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All Journal Indian Journal of Forensic Medicine & Toxicology
K.M.K. Mastan
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Public Health

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Serum Uric Acid Level in Oral Cancer Patients -Original Study G. Florence Sangeetha; K.M.K. Mastan; N. Aravindha Babu; S. Leena Sankari; Jayasri Krupa; T. Gopala Krishnan
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16865

Abstract

Background Uric acid is a result of the metabolic breakdown of purine digestion. Serum uricacid ensures against carcinogenesis by means of its cell reinforcement properties and forestalls thedevelopment of oxygen extremists. High blood groupings of uric acid can prompt gout and are relatedwith diabetes and development of kidney stones. Serum uric acid fixation mirror the harmony betweenuric acid combination and discharge. Studies have indicated that high uric acid is a danger factorfor hypertension, diabetes and Cardio Vascular illness.Squamous cell carcinoma is characterized asthreatening epithelial neoplasm showing squamous separation as described by the development of keratinor the bury cell spans. It also includestheinitialpresenceofaprecancerous lesion.Moreover,specificmedicalconditionscancontributetotheoral potentially malignant disordersprevalenceOral squamous cellcarcinoma is the most well-known neoplasm speaking to over 80% of all oral malignancy cases. Serum uricacid has been proposed to be related with the danger of malignant growth and it was seen that raised degreesof serum uric acid was related with an expanded disease frequency contrasted with typical qualities.Aim and Objectives : The aim of this study is to evaluate the serum uric acid level in oral cancer patients,to find out the association between low serum uric acid level and risk of squamous cell carcinoma and tocompare the serum uric acid levels in oral cancer patients with normal individuals.Materials and Methods : This is a hospital based study to find out the uric acid level in oral cancer patients.The participants were selected from the out patients, Department of Oral Pathology and Microbiology. Thestudy included a total numbe of 28 persons. Out of the 28 persons 15 oral cancer patients were selected forthe experimental group. The remaining 13 subjects were in the normal group.Results : In this study, mean uric acid level in this stroke population with CAD is 6.37 mgs/dl and in thosewithout CAD is 5.00 mgs/dl and thus establishes a statistically significant relationship (‘p’0.0004). Whenmales and females are considered, males have a significant association with a ‘p’ value of 0.0003. The buccalmucosa of the oral cavity was the most common involved site followed by the vestibule.Conclusion : The studies showed that serum uric acid level was significantly lower in oral cancer patientscompared to the control group. Uric acid may prevent the formation of oxygen radicals and there by protectagainst carcinogenesis. In human’s uric acid is the most abundant antioxidant and is an important intracellular free radical scavenger. Early detection of oral cancer and Habit should be controlled to reducemortality rates and help to provide successful cancer treatment.
Evaluation of Oral Manifestations of Patients with Parkinson’s Disease–An Observational Study T. Gopalakrishnan; K.M.K. Mastan; P.E. Chandra Mouli; Naga Leela Guntuku; Priyadharshini A; G. Florence Sangeetha
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16908

Abstract

Background: Parkinson’s disease is the second most common neurodegenerative disorder which affectsaround four million people globally.Many of the signs of Parkinson’s disease are found in the head andneck. The typical “masklike” facial appearance with infrequent blinking and lack of expression is causedby bradykinesis.. Abnormalities in oral behaviour, such as purposeless chewing, grinding, and suckingmovements, are also well recognized in patients with Parkinson’s disease.Aim and Objectives: The aim of this study is to assess the overall oral health status of the patients withParkinson’s disease and to analyze the impact of Parkinson’s disease on the oral cavity of the individualssurviving with the disease.Materials and Methods: The study sample included 50 Parkinson’s disease patients. The patients of all agegroups and both genders were included.Results: Out of fifty patients. majority of the patient s were above 60 yrs. 6% of the patients reported withPositive family history of Parkinson’s diseases.14% of the patients had gross facial asymmetry, 68% of thepatients showed dryness of mouth.8% of the patients suffered loss of taste.14% of the patients showed hypersalivation. 54% of the patients showed gingivitis. And 76% of the patients were found having periodontitis.Conclusion: Treatment for oral and dental problems of Parkinson’s disease affected patients is mandatory.Treatment can be done by supplementing artificial saliva for dryness of mouth, dental fillings for dentalcaries, periodic scaling for periodontal problems, oral rehabilitation measures and regular dental check up
Co-Authors G. Florence Sangeetha Jayasri Krupa N. Aravindha Babu Naga Leela Guntuku P.E. Chandra Mouli Priyadharshini A S. Leena Sankari T. Gopala Krishnan T. Gopalakrishnan