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All Journal Indian Journal of Forensic Medicine & Toxicology Journal of Global Pharma Technology
Ahmed Hamad Saleh
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Medicine & Pharmacology Public Health

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Induced Hyperlipidemia in Adult Male Rats and Treated by using Rosmarinus officinalis Aqueous Extract Marwa Karim Taha; Mohammed Salman Dalas; Ahmed Hamad Saleh
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16750

Abstract

The current work was goaled to revealed anti-hyperlipidemia activity of R. officinalis extract. This workutilized 20 male rats that divided to negative group; positive group was given drinking water containing0.5% H2O2 and (1%) cholesterol for 60 days. Third group: hyperlipidemia rats were treated with (50mg/kg/daily) extract. Fourth group: hyperlipidemia rats were treated with (100mg/kg/daily) extract. Theoutcomes revealed significant (P < 0.05) rise in cholesterol and triglyceride and reduce the HDL in positivegroup compare with negative group. Malonedialdehyied (MDA) was increased with reduce in glutathione(GSH) compare with negative group. Otherwise, diameters of aorta artery show significant (P < 0.05) risecompare with negative group. R. officinalis aqueous extract when used in treatment, the outcomes exhibitedimprovement in lipid profile, MDA, GSH and diameters of aorta artery compare with negative group. It wasconcluded that R. officinalis extract possess anti-hyperlipidemia activity.
Potential Role of Titanium Dioxide (TiO2) Nanoparticles against the Toxicity of Leishmania Tropica in Adult Albino Male Rats Ahmed Hamad Saleh
Journal of Global Pharma Technology Volume 11 Issue 03
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The present study was designed to show the role of green Tio2 nanoparticles against toxicity of Leishmania tropica. The present study used 15 adult albino male rats that divided randomly to following groups (each group consist 5 rats); control group received ad libidium, second group infected with Leishmania tropic, third group treated with 50ug/kg green Tio2 nanoparticles. Oxidative stress and antioxidant parameters in positive group injected show significant increased (P < 0.05) in levels of MDA (malonedialdehyied) and significant decreased (P < 0.05) in levels of glutathione (GSH) and catalase compared with control group. While, after used green Tio2 nanoparticles, the results showed non-significant changes (P < 0.05) in MDA, GSH and catalase levels showed non-significant changes (P < 0.05) compared with control group. Histological study of skin in positive group show severs lymphocytes infiltration between collagen fibers in dermis layer with oedema. On other hand, skin in treated group show  epidermis layers normal with dermis appear normal with normal distributed of collagen fibers and hair follicles. It was concluded that green Tio2 nanoparticles has been potential role against toxicity of Leishmania tropica in male rats.Keywords: Tio2 nanoparticles; Leishmania tropica; Oxidative stress; Antioxidant factors.
Co-Authors Marwa Karim Taha Mohammed Salman Dalas