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All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Surya, Ilham Utama
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Health Professions Medicine & Pharmacology Public Health

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Concordance and Acceptability of HPV DNA Genotyping Test by Patient’s Self-Sampling Against Clinician Sampling Indarti, Junita; Syaharutsa, Danny Maesadatu; Surya, Ilham Utama; Alda, Kristian
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 2 April 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i2.2402

Abstract

Objectives: To determine the effectiveness of this alternative method, especially during the COVID-19 pandemic and considering Indonesia’s cultural context. Methods: This study utilized a cross-sectional design, and involved patients at the Gynecology and Colposcopy Clinic of Dr. Cipto Mangunkusumo General Hospital. The estimated sample size was 48, determined using a diagnostic test formula. The sample population consisted of female patients with positive VIA or abnormal Pap smear results. Each patient underwent HPV DNA self-sampling and clinician sampling tests using the GenoFlow HPV Array technique and continued with colposcopy. All patients were also administered a questionnaire consisting of eight questions about their perspective on the self-sampling HPV DNA test. The data analysis employed a 2 × 2 table using SPSS version 20, and Cohen’s kappa coefficient was calculated to measure the agreement between the sampling results of patients’ and Clinicians’. Results: Among the examinations conducted by clinicians, there were 33 patients with positive HPV results, whereas through self-sampling, there were 28 patients with positive HPV (p=0.00). High risk HPV was the most commonly observed, with HPV type 16 appearing the most (15%). Based on these data, the self-sampling sensitivity, specificity, positive predictive value, and negative predictive value were 85%, 100%, 100%, and 75%, respectively, with a concordance rate of 89.6%. The Cohen’s Kappa coefficient between samples taken by the clinician and self-sampling resulted in K=0.778, which is considered a good agreement (K=0.61-0.80). All patients concluded that the procedure was easy (100%), and the majority (60.5%) expressed a preference for the self-sampling method. Conclusion: There is a good agreement between the results of self-sampling and clinician sampling for detecting HPV DNA, with patients positively accepting the self-sampling method, indicating its potential as an effective cervical cancer screening method. Keywords: Cervical Cancer Screening, Clinician Sampling, Human Papillomavirus, Self-Sampling.
Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Length of Cervix as Predictors of Premature Delivery during the Covid-19 Pandemic at Cipto Mangunkusumo General Hospital Djusad, Suskhan; Surya, Ilham Utama; Purnadiputra, Akbar; Pribadi, Muhamad Ichsan; Wicaksono, Muhammad Adhitya
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 1 January 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i1.1743

Abstract

Abstract Objective: The percentage of neonatal death continues to increase on a yearly basis, in which prematurity is the main cause of mortality. This study determines the descriptive outcomes between neutrophil-lymphocyte ratio (NLR), platelet lymphocyte ratio (PLT), and cervical length as predictors of preterm birth. Methods: A retrospective analytical study is conducted using medical records from Dr. Cipto Mangunkusumo National General Hospital. The subjects of this study includes pregnant women diagnosed with preterm delivery in Dr. Cipto Mangunkusumo National General Hospital from April 2020 to June 2021. Data on neutrophil-lymphocyte and platelet-lymphocyte ratios were obtained from a complete blood test during admission. Cervical length is measured using transvaginal ultrasound. The three variables are compared to the control group, which consists of pregnant women with full term delivery. Results: This study conducted a study with a total of 81 subjects with preterm delivery and 92 subjects with full term delivery. There were no significant difference in neutrophil-lymphocyte and platelet-lymphocyte ratios between preterm and a-term delivery (p=0.795 and p=0.475). Cervical length was significantly longer in preterm compared to full term delivery (24,50 vs 3,15 mm; p = 0,031). The neck cervical length of several participants was not assessed. Cervical length in preterm delivery obtained only 21 patients and data from 10 subjects from the full term group. Conclusion: The ratio of neutrophil-lymphocyte and platelet-lymphocyte cannot be used as predictors of preterm birth in all pregnant women. To reduce bias in this research, studies with prospective study design with a specified subject criteria are needed. Keywords: cervical length, neutrophil-lymphocyte ratio, platelet lymphocyte ratio, premature delivery
Co-Authors Alda, Kristian Djusad, Suskhan Junita Indarti Pribadi, Muhamad Ichsan Purnadiputra, Akbar Syaharutsa, Danny Maesadatu Wicaksono, Muhammad Adhitya