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All Journal Indian Journal of Forensic Medicine & Toxicology Journal of Global Pharma Technology
Jawad Kadhim Faris
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Medicine & Pharmacology Public Health

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Biochemical and Histopathological effects of Acetaminophen and Protective Effects of Naringin on Liver Rats Aryaf Mahmood Sabea; Ahlam J. H. AlKhamas; Bashar Sabah Sahib; Jawad Kadhim Faris
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16801

Abstract

This study was conducted to find out liver protective activity of naringin (NRG) 40-80 mg/kg body weight(b.w.) against acetaminophen (ACN) 2g/kg induced liver damage in rats. Thirty two male rats were dividedinto four groups : group1: negative control, (1 ml/kg Saline orally) group II: positive control ACN (2g/kg), orally as single dose at first day, group III: ACN (2g/kg), orally as single dose at first day , plus NRG(40 mg//kg) orally for (8) consecutive days, group IV: ACN (2g/kg), orally as single dose at first day , plusNRG (80 mg//kg) orally for (8) consecutive days. All the rats were anesthetized to collect blood then killedon the (9) day of the experiment to take the liver samples. ACN induced liver damage was proved by asignificant (P<0.01) reduction in the body weight , total protein (TP) , albumin (AB) , superoxide dismutase(SOD) and catalase (CAT) enzymes and a significant (P<0.01) increased in liver weight, serum aspartatetransaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin (TB), directbilirubin (DB) , malondialdehyde enzyme (MAD) and histopathological changes. Protective liver toxicityeffect and oxidative damage caused by ACN significantly (P<0.01) increasing in body weight, TP, AB ,SODand CAT and significantly (P<0.01) decreasing in liver weight , AST, ALT, ALP, TB, DB and MAD andimproving tissue morphology by a meliorative in NRG 40 , 80 mg/kg b.w. These results confirm that NRGantioxidant effects can protect ACN induced hepatic toxicity in rats.
Assessment the Effects of Ciprofloxacin and Gentamicin Alone or in Combination to Induce Hepatic Toxicity in Rats Jawad Kadhim Faris
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The aim of this study was to research the comparative effects of ciprofloxacin (CP)  and gentamicin (GT) alone or in combination on the deleterious effects on liver function  and histopathological architecture in rats for  (10) days administration. Doses of 100 mg/kg were used for each of  CP and GT ,and each of both drugs 50mg/kg were combined to estimate the synergistic effect .Thirty two  rats were divided into four groups , group I :control , (1 ml/kg saline orally) group 2: CP  (100 mg/kg orally)  for (10) consecutive days , group 3:  GT  (100 mg//kg) intraperitoneally (i/p)  for (10) consecutive days, group 4: CP  (50 mg/kg orally) plus GT  (50 mg//kg)  i/p  for (10) consecutive days . Blood and liver collected for biochemical and histopathological examination of the liver. The degree of liver injury was determined by measuring biochemical markers, the serum activity of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Malondialdehyde (MDA) levels, as measures of oxidative stress. The results of this study showed that in the serum of the rats in the test groups were found to be significantly higher (p < 0.01) than control group; this effect was found to vary among the groups. These findings are indicative that combination of CP + GT more injury to hepatocytes than GT and CP respectively .The synergistic effects of combination of CP + GT showed the higher levels of liver enzyme and sever liver injury.  Keywords:  Gentamicin, Ciprofloxacin, Combination Hepatotoxicity.
Co-Authors Ahlam J. H. AlKhamas Aryaf Mahmood Sabea Bashar Sabah Sahib