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All Journal The International Journal of Medical Science and Health Research The Indonesian Journal of General Medicine
Pretty Grace Zalukhu
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Use Of Glutathione As An Additional Supplement For The Treatment Of Fatty Liver Disease : A Systematic Review Pretty Grace Zalukhu; Widjaja Lukito
The Indonesian Journal of General Medicine Vol. 7 No. 1 (2024): The Indonesian Journal of General Medicine
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/jkw23v04

Abstract

Introduction : The liver normally contains fat tissue, but if it exceeds 5% of the liver weight, this condition is called fatty liver disease. Fatty liver disease is divided into two major groups, namely : Alcoholic Fatty Liver Disease (AFLD) and Non-Alcoholic Fatty Liver Disease (NAFLD). Fatty liver disease can potentially progress to liver cirrhosis, and this can be prevented by antioxidants, through their anti-inflammatory actions. Glutathione is a potent antioxidant, and naturally produced in our body, with the highest level in the liver, which is the main organ in the detoxification process. This study aimed to systematically review the importance of Glutathione as an adjunct supplement for the treatment of fatty liver disease, which is one of antioxidants, can help with fatty liver problems. Methods : This study applied a Systematic Review approach, that included published articles with Randomized Controlled Trials (RCTs). We searched these articles in two electronic databases, namely Google Scholar and PubMed. Based on the search, 1.141 cases of fatty liver were found and the author determined 2 (two) relevant literature/studies that focus on this research. Results : Based on 2 studies with a total of 208 patients and divided into 2 groups, namely the intervention group and the control group, it was found that the group that was intervened with glutathione supplementation for at least 3 months experienced a decrease in CAP, ALT, and IMT values. Especially if coupled with MHD/improved healthy lifestyle, the recovery process of fatty liver conditions can take place faster. Conclusions : Glutathione as an antioxidant and acts as a hepatoprotector, demonstrated the ability to potentially hold the progression of NAFLD, and improve liver function. The presence of MHD/improve healthy lifestyle synergized the efficacy of Glutathione against the progression of NAFLD.
The Role Of Omega 3 Supplementation In Repeated Transient Ischemic Attack : A Case Report Pretty Grace Zalukhu; Corry Ida Hinaya Zalukhu
The International Journal of Medical Science and Health Research Vol. 7 No. 1 (2024): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/3avvkm83

Abstract

Introduction: According to a 2021 worldwide analysis, 1 in 4 adults will suffer a stroke in their lifetime. Risk factors include hypertension, diabetes mellitus, dyslipidemia, and atrial fibrillation. Lifestyle is a critical factor in stroke prevention. More importantly, dietary habits were shown to be the most relevant. To reduce the risk of ischemic stroke, nutritional approaches have historically focused on high-fiber diets with low in sodium, saturated fat, and cholesterol. It is well known that n-3 PUFAs reduce the risk of cardiovascular diseases. Case Report: A 65-years old woman present with headache and myalgia. She was grade I obese with a body weight of 69 kg. The patient has history of transient ischemic attack (TIA) twice within a year. There is a history of type 1 diabetes mellitus thus taking insulin for a year and hypertension for 2 years. On examination, the blood pressure was 170/90 mmHg. Both of her foot were swollen. Laboratory test results were normal. History of medication includes Amlodipine, Candesartan, Furosemide, dan Glargine. Omega 3 supplementation was planned to reduce inflammation and risk of future episodes of stroke. Conclusion: Omega-3 PUFA have various pharmacological activities, such as anti-inflammatory, anti-thrombosis, anti-atherosclerosis, reduce blood lipid levels and significantly improve endothelial dysfunction. Omega-3 is also beneficial in obesity and diabetics, which are risk factors of stroke or TIA.
Co-Authors Corry Ida Hinaya Zalukhu Widjaja Lukito