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All Journal Jurnal Fisika Unand Jurnal Ilmu Fisika
Siyami, Rizka Mutik
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Astronomy Earth & Planetary Sciences Electrical & Electronics Engineering Energy Materials Science & Nanotechnology Physics

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The Accuracy of TIAC Calculated Using SPECT/CT Imaging Data at 36- and 100-Hours Post Injection and Prior Information in 177Lu-DOTATATE Siyami, Rizka Mutik; Sri Oktamuliani; M. Dlorifun Naqiyyun; Intan Apriliani Syaridatul Mu'minah
Jurnal Ilmu Fisika Vol 16 No 1 (2024): March 2024
Publisher : Jurusan Fisika FMIPA Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jif.16.1.55-62.2024

Abstract

In internal radionuclide therapy, there is a growing demand for streamlined methods that alleviate the measurement burden on patients and reduce the associated costs of individual dosimetry. This study assessed the precision of the Two Time Point Dosimetry (2TPD) model, a data-efficient approach, compared to the well-established All Time Point Dosimetry (ATPD) model. The investigation involved the analysis of time-activity data collected from the kidneys of seven patients who were administered 177Lu-DOTATATE and underwent SPECT/CT imaging (PMID 3344306). Data points were specifically gathered at the 36-hour and 100-hour post-injection marks. Employing prior information, a monoexponential function was applied to fit the biokinetic data. Consequently, two crucial metrics, TIAC ATPD and TIAC 2TPD, were computed for ATPD and 2TPD, respectively. To provide a benchmark, the TIAC determined via the Hänscheid method was also incorporated for comparison. The comparative analysis revealed that the percentage error between the population ATPD model and the 2TPD model was (3.97 ± 7.85)%, and for the Hänscheid model, it was (1.8 ± 7.9)%. These findings affirm that the accuracy of TIAC values derived from the 2TPD approach, leveraging prior-information fitting, is reasonably satisfactory.
The Accuracy of TIAC Calculated Using SPECT/CT Imaging Data at 36- and 100-Hours Post Injection and Prior Information in 177Lu-DOTATATE Siyami, Rizka Mutik; Sri Oktamuliani; M. Dlorifun Naqiyyun; Intan Apriliani Syaridatul Mu'minah
Jurnal Ilmu Fisika Vol 16 No 1 (2024): March 2024
Publisher : Jurusan Fisika FMIPA Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jif.16.1.55-62.2024

Abstract

In internal radionuclide therapy, there is a growing demand for streamlined methods that alleviate the measurement burden on patients and reduce the associated costs of individual dosimetry. This study assessed the precision of the Two Time Point Dosimetry (2TPD) model, a data-efficient approach, compared to the well-established All Time Point Dosimetry (ATPD) model. The investigation involved the analysis of time-activity data collected from the kidneys of seven patients who were administered 177Lu-DOTATATE and underwent SPECT/CT imaging (PMID 3344306). Data points were specifically gathered at the 36-hour and 100-hour post-injection marks. Employing prior information, a monoexponential function was applied to fit the biokinetic data. Consequently, two crucial metrics, TIAC ATPD and TIAC 2TPD, were computed for ATPD and 2TPD, respectively. To provide a benchmark, the TIAC determined via the Hänscheid method was also incorporated for comparison. The comparative analysis revealed that the percentage error between the population ATPD model and the 2TPD model was (3.97 ± 7.85)%, and for the Hänscheid model, it was (1.8 ± 7.9)%. These findings affirm that the accuracy of TIAC values derived from the 2TPD approach, leveraging prior-information fitting, is reasonably satisfactory.
Penentuan Konsentrasi Radionuklida (226Ra, 210Pb, 210Po dan 40K) pada Tembakau Rokok yang Beredar di Kota Padang Menggunakan Spektrometer Gamma dan RAD7 Siyami, Rizka Mutik; Milvita, Dian; Kusdiana, Kusdiana
Jurnal Fisika Unand Vol 10 No 3 (2021)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jfu.10.3.344-350.2021

Abstract

Telah dilakukan pengukuran konsentrasi radionuklida (226Ra, 210Pb, 210Po dan 40K) pada tembakau rokok di Kota Padang menggunakan spektrometer gamma dan RAD7.  Penelitian ini bertujuan untuk menentukan konsentrasi radionuklida pada tembakau rokok dan mengestimasi dosis efektif tahunan yang diterima perokok.  Pengukuran konsentrasi radionuklida dilakukan pada 3 merek tembakau rokok, diawali dengan preparasi sampel, kalibrasi spektrometer gamma dan RAD7, serta pengukuran konsentrasi radionuklida.  Hasil penelitian menunjukkan bahwa konsentrasi 226Ra terukur pada semua sampel dengan nilai tertinggi ialah (2,29 ± 0,56) Bq/kg.  Konsentrasi 210Po terukur pada semua sampel dengan nilai tertinggi yaitu 1,61 Bq/kg.  Konsentrasi 40K terukur di semua sampel tembakau rokok dengan nilai tertinggi ialah (1.069,05 ± 101,97) Bq/kg. Konsentrasi radionuklida 210Pb tidak terukur pada semua sampel.  Estimasi dosis efektif tahunan yang diterima perokok paling tinggi berasal dari radionuklida 226Ra yaitu 36,1 μSv/tahun, estimasi dosis efektif tahunan total ialah 88,5 μSv/tahun.  Nilai konsentrasi radionuklida yang terukur melebihi batas konsentrasi radionuklida oleh IAEA TE 1788, sedangkan nilai estimasi dosis efektif tahunan yang didapatkan tidak melebihi batas dosis yang ditetapkan UNSCEAR 2010.
Co-Authors Dian Milvita Intan Apriliani Syaridatul Mu'minah Kusdiana Kusdiana, Kusdiana M. Dlorifun Naqiyyun Sri Oktamuliani