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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences JMM (Jurnal Masyarakat Mandiri)
Putri, Agustine Hanafi
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Agriculture, Biological Sciences & Forestry Environmental Science Other

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Secretory Leukocyte Protease Inhibitor (SLPI) Decreased the Celluler Expression of NF-Kβ and IL-1β on Wound Macrophages of Rattus novergicus Post Tooth Extraction Putri, Agustine Hanafi; Komaruzzaman, Abdur Razaq; Noerpuspita, Putri; Fitriyani, Delfi; Permatasari, Nur; Widjajanto, Edi
Journal of Tropical Life Science Vol 6, No 3 (2016)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.06.03.05

Abstract

Prevalence of tooth extraction or dental surgery was 48.5% of all dental care in Indonesia. Tooth extraction carries potential health risks and side effects such as pain, swelling, trismus and dysfunction of the oral cavity during recovery. Secretory leukocyte protease inhibitor (SLPI) is one of innate immunity proteins that can inhibit the activation of macrophages. We are expecting the provision of SLPI can decrease excessive inflammatory response in healing after tooth extraction. This study was to investigate the administration of SLPI on cellular expression of NF-Kβ and IL-1β on wound macrophages of Rattus novergicus post tooth extraction. The research design is in vivo experimental study. In total, 20 rats were randomly divided into four groups (each group n=5) and underwent tooth extraction on left incisor teeth of mandible. One of the groups did not receive SLPI administration (control group) and the socket was stitched after tooth extraction. Meanwhile, the remaining three groups (experimental groups) were given SLPI administration after tooth extraction with three different doses (0.1 µM, 0.5 µM and 2.5 µM, respectively). After SLPI administration, the socket of experimental groups was stitched. The effects of SLPI administration were evaluated by counting at the percentage of NF-Kβ translocation and the expression of expression of IL-1 in macrophages cells of the rat socket using immunohistochemistry analysis. The cellular expression of NF-Kβ and IL-1β were significantly decreased (p < 0.05) on groups with SLPI may decrease cellular expression of NF-Kβ and IL-1β on wound macrophages cells of rats post tooth extraction in a dosedependent manner.
EDUKASI KESEHATAN DAN PENYAKIT MULUT BAGI PARA LANSIA TERKAIT PENYAKIT SISTEMIK Cahyati, Miftakhul; Hidayat, Lukman Hakim; Putri, Agustine Hanafi; Swastirani, Astika; Hakim, Meilia Aquina; Komarruzaman, Abdul Razaq; Firdaus, Devan Maulana; Riandi, Muhammad Alvaro; Sukadi, Zefanya Nicko; Hasan, Muhammad Fathur Rouf
JMM (Jurnal Masyarakat Mandiri) Vol 9, No 2 (2025): April
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v9i2.29115

Abstract

Abstrak: Seiring bertambahnya usia, lansia rentan mengalami berbagai masalah kesehatan gigi dan mulut. Umumnya masyarakat beranggapan bahwa masalah gigi merupakan bagian alami dari proses penuaan, dan lebih parah jika masyarakat beranggapan bahwa masalah gigi dan mulut merupakan hal yang sepele. Sehingga kegiatan pengabdian ini bertujuan untuk memberikan edukasi kesehatan dan penyakit mulut bagi para lansia terkait penyakit sistemik. Pelaksanaan kegiatan dilakukan dengan metode sosialisasi kemudian dilanjutkan dengan pemeriksaan kesehatan. Tim pelaksana kegiatan terdiri dari 7 Dosen FKG UB, 20 Mahasiswa FKG UB, sedangkan mitra sekaligus peserta sebanyak 44 orang lansia yang berasal dari Desa Sumberejo dan Desa Kalisongo. Sistem evaluasi menggunakan kuesioner untuk mengukur tingkat pemahaman peserta sebelum dan sesudah kegiatan. Hasil evaluasi menunjukkan adanya peningkatan pemahaman peserta yang signifikan, seperti pengetahuan tentang diabetes mellitus dan dampaknya terhadap kesehatan mulut. Responden yang menyatakan "tahu," awalnya sebanyak 11 responden meningkat drastis menjadi 33 responden (50%). Secara garis besar kegiatan edukasi tentang kesehatan gigi dan mulut dalam kegiatan pengabdian ini mampu memberikan dampak positif. Tim pengabdian berharap, kegiatan pengabdian ini dapat mendorong perubahan perilaku menuju praktik kebersihan gigi dan mulut yang lebih baik.Abstract: As people age, the elderly become increasingly susceptible to various dental and oral health problems. Generally, people assume that dental problems are a natural part of the ageing process, and it is worse if people assume that dental and oral problems are trivial. So this community service activity aims to provide health and oral disease education for the elderly regarding systemic diseases. The implementation of the activity was carried out using the dissemination method and then continued with a health check. The activity implementation team consists of 7 FKG UB lecturers, 20 FKG UB students, while the partners and participants are 44 elderly people from Sumberejo Village and Kalisongo Village. The evaluation system uses a questionnaire to measure participants' level of understanding before and after the activity. The evaluation results showed a significant increase in participants' understanding, such as knowledge about diabetes mellitus and its impact on oral health. Respondents who stated "know," initially 11 respondents, increased drastically to 33 respondents (50%). Generally, educational activities about dental and oral health in this community service activity were able to provide a positive impact. The community service team hopes that this community service activity can encourage behavioural changes towards better dental and oral hygiene practices.
Co-Authors Edi Widjajanto Firdaus, Devan Maulana Fitriyani, Delfi Hakim, Meilia Aquina Hidayat, Lukman Hakim Komarruzaman, Abdul Razaq Komaruzzaman, Abdur Razaq Miftakhul Cahyati Muhammad Fathur Rouf Hasan Noerpuspita, Putri Nur Permatasari Riandi, Muhammad Alvaro Sukadi, Zefanya Nicko Swastirani, Astika