi klinis beragam dan luas. Pemberian injeksi pristan intraperitoneal dapat menginduksi lupus pada mencit. IL-1β merupakan sitokin inflamasi yang berperan pada patogenesis SLE melalui jalur Caspase-1. Secretome sel punca mesenkimal mengandung Stanniocalcin-1 yang berperan sebagai antiinflamasi. Tujuan Penelitian adalah untuk mengetahui pengaruh secretome sel punca mesenkimal terhadap ekspresi IL-1β dan Caspase-1 pada mencit model lupus dengan induksi pristan. Penelitian eksperimental dengan metode post test only control group design, sampel 21 ekor mencit betina Mus Musculus galur Balb/C, dibagi 3 kelompok yaitu kelompok kontrol (injeksi intraperitoneal NaCl 0,9% 0,5 ml), kelompok pristan (injeksi pristan intraperitoneal 0,5 ml) dan kelompok pristan+secretome (injeksi intraperitoneal pristan 0,5 ml dan secretome 0,45 ml). Penelitian dilakukan selama 3 minggu, secretome diberikan pada akhir penelitian. Dinilai ekspresi IL-1β dan Caspase-1 secara imunohistokimia. Analisis statistik menggunakan IBM SPSS 20 dengan uji ANOVA dilanjutkan uji post hoc LSD. P bermakna jika p0,05. Hasil penelitian menunjukkan rata-rata ekspresi IL-1β pada ketiga kelompok yaitu kontrol (22,75±8,30); pristan (79,67±18,24); pristan+secretome (19,94±6,41), dengan kemaknaan p=0,000. Terdapat perbedaan bermakna ekspresi IL-1β antara kelompok kontrol vs pristan (-56,92±6,69; p=0,000), kelompok pristan vs pristan+secretome (61,31±6,69; p=0,000). Rata-rata ekspresi Caspase-1 pada ketiga kelompok yaitu kontrol(17,04±6,30); pristan (81,25±17,32); pristan+secretome (21,97±12,59), dengan kemaknaan p=0.000. Terdapat perbedaan bermakna ekspresi Caspase-1 antara kelompok kontrol vs pristan (-64,21±6,69; p=0,000) dan kelompok pristan vs pristan+secretome (59,28±6,69; p=0,000).Simpulan yang dapat diambil adalah secretome sel punca mesenkimal menurunkan ekspresi IL-1β dan Caspase-1 pada mencit model lupus dengan induksi pristan.Kata Kunci: Caspase-1, Interleukin-1β, Pristan, Secretome, Systemic Lupus Erythematosus.

Hubungan antara Optimisme dengan Kualitas Hidup pada Pasien Lupus Eritematosus Akrim Permitasari; Arief Nurudhin; Bagus Wicaksono
Nexus Kedokteran Klinik Vol 3, No 3 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.046 KB)

Background: Systemic Lupus Erythematosus (SLE) is an auto-immune disease that is vary since its relapse period (flare) and remission period. The occurence of flare on SLE consist of many factors, one of them is depression that is caused by stress. While, the optimists are known as people who have good ability on dealing with stress. This research is aimed to find out the relation between optimism and living quality of patients who suffered from SLE. Research Method: This research was an analytic observational research with cross sectional approach. The sample was SLE patients who are fused in Griya Kupu Surakarta community. This research conducted by filling out the quetionnaires, optimism quetionnaire (Life Orientation Test-Revised) and quality of life quetionnaire (SF-36). From these two data, the researcher did the analysis using Pearsons product moment correlation analysis. Then, the data were treated by using SPSS 14,0 for Windows application. Result: Based on the analysis, there were some result obtained: there was a strong unidirectional relation (r = 0,613) and significant (sig = 0,000) between optimism and quality of life. There was varied relationship between optimism and quality of life on each domain. Optimism had strong unidirectional relation on physical function domain (r = 0,515, sig = 0,003), pain domain (r = 0,570, sig = 0,001), social function domain (r = 0,602, sig = 0,000) and general health (r = 0,614, sig = 0,000). Optimism had quite strong unidirectional relation with physical role domain (r = 0,329, sig = 0,071), the role of emotion domain (r = 0,429, sig = 0,016) and energy domain (r = 0,498, sig = 0,004). But, on physical role domain (sig = 0,071) this result was not significant. Optimism had inversely relation with mental health (r = -0,318, sig = 0,087), this result was not significant. Conclusion: Based on this research, it can be concluded that there is a strong relation (r = 0,613, sig = 0,000) between optimism and quality of life of Systemic Lupus Erythematosus patients. Key Words: Systemic Lupus Erythematosus, Optimism, Quality of Life

Flavonoid Content Combination of Averrhoa bilimbi L and Phaleria macrocarpa Fruit Extract as Chemoprevention Agent against COVID-19 Sholehah, Laila; Listyawati, Shanti; Nurudhin, Arief
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No S1 (2022): Suplement 1
Publisher : Universitas Aisyah Pringsewu

The covid pandemic that has occurred for more than two years is still not over. Even in January 2022, with the new variant, Omicron, the number of COVID-19 cases has increased dramatically. According to statistics, on January 25 there were 3,559,000,464 new cases of COVID-19 and an average of 7 days as many as 3,397,073 cases. Therefore, it is important to take preventive measures to avoid the COVID-19 virus. One of them by eating foods high in antioxidants. Some fruits that are high in antioxidants are Averrhoa bilimbi L and Phaleria macrocarpa. Flavonoids are one of the types of antioxidants found in Averrhoa bilimbi L and Phaleria macrocarpa which function to inhibit the formation of Reactive Oxygen Species (ROS) by inhibiting enzymes in the formation of ROS and increasing the regulation and protection of antioxidants to prevent various negative impacts such as degenerative diseases and decreased immunity so that it can prevent exposure to the COVID-19 virus. The purpose of this study was to determine the levels of flavonoids in the combination of extracts of Averrhoa bilimbi L and Phaleria macrocarpa. The method used is the UV-VIS spectrophotometry method. The result of this research is that the flavonoid content of Averrhoa bilimbi L is 2.32 mg/g, the extract of Phaleria macrocarpa is 4.83 mg/g and the combination of the two is 4.77 mg/g. From these results, it can be said that the extract of Phaleria macrocarpa has the highest flavonoid content of 4.83 mg/g. Abstrak: Pandemi COVID-19 yang sudah terjadi lebih dari dua tahun masih belum berakhir bahkan pada Januari 2022 dengan adanya varian baru yaitu omicron, jumlah kasus COVID-19 meningkat drastis. Menurut statistik, pada 25 Januari terdapat 3.559.000.464 kasus baru COVID-19 dan rata-rata 7 hari sebanyak 3.397.073 kasus. Oleh karena itu pentingnya upaya pencegahan agar terhindar dari virus COVID-19. Salah satunya dengan mengonsumsi makanan tinggi antioksidan. Beberapa buah yang tinggi antioksidan adalah buah belimbing wuluh dan buah mahkota dewa. Flavonoid merupakan salah satu jenis antioksidan yang terdapat pada buah belimbing wuluh dan buah mahkota dewa yang berfungsi menghambat pembentukan Reactive Oxygen Species (ROS) dengan menghambat enzim dalam pembentukan ROS dan meningkatkan regulasi serta proteksi dari antioksidan sehingga dapat mencegah berbagai dampak negatifnya seperti penyakit degenerative dan penurunan imunitas sehingga dapat mencegah dari terpaparnya virus COVID-19. Tujuan penelitian ini yaitu untuk mengetahui kadar flavonoid pada kombinasi ekstrak buah belimbing wuluh dan buah mahkota dewa. Metode yang digunakan yaitu metode spektrofotometri UV-VIS. Hasil penelitian ini yaitu didapatkan kadar flavonoid buah belimbing wuluh sebesar 2.32 mg/g, ekstrak buah mahkota dewa sebesar 4.83 mg/g dan kombinasi dari keduanya sebesar 4.77 mg/g. Dari hasil tersebut dapat disimpulkan bahwa ekstrak buah mahkota dewa memiliki kadar flavonoid tertinggi yaitu 4.83 mg/g.

AKTIVITAS FISIK DAN AKTIVASI RUMAH SINGGAH MENINGKATKAN KUALITAS HIDUP PASIEN LUPUS Nurudhin, Arief; Werdiningsih, Yulyani; Prabowo, Nurhasan Agung; Sunarso, Indrayana
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 4 No. 6 (2023): Volume 4 Nomor 6 Tahun 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v4i6.23378

Penyakit Lupus Eritematosus Sistemik (LES) merupakan suatu penyakit autoimun yang bersifat kronis dan menyebabkan nyeri pada semua ODAPUS (Orang dengan Lupus). Intervensi psikososial bertujuan untuk mengurangi rasa sakit serta meningkatkan kualitas hidup para ODAPUS. Nyeri dipengarui olehberbagai faktro salah satunya adalah faktor psikologis. Hasil analisis situasi menunjukkan bahwa nyeri menjadi masalah utama yang sering dialami oleh ODAPUS, meskipun mereka sudah rutin minum obat. Oleh karena itu, diperlukan pendekatan lain untuk mengurangi nyeri ini. Pengabdian kepada masyarakat ini bertujuan untuk meningkakan kualitas hidup pasien lupus melalui pendekatan edukasi yang berbasis komunitas.Metode pelaksanaan pengabdian ini menggunakan ceramah, diskusi, Outbond dan perbaikan rumah singgahpada ODAPUS yang merupakan anggota Yayasan Tittari. Kegiatan pengabdian dilaksanakan di Rumah Singgah Yayasan Tittari dan juga Area Danau UNS. Materi yang diangkat dalam pengabdian ini mencakup pengetahuan tentang nyeri bagi ODAPUS, metode sederhana untuk mengurangi tingkat nyeri, serta pentingnya memahami peran depresi, stres, dan ansietas dalam menyebabkan nyeri. Serta Perbaikan rumah singgah yang mengalami kerusakan selama pandemi COVID 19. Diharapkan melalui pendekatan eduksi dan perbaikan sarana rumah singgah dapat memperbaiki kualitas hidup pasien Lupus.Pemateri pada kegiatan ini adalah seorang dokter ahli nyeri rematologi. Jumlah peserta ODAPUS yang mengikuti kegiatan ini berjumlah 70 orang. Evaluasi hasil kegiatan dilakukan dengan membandingkan skor Lupus QOL Sebelum dan dalam rentang 2 bulan sesudah kegiatan. Kuisioner diedarkan secara online melaui GForm. Hasil mengabdian didapatkan adanya peningkatan Skor LupusQoL dalam beberbagai domain, serta signifikan secara statistik. .Hal ini menunjukkan adanya edukasi berbasis kominitas dan perbaikan sarana rumah singgah memperbaiki kualitas hidup ODAPUS yang terlibat kegiatan tersebut.

Beetroot (Beta vulgaris L.) reduces cholesterol and triglyceride in dyslipidemic male rats sprague–dawley model Rohman, Yulia; Nurudhin, Arief; Wardhani, Lusi Oka
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 12, No 2 (2024): June
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.12.2.80-87

Background: High-fat diets habit can lead to metabolic disorders, such as dyslipidemia which a significant contributor for cardiovascular diseases. Dyslipidemia occurs as a result of metabolically interrelated abnormalities of plasma lipids and lipoproteins, including low level of high-density lipoprotein cholesterol, and increasing of low density lipoprotein cholesterol, total cholesterol, and triglyceride. In order to enhance anti-lipid treatment, nutritional therapy containing bioactive compounds are investigated extensively, including those found in beetroot which shown potential in preventing and treating metabolic disorders.Objective: This study evaluated the effect of beetroot extract and beetroot juice on cholesterol and triglyceride levels as a dyslipidemia treatment, in comparison to simvastatin. Ethanol extract can attract flavonoids and betalain, but the extraction process can degrade fiber. Meanwhile, juice still contains quite a lot of fiber.Materials and Methods: Male Sprague Dawley rats were divided into seven groups and fed different diets for 56 days. The groups were: normal control (K0), negative control-HFD (KN), positive control-HFD + simvastatin (KP), single-dose treatment with BE (P1) or BJ (P2), and combination treatment with BE or BJ + simvastatin (P3 and P4), each intervention was given for 28 days. After blood drawn, cholesterol total and triglyceride serum were examined and analyzed.Results: Administration of beetroot extract and juice in single dose or combination with simvastatin gave a significant decrease in cholesterol and triglyceride levels compared to before the intervention. The average reduction levels of cholesterol in P1, P2, P3, and P4 were 54.81, 56.31, 94.19 and 69.11 respectively. Whereas the average decreasing level of triglyceride were 43.28, 30.78, 54.28 and 46.37 in P1, P2, P3 and P4 groups. Combination treatment with simvastatin gave more reduction level compared with single dose beetroot extract or beetroot juice. The most effective reduction was in the beet extract combination with simvastatin group were -94.19±4.08 mg/dL (cholesterol) and -54.28±6.93 mg/dL (triglyceride).Conclusion: Both beetroot extract and juice, as single or combined with simvastatin, were able to decrease cholesterol and triglyceride levels, these indicated their potential for prevention and therapeutic in dyslipidemia. Further research is needed to investigate its mechanisms and establish optimal dosages for human consumption.

Umbilical cord mesenchymal stem cell-derived secretome as a potential treatment for systemic lupus erythematosus: A double-blind randomized controlled trial Nurudhin, Arief; Werdiningsih, Yulyani; Sunarso, Indrayana; Marwanta, Sri; Damayani, Aritantri; Prabowo, Nurhasan A.; Affandi, Andri; Gazali, Itqan; Safitri, Ayu SI.; Sidarta, Brigitte RA.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1799

Umbilical cord mesenchymal stem cell-derived (UCMSC-derived) secretome is anti-apoptotic, anti-inflammatory, antifibrotic, angiogenic, and tissue-regenerating. Thus, it may treat systemic lupus erythematosus (SLE). The aim of this study was to investigate the impact of the UCMSC-derived secretome on SLE patients' disease activity, using Mexican systemic lupus erythematosus disease activity index (MEX-SLEDAI) score, complement (C3 and C4) levels, tumor necrosis factor-alpha (TNF-α), anti-double-stranded DNA (anti-dsDNA), and interleukin-6 (IL-6) levels. This double-blind randomized controlled trial investigated the efficacy and safety of UCMSC-derived secretome in SLE patients with moderate disease activity. A total of 29 female patients were randomized into two groups to receive weekly 1.5 cc intramuscular injections of UCMSC-derived secretome or placebo (0.9% NaCl) for six weeks. Disease activity was assessed using the MEX-SLEDAI score, C3 and C4 levels, pro-inflammatory cytokines (IL-6 and TNF-α), and anti-dsDNA antibodies at baseline, Day 22, and Day 43. Results showed a significant reduction in MEX-SLEDAI scores in the secretome group compared to the placebo group (p<0.05). Complement C3 levels significantly increased in the secretome group on Day 43, indicating improved immune homeostasis, while C4 levels did not show significant differences between groups. IL-6 and TNF-α levels showed decreasing trends in the secretome group. Anti-dsDNA levels exhibited a decreasing trend in the secretome group, though not statistically significant. Importantly, no severe adverse events were observed, underscoring the safety of the intervention. UCMSC-derived secretome demonstrated immunomodulatory and anti-inflammatory effects, reducing disease activity in SLE patients. These findings suggest its potential as a safe and effective adjunct therapy for SLE, although further studies with larger sample sizes and extended follow-up periods are needed to validate these results.

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