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All Journal Indonesian Journal of Urology Brawijaya Journal of Urology
Palinrungi, Muhammad Asykar
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Health Professions Medicine & Pharmacology Public Health

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Potential of Preoperative Testosterone Stimulation Therapy to Reduce Complication in Hypospadias Repair: A Systematic Review and Meta-Analysis Munawwir, Abdul; Mustamar, Fikri Akbar; Palinrungi, Muhammad Asykar; Aristo, Aristo
Brawijaya Journal of Urology Vol. 6 No. 01 (2025): Brawijaya Journal of Urology
Publisher : Department of Urology, Faculty of Medicine, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/bjurology.2025.006.01.4

Abstract

Introduction. The pre-operative hormone stimulation is recommended for hypospadias patients, especially those with small penis, to improve the results and outcomes of hypospadias repair. We conducted a systematic review and meta-analysis to evaluate the effectiveness of pre-operative testosterone stimulations before hypospadias repair. Methods. We performed a comprehensive search for relevant studies from PubMed, Medline, Cochrane, Proquest, and Embase from August 2000 until August 2023 . The phrases "hypospadias" and "testosterone treatment" were utilized. Only studies focusing on patients diagnosed with hypospadias were considered. This analysis exclusively included English-language papers, randomized control trials, cohort studies, and case-control studies. Case studies without comparable groups were excluded. Editorials, comments, and review articles were excluded from the study. We used the PRISMA guidelines for this systematic review and meta-analysis report. RevMan version 5.4.1 was used to analyze and evaluate the data. Results. A total of 832 patients undergoing urethroplasty were evaluated in 7 studies. A total of 372 patients were categorized into the intervention group, which received testosterone hormone therapy (parenteral, intramuscular, and topical). Patients who receive preoperative testosterone therapy have a 0.68 reduced risk of complications rate compared to those who did not (P = 0.03, I2 = 28%, CI: 0.68, OR: 0.48 - 0.96), reduced meatal stenosis (P = 0.04, OR: 0.66, 95% CI: 0.44 - 0.98, I2 = 28), reduced the risk of postoperative glans dehiscence (P = 0.0004, OR: 0.46, 95% CI (0.30-0.71), I2 = 57%), and reduced risk of fistula urethrocutaneous (P = 0.03, OR: 0.58, 95% CI: 0.36 - 0.94, I2 = 22%). Conclusion. Pre-operative testosterone stimulation can improve surgical outcomes. Complication rates, such as meatal stenosis, glans dehiscence, and fistula, showed a significant effect in patients who intervened with testosterone stimulation pre-hypospadias repair. Keywords: hypospadia, improve, outcome, repair, testosterone
RIGHT TESTICULAR SEMINOMA IN AN ADULT WITH BILATERAL CRYPTORCHIDISM PRESENTING AS AN ABDOMINAL MASS: A CASE REPORT AND REVIEW OF LITERATURE Azis, Abdul; Syarif; Mayidah, Maryam; Giffari Makkaraka, Moh. Anfasa; Palinrungi, Muhammad Asykar
Indonesian Journal of Urology Vol 33 No 2 (2026)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v33i2.1046

Abstract

Introduction: Testicular seminomas are relatively rare malignancies that typically present in younger males with normal testicular descent. However, in the context of bilateral cryptorchidism, the presentation and diagnostic challenges are more complex. Objective: This study aims to report a case of a patient with bilateral cryptorchidism with a seminoma originating from the undescended right testis presenting as a rapidly growing abdominal mass. Case(s) Presentation: We reported a 29-year-old man complaining of a mass in the right lower abdomen for the past four months and no palpable testicles. A whole-abdomen computed tomography image revealed an intra-abdominal mass measuring 11 x 10 x 7 cm and suspected malignancy originating from the undescended testicles. Discussion: The patient underwent a right orchidectomy and a left orchidopexy. Histopathology confirmed seminoma of the specimen with pT1N0M0 staging. The patient was discharged and later referred to the oncology department. Conclusion: This case emphasizes the importance of promptly genitourinary evaluation during a regular physical examination and closely monitoring individuals with undescended testis due to the potential for it to be a malignancy, especially in patients presenting with an abdominal mass. Keywords: Testicular seminoma, cryptorchidism, case report.
Co-Authors Abdul Azis Aristo Aristo, Aristo Giffari Makkaraka, Moh. Anfasa Mayidah, Maryam Munawwir, Abdul Mustamar, Fikri Akbar Syarif