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All Journal Indian Journal of Forensic Medicine & Toxicology
Dakhel Ghani Omran
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Public Health

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Effect of Nanoparticles and Ionization Radiation on Same Oxidant and Antioxidant Enzymes Rafal Dawood Ali; Baydaa T. Sih; Dakhel Ghani Omran
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.17242

Abstract

Ionizing radiation effect on atoms and molecules of living organisms by formation of free radicalsbecause it has high energy radiation which causes gain or loss one electron or more. In last year’sthere are a biggest interest for using nanoparticles in medicine as a drag delivers or cancer treatments, as its will knew. The present research was focused to evaluate the effects of X- ray and nanoparticles(alone or together) on level of Malondiahyed ( MDA ) , it is the final product of oxidative reactions ,and, on the other hand , alleviate these effects by addition of vitamin – E ( as anti- oxidant ) in bloodsamples in-vitro. Results which were yield from this research indicated that level of MDA had beensignificantly increased when blood samples exposed to X- rays but its values were significantly droppedin the presence of nanoparticles of titanium dioxide (TiO2) in a comparison with those non- treatedblood samples ( control samples ) . It was well found that levels of MDA were markedly decrease inthe samples treated with V- E after exposure them with both X-ray and nanoparticles . From thoseobservations , it appear that exposure of living tissues to X-rays and nanoparticles causing productionof free radicles ( oxidative stress ) and these adverse effects can be limited and ameliorated by treatmentwith antioxidant vitamins .
Tissue Factor and Tissue Factor Pathway Inhibitor in Men and Women Affected with Hypertension Noor Ghaleb Abdul Kareem; Dakhel Ghani Omran
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.16220

Abstract

Hypertension is one of the most common chronic diseases characterized with continuous elevation of bloodpressure. The present study involved tested 45 hypertensive men and 45 hypertensive women. Sixty (60)apparently healthy subjects (30 men and 30 women) were also included to serve as a control group. All menand women were subdivided into three groups according to their ages (41-50, 51-60, 61-70 years old).Results yield from present study indicated a significant decrease (p<0.05) in the levels of testosterone andestradiol in first age group of hypertensive men and women respectively and there were nonsignificantdifferences (p>0.05) in second and third age groups of patients compared to healthy groups.A significant progressive increase (p<0.05) in the levels of tissue factor (TF) in all groups of hypertensivemen and women compared to healthy groups. In contrast, values of tissue factor pathway inhibitor (TFPI)confirmed a significant lowering (p<0.05) in all age groups of hypertensive men and women when comparedwith those healthy subjects. In conclusion, data obtained from this study can be attributed to damage ofvascular system resulted from continuous increase blood pressure, drop of sexual hormones, and aging
Effects of Contraception Pills and Hormone Replacement Therapy on Tissue Plasminogen Activator -1 and Plasminogen Activator Inhibitor-1 in Per and Postmenopausal Women Hind Chassab Karam; Dakhel Ghani Omran
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.16248

Abstract

Contraception is a program employed to avoid pregnancy during premenopausal period where as hormonereplacement therapy (HRT) is a medical option to ameliorate menopausal complications. The present studywas designed to evaluate the effects of contraceptions and HRT on estradiol hormone ,tissue plasminogenactivator-1 (TPA-1),and plasminogen activator in hibitor-1(PAI-1).One hundred (120) women were recruited ;30 women with contraception; 30 women with HRT ,and60women contraception ; with HRT , and 60 women as a control group. All ages of women were rangedbetween 31-70 years old and subdivided into four groups(31-40,41-50, 51-60, 61-70 years old ).Data obtained from this study indicated a significant elevation (p<0.05) in the levels of estradiol hormone inall tested groups of women compared to control women (without contraception and HRT).It was establisheda significant drop (p<0.05) in the concentration of TPA-1 in women taking contraception and those intakeHRT in a comparison with control groups. About levels of PAI-1,they were significantly higher (p<0.05)in both women with contraception and HRT than of control women .From these observations the availableconclusion may be administration of contraception and HRT influence fibrinolytic system and increaseincidence of thrombotic events .
Co-Authors Baydaa T. Sih Hind Chassab Karam Noor Ghaleb Abdul Kareem Rafal Dawood Ali