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All Journal Jurnal Ners Journal of International Surgery and Clinical Medicine
Mardhiyah, Farah
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Health Professions Medicine & Pharmacology Nursing

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Understanding Trigeminal Neuralgia: A Comprehensive Review of Symtoms, Diagnosis, and Management Valentino, Andrea; Mardhiyah, Farah; Maspian Tjili, Tondi; Hadisi, Anthar; Aji Prihartomo, Gatot; Prastya Pardede, Jeremia; Wirdayanto, Ade
Journal of International Surgery and Clinical Medicine Vol. 4 No. 2 (2024): (Available online: 1 December 2024)
Publisher : Surgical Residency Program Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jiscm.v4i2.62

Abstract

Trigeminal neuralgia (tic douloureux) is a rare and debilitating facial pain condition affecting one or more branches of the trigeminal nerve. It is frequently misdiagnosed as a dental issue or temporomandibular disorder due to overlapping symptoms, delaying appropriate treatment. Diagnosis is primarily clinical, often requiring the expertise of a neurologist to distinguish it from other causes of facial pain. Imaging studies such as MRI or CT scans are not diagnostic but play a crucial role in ruling out secondary causes and identifying pathological changes in the affected nerve root. Although not life-threatening, trigeminal neuralgia significantly impacts the quality of life, causing severe, recurrent pain episodes that can be challenging to manage. Timely and accurate diagnosis, along with the implementation of effective therapeutic strategies, is essential to alleviate symptoms and improve patient outcomes. This review highlights the clinical presentation, diagnostic approach, and current treatment modalities for trigeminal neuralgia, emphasizing the importance of a multidisciplinary approach to care.
Serum Prolactine Levels and Prolactine Receptor Expression in Premenopausal Breast Cancer: A Potential Predictive Biomarker? Tripriadi, Effif Syofra; Maulanisa, Sinta Chaira; Lipoeto, Nur Indrawati; Yanwirasti, Yanwirasti; Oenzil, Fadil; Harahap, Wirsma Arif; Utami, Tania Nugrah; Mardhiyah, Farah
Jurnal Ners Vol. 10 No. 1 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.52299

Abstract

Introduction: Premenopausal breast cancer (PBC) is often more aggressive than postmenopausal cases, with prolactin playing a key role in tumor development. This study examines the relationship between serum prolactin levels, prolactin receptor (PRLR) expression, and clinicopathological features in PBC patients. Methods: This cross-sectional study was conducted from 2021 - 2022 at multiple hospitals in Pekanbaru, Indonesia. Thirty-five PBC patients and 35 healthy controls were included. Serum prolactin levels were measured using ELISA, and PRLR expression was assessed via IHC. Statistical analysis was performed using independent t-tests and correlation analysis (p < 0.05). Results: PBC patients had higher prolactin levels (51.96±80.40 ng/mL) than controls (20.83±15.74 ng/mL, p = 0.031). PRLR expression was detected in over 90% of tumors, with a significant correlation between prolactin levels and cancer stage (p = 0.035). Discussion: These findings suggest prolactin contributes to PBC progression, with higher levels linked to advanced stages, possibly through JAK2/STAT5 signaling. Conclusion: Serum prolactin levels and PRLR expression are associated with cancer stage, supporting their potential as biomarkers for early detection and disease progression. Further studies are needed for validation.
Co-Authors Aji Prihartomo, Gatot Effif Syofra Tripriadi, Effif Syofra Fadil Oenzil Hadisi, Anthar Maspian Tjili, Tondi Maulanisa, Sinta C. Nur Indrawati Lipoeto Prastya Pardede, Jeremia Utami, Tania Nugrah Valentino, Andrea Wirdayanto, Ade Wirsma Arif Harahap Yanwirasti Yanwirasti