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Concordance and Acceptability of HPV DNA Genotyping Test by Patient’s Self-Sampling Against Clinician Sampling Indarti, Junita; Syaharutsa, Danny Maesadatu; Surya, Ilham Utama; Alda, Kristian
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 2 April 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i2.2402

Abstract

Objectives: To determine the effectiveness of this alternative method, especially during the COVID-19 pandemic and considering Indonesia’s cultural context. Methods: This study utilized a cross-sectional design, and involved patients at the Gynecology and Colposcopy Clinic of Dr. Cipto Mangunkusumo General Hospital. The estimated sample size was 48, determined using a diagnostic test formula. The sample population consisted of female patients with positive VIA or abnormal Pap smear results. Each patient underwent HPV DNA self-sampling and clinician sampling tests using the GenoFlow HPV Array technique and continued with colposcopy. All patients were also administered a questionnaire consisting of eight questions about their perspective on the self-sampling HPV DNA test. The data analysis employed a 2 × 2 table using SPSS version 20, and Cohen’s kappa coefficient was calculated to measure the agreement between the sampling results of patients’ and Clinicians’. Results: Among the examinations conducted by clinicians, there were 33 patients with positive HPV results, whereas through self-sampling, there were 28 patients with positive HPV (p=0.00). High risk HPV was the most commonly observed, with HPV type 16 appearing the most (15%). Based on these data, the self-sampling sensitivity, specificity, positive predictive value, and negative predictive value were 85%, 100%, 100%, and 75%, respectively, with a concordance rate of 89.6%. The Cohen’s Kappa coefficient between samples taken by the clinician and self-sampling resulted in K=0.778, which is considered a good agreement (K=0.61-0.80). All patients concluded that the procedure was easy (100%), and the majority (60.5%) expressed a preference for the self-sampling method. Conclusion: There is a good agreement between the results of self-sampling and clinician sampling for detecting HPV DNA, with patients positively accepting the self-sampling method, indicating its potential as an effective cervical cancer screening method. Keywords: Cervical Cancer Screening, Clinician Sampling, Human Papillomavirus, Self-Sampling.
Risk Factors of Intrauterine Fetal Death in Cipto Mangunkusumo General Hospital, Indonesia Indarti, Junita; Mardhatillah, Syifa; Alda, Kristian; Vitasatria, Arresta; Solihin, Affan; Sumulyo, Ganot; Ikhsan, Muhammad; Agassi Antoniman, Mohammad
Jurnal Health Sains Vol. 5 No. 11 (2024): Jurnal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v5i11.1394

Abstract

Intra Uterine Fetal Death ( IUFD ) results from various disorders of the mother, fetus, and placenta. This study aimed to explore factors contributing to IUFD, knowing the risk factors will prevent this case in the future time. In 2016-2018, patients diagnosed with IUFD at 22 weeks of gestation were included. One hundred twenty-five patients with IUFD and 125 controls with alive fetuses were enrolled. Data were collected from the medical records of participants. Factors that may have contributed to IUFD were explored. Comparisons between various risk factors and outcomes of the two groups were made. P-value was statistically significant if ≤0.05. We found several factors that contribute to IUFD. Some factors like BMI, ANC provider, referred from tertiary health facility, and congenital anomaly increased the risk of IUFD by 2.86, 5.86, 6.26 and 9.45 times respectively. In contrast, some factors like a number of ANC ≥ 6 times and gestational age >36 weeks decrease the risk of IUFD. Regular and intensive ANC ≥ 6 times during pregnancy, number of pregnancy and gestational age ≥ 36 weeks significantly decreases the risk of IUFD with OR 0.12, 0.4, and 0.23 respectively. High-quality ANC to identify IUFD risk factors may lead to a significant decrease in its occurrences. Some factors like BMI, ANC provider, referred from tertiary health facility, and congenital anomaly increased the risk of IUFD, but Number of ANC≥ 6 times, number of pregnancy ≥2 and gestational age ≥36 weeks can reduce risk of IUFD.