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<![CDATA[PENGARUH PEMBERIAN MORFIN DOSIS LETHAL TERHADAP PERTUMBUHAN LARVA LALAT Chrysomya sp. PADA MEDIA BANGKAI TIKUS Rattus norvegicus GALUR WISTAR ]]>
<![CDATA[Fadhlurrahman, Ahmad Reza]]>;
<![CDATA[Baskoro, Aswin D]]>;
<![CDATA[Permatasari, Nur]]>
<![CDATA[ MANDALA of Health Vol 6, No 1 (2013): Mandala Of Health ]]>
Publisher : <![CDATA[Jurusan Kedokteran FK Unsoed ]]>
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<![CDATA[Death is the end of life. To identify unproper death on corpses, we use Post Mortem Interval (PMI). Insect evidence on the corpses can be used to estimate the Post Mortem Interval, however many factors including drugs may affect the rate of fly larva growth. Two rats with average BW 200 grams were used in this experimental study in order to analyze the influence of morphine on growth rate of fly larvae. One rat were given 120 grams of morphine orally (LD50 = 461mg/KgBW), and the other were killed by cervical dislocation and used as control. The rats were then simultaneously killed and caged individually into Chrysomya sp. cages to let the flies deposit their eggs on the rat corpses. Five developing larvae were sampled twice daily to determine the body length, weight and the growth rate until they were emerging to be adult. Result of this study showed that the length and the weight were lower and the growth of Chrysomya sp. larvae in rat corpses containing morphine were faster than control. The significant result occured at third stadium (p < 0,005) This result suggested that morphine can precipitate the growth rate of fly larvae.]]>
<![CDATA[The Effectiveness Of Tofu Liquid Waste As A Natural Phytoestrogen For Mandibular Bone Of Ovariectomized Rats ]]>
<![CDATA[Aquina, Meilia]]>;
<![CDATA[Permatasari, Nur]]>
<![CDATA[ Insisiva Dental Journal Vol 1, No 1 (2012) ]]>
Publisher : <![CDATA[Insisiva Dental Journal ]]>
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<![CDATA[Estrogen is a steroid compound that has many benefits for the bodys physiology.Hypoestrogenic women could have periodontitis in their mouth. Hormonereplacement therapy (HRT) is a therapy that used to reduce the disturbance causedby estrogen deficiency. However, HRT has many side effects. Theoretical studyshows that isoflavones in tofu liquid waste has an element of a steroid compound.The purpose of this study was to prove the effectiveness of isoflavones in the tofuliquid waste by examining the microscopic structure, estrogen receptor expressionand MDA levels in rat mandibular bone post-ovariectomy. This research methoduse a true experimental laboratory with randomized post test control group design.Twenty-four female wistar rats were divided randomly into six groups, consistedof a group of normal rat that doesânt ovariectomized (C1), 4 weeksovariectomized rats (C2), 8 weeks ovariectomized rats (C3) but no tofu liquidwaste was given, and 8 weeks ovariectomized rats that given tofu liquid waste atthe end of the 4th week of ovariectomy with three different doses (C4 = 1.2, C5 =6; C6 = 12 ml / kg). Histopathological slide used to see the changes resulted in anumber of osteoclasts, osteocytes, periodontal ligament width, alveolar boneheight, the amount of estrogen receptor expression and MDA levels. The resultsof statistical tests show that there is a difference in the rats between six differentgroups (ANOVA, p <0.05) and there is a close relationship between the dose ofthe tofu liquid waste with all parameter. The conclusion of this study is tofuliquid waste could improve the microscopic structure, estrogen receptorexpression and MDA levels in rat mandibular bone post-ovariectomy.]]>
<![CDATA[EffectOf Panax Ginseng Extract For The Increased Number Of Fibroblasts Cells After Tooth Extraction ]]>
<![CDATA[Rizky Hutomo, Ferdian]]>;
<![CDATA[Permatasari, Nur]]>;
<![CDATA[Andari Wulan, Kartika]]>
<![CDATA[ Insisiva Dental Journal Vol 1, No 1 (2012) ]]>
Publisher : <![CDATA[Insisiva Dental Journal ]]>
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<![CDATA[The process of tooth extraction can lead to injury. One of the factors that influencethe process of wound healing after tooth extraction is the number of fibroblastcells. The content of saponins can increase the number of fibroblasts cells aftertooth extraction. Asian ginseng plants known to contain saponins (ginsenoside).The purpose of this study was to determine the effect of Asian ginseng extract(Panax ginseng extract) for the increased number of fibroblasts cells after toothextraction. The research method used is in vivo experimental design with thedesign methods Randomized Post Test Only Control Group Design. In this studyused twentty male rattus novergicus and divided into four group, consisting ofcontrol group (K1) were not given Asian ginseng extract, treatment groupsnumber one (K2) were given 25mg/Rattus novergicus/day doses of Asianginseng, treatment groups number two (K3) were given 50mg/ Rattusnovergicus/day doses of Asian ginseng, and treatment groups number three (K4)were given 75mg/Rattus novergicus/day doses of Asian ginseng. Histopathologicpreparations used for counting the number of fibroblasts cells. The results ofstatistical tests indicate there are differences in the number of fibroblast cells inRattus novergicus between the four different groups (ANOVA, p <0.05) and thereis a very strong correlation between increasing doses of ginseng extract with anumber of fibroblast cells in Rattus novergicus tooth socket (Pearson, R = 0.915 p<0.05). The conclusion of this study is Asian ginseng extract can increase thenumber of fibroblasts in the tooth socket after tooth extraction, it is recommendedthat research about the amount of saponin in Asian Ginseng extract]]>
<![CDATA[PENGARUH PEMBERIAN LIMBAH CAIR TAHU SEBAGAI ISOFLAVON TERHADAP JUMLAH SEL OSTEOKLAS PADA TULANG MANDIBULAR TIKUS WISTAR (RATTUS NORVEGICUS) PASCA OVARIEKTOMI ]]>
<![CDATA[Devitaningtyas, Nungky]]>;
<![CDATA[Permatasari, Nur]]>;
<![CDATA[Sidharta, Rudhanton]]>
<![CDATA[ E-Prodenta Journal of Dentistry Vol 2, No 2 (2018) ]]>
Publisher : <![CDATA[Fakultas Kedokteran Gigi UB ]]>
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DOI: 10.21776/ub.eprodenta.2018.002.02.3
<![CDATA[Menopause pada wanita akan menyebabkan terjadinya defisiensi hormon estrogen. Hormon estrogen memiliki peran dalam pembentukan dan remodeling tulang termasuk tulang alveolar dengan mempertahankan keseimbangan kerja osteoblas dan osteoklas. Penurunan hormon ini mengakibatkan proses remodeling tulang terganggu. Fitoestrogen dapat merangsang aktivitas osteoblastik dan menghambat osteoklas. Limbah cair tahu merupakan salah satu produk sampingan olahan kedelai yang masih memiliki kandungan fitoestrogen. Tujuan: untuk membuktikan efektivitas pemberian limbah cair tahu sebagai sumber fitoestrogen terhadap penurunan jumlah sel osteoklas pada tulang mandibula pasca ovariektomi. Metode: Penelitian ini menggunakan tikus wistar dengan 6 kelompok, yaitu K1 (tidak diovariektomi dan tidak diberi limbah cair tahu), K2 (ovariektomi 4 minggu dan tidak diberi limbah cair tahu), K3 (ovariektomi 8 minggu dan tidak diberi limbah cair tahu), K4 (ovariektomi + 1,2 ml/kgBB limbah cair tahu), K5 (ovariektomi + 6 ml/kgBB limbah cair tahu), K6 (ovariektomi + 12 ml/kgBB limbah cair tahu). Pemberian limbah cair tahu melalui sonde 3 kali sehari selama 4 minggu. Penurunan jumlah osteoklas diamati secara mikroskopis. Hasil: Uji Oneway anova, (p<0) terdapat perbedaan jumlah sel osteoklas tikus Wistar antar kelompok. Uji Post Hoc Multiple Comparison, K6 terdapat perbedaan signifikan dibandingkan K4 dan K5 dimana jumlah sel osteoklas K6 paling sedikit. Kesimpulan: Pemberian limbah cair tahu dengan dosis 12 mg/kgBB  dapat menurunkan jumlah sel osteoklas pada mandibula tikus pasca ovariektomi. Kata kunci: limbah cair tahu, fitoestrogen, sel osteoklas, ovariektomi]]>
<![CDATA[Vitamin E Mempertahankan Kemampuan EPC yang Dipapar Glukosa Tinggi dalam Pelepasan NO dan Induksi Migrasi Sel Endotel ]]>
<![CDATA[Nugrahenny, Dian]]>;
<![CDATA[Widodo, M Aris]]>;
<![CDATA[Permatasari, Nur]]>
<![CDATA[ Jurnal Kedokteran Brawijaya Vol 27, No 1 (2012) ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Brawijaya ]]>
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DOI: 10.21776/ub.jkb.2012.027.01.2
<![CDATA[Peran sel progenitor endotel (EPC) dalam angiogenesis terganggu pada diabetes. Penelitian dilakukan untuk mengamati efek  vitamin  E  pada  kemampuan  EPC  yang  dipapar glukosa  tinggi  dalam melepaskan  NO dan  menginduksi  migrasi  sel endotel.  Sel mononuklear diisolasi dari darah perifer subjek sehat.  Pada hari ke-7, kultur EPC diberikan glukosa normal (5 mM) dengan atau tanpa pemberian vitamin E 22 µM atau 50 µM sebagai kontrol, atau diberikan glukosa tinggi (22 mM) dengan  atau  tanpa  pemberian  vitamin  E  22  µM  atau  50  µM  selama  24  jam.  Fungsi  EPC  dinilai  dengan  mengevaluasi  migrasi HUVEC setelah pemberian supernatan EPC. Migrasi HUVEC dinilai dengan uji migrasi wound-healing. Konsentrasi NO dan H O  EPC diukur dengan uji kolorimetrik.  Superoksid EPC dinilai dengan uji NBT .  Pemberian glukosa tinggi mengakibatkan 2 2penurunan kemampuan EPC dalam menginduksi migrasi HUVEC, penurunan NO EPC, serta peningkatan superoksid dan H O  EPC.  Pemberian  vitamin  E  50  µM  dapat  menghambat  penurunan  kemampuan  EPC  dalam  menginduksi  migrasi 2 2HUVEC,  dan  efek  ini  terkait  dengan  konsentrasi  NO,  superoksid  dan  H O  EPC.  Pemberian  vitamin  E  dapat 2 2mempertahankan kemampuan EPC yang dipapar glukosa tinggi dalam melepaskan NO dan menginduksi migrasi HUVECs melalui  hambatan  peningkatan  superoksid  dan  H O  EPC.2 2Kata  Kunci:  EPC,  glukosa  tinggi,  NO,  ROS,  vitamin  E]]>
<![CDATA[Pengaruh Ekstrak Jintan Hitam terhadap MDA dan Sel Spermatogonium Tikus yang Dipapar Asap Rokok Kretek Subakut ]]>
<![CDATA[P, Happy Kurnia]]>;
<![CDATA[Permatasari, Nur]]>;
<![CDATA[Subandi, Subandi]]>
<![CDATA[ Jurnal Kedokteran Brawijaya Vol 26, No 3 (2011) ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Brawijaya ]]>
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DOI: 10.21776/ub.jkb.2011.026.03.6
<![CDATA[Radikal  bebas  dalam  asap  rokok  diketahui  dapat  menyebabkan  gangguan  infertilitas.  Aktivitas  radikal  bebas  dapat dihambat oleh antioksidan seperti yang terkandung dalam jintan hitam (thymoquinone, nigellone, carvacrol, t-anetholedan 4-terpineol). T ujuan penelitian ini  adalah untuk mengetahui pengaruh ekstrak jintan hitam terhadap kadar Malon Di Aldehid  (MDA)  testis  dan  jumlah  sel  spermatogonium  testis  tikus  yang  dipapar  asap  rokok  kretek  selama  21  hari  (subakut). Penelitian eksperimental ini menggunakan 20 ekor tikus (Rattus norvegicus) strain Wistar jantan yang dibagi menjadi 5 kelompok,  terdiri  dari  kelompok  kontrol  negatif,  kelompok  kontrol  positif ,  kelompok  perlakuan  1,  2,  dan  3  (masing-masing dipapar asap rokok kretek dan diberi ekstrak jintan hitam dosis 0,6; 1,2; 2,4 g/kgBB/hari secara berurutan). Kadar MDA testis  diukur  menggunakan  metode  Thio  Barbituric  Acid  test  (TBA  T est).  T estis  tikus  dijadikan  preparat  histopatologi menggunakan  pengecatan  Haematoxcylin  Eosin  (HE),  untuk  dihitung  jumlah  sel  spermatogonium  yang  melekat  pada membrana  basalis.  Dapat  disimpulkan  bahwa  jintan  hitam  mempunyai  efek  antioksidan,  yaitu  dapat  mencegah penurunan jumlah  sel spermatogonium pada tubulus  seminiferus testis  tikus strain Wistar melalui hambatannya pada pembentukan  peroksidasi  lipid  (MDA)  akibat  paparan  asap  rokok  kretek  subakut.]]>
<![CDATA[EFEK KOMBINASI ARTEMISININ DAN N-acetylcysteineTERHADAP KADAR Malondialdehyde(MDA) OTAK DAN PARU MENCIT GALUR Balb/c YANG DIINFEKSI Plasmodium berghei ]]>
<![CDATA[Fitri, Loeki Enggar]]>;
<![CDATA[Iskandar, Agustin]]>;
<![CDATA[Permatasari, Nur]]>;
<![CDATA[Gunawan, Joko Agus]]>;
<![CDATA[Indrawan, Khadafi]]>
<![CDATA[ Jurnal Kedokteran Brawijaya Vol 24, No 2 (2008) ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Brawijaya ]]>
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DOI: 10.21776/ub.jkb.2008.024.02.4
<![CDATA[Cerebral and lung damage during malaria infection is believed to be caused by free radicals activitiesthat are produced during immunology process. The free radicals react with lipid component of cellular membrane which generates malondialdehyde (MDA) as its end-product. The aim of the research was to determine whether combination of artemisinin and NAC was moreeffective in decreasing cerebral and lung MDA level compared to artemisinin mono-therapy . The researchwas post-test-control-only design using 5 groups consisted of group A (negative control group), group B mice which infected with P.berghei without therapy (positive control group), group C mice which infected with P.berghei and received artemisinin mono-therapy (0.04 mg/g BW for 7 days), group D mice which infected with P.berghei and received artemisinin in combination with NAC (1 mg/g BW for 7 days) and group E mice which infected with P.berghei and received artemisinin in combination with NAC (1 mg/g BW for 3 days and tapered into ½ mg/g BW for 4 days). On the 3rd, 5th,and 7thday, 3 mice from each group were scarified and assayed for MDA level. On the 3rd day, a decreasing trend of cerebral and lung MDA level wasobserved on all treatment groups. On the 5thday, a decreasing trend of cerebral and lung MDA level wasobserved in group that received artemisinin and NAC whereas group’s that received artemisinin mono-therapy increased. Cerebral and lung MDA level of groupthat received artemisinin mono-therapy was significantly different with group that received combination of artemisinin and NAC in constant dose (p = 0.014) and with group that received combination artemisinin  and NAC in tapering dose (p = 0.004).]]>
<![CDATA[EFEK HAMBATAN EKSTRAK DAUN CEPLUKAN (Physalis minima L)TERHADAP KONTRAKTILITAS OTOT POLOS USUS HALUS TERPISAH MARMUT DENGAN STIMULASI METAKOLIN EKSOGEN ]]>
<![CDATA[Tarannita, Citra]]>;
<![CDATA[Permatasari, Nur]]>;
<![CDATA[Sudiarto, Sudiarto]]>
<![CDATA[ Jurnal Kedokteran Brawijaya Vol 22, No 1 (2006) ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Brawijaya ]]>
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DOI: 10.21776/ub.jkb.2006.022.01.4
<![CDATA[Physalis sp. has lots of merits as a kind of traditional medicine and one of them is its function as an alternatif treatment for diarrhea. Physalis minima leaf contains alkoloid atropine which is assumed can inhibit the contractionof guinea pig’s isolated ileum smooth muscle. This research was to know the effect of Physalis minima leaf extract toward the contraction of small intestine smooth muscle. This research was  an experimental study using “The Post Control GroupDesignâ€, and guinea pig’s isolated ileum as samples. The samples  consisted of five guinea pigs, each sample was given four kinds of treatment. The control was given metacholine at the  dose of 10 -5 without Physalis minima leaf extract. Before givingmetacholine at the dose of 10 -5 , the samples were given the first dosage of Physalis minima leaf extract (0.15%), the second dose (0.30%) and the third dose (0.45%) so getting four graphs for each sample. The level of contraction was recorded by using kymograph. The result showed that  the ileum contraction of the third group was inhibited (One Way ANOVA, p=0.041), and there was a relation between the increasing dosage of Physalis minima leaf extract and the decreasing ileum contraction (simple linear regression, with R=-0.608 p=0.04 and regression equation y=52.150 – 7.660x).]]>
<![CDATA[Karboksimetil Kitosan Menurunkan Degranulasi Mast Cell yang Diinduksi Oleh Ovalbumin ]]>
<![CDATA[Ibrahim, Mohamad Nur]]>;
<![CDATA[Widjajanto, Edi]]>;
<![CDATA[Permatasari, Nur]]>;
<![CDATA[Sabarudin, Akhmad]]>
<![CDATA[ Jurnal Kedokteran Brawijaya Vol 25, No 1 (2009) ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Brawijaya ]]>
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DOI: 10.21776/ub.jkb.2009.025.01.2
<![CDATA[ABSTRACTOvalbumin is known as mast cell degranulating agent through the FCεRI aggregation. Carboxymethylchitosan (CMCs), a biocompatible cationic polymer was evaluated to reduces mast cell degranulation inducedby ovalbumin. In this experiment, wistar rats were darboxymethyl chitosanivided into 5 groups which consist of 1 control group and 4allergen groups. Among the allergen groups, 3 groups were treated with carboxymethyl chitosan/CMCs(doses : 0,25 mg, 0,50 mg and 1,00 mg) for 22 days. The result showed a significant (P<0,01) reduction inmast cell degranulation in allergen groups. This finding indicate that CMCs possesses antiinflammationactivity mediated by reducing of mast cell degranulation.Keywords : ,c mast cell degranulation]]>
<![CDATA[Mekanisme Kerja Benalu Teh pada Pembuluh Darah ]]>
<![CDATA[AS, Nour Athiroh]]>;
<![CDATA[Permatasari, Nur]]>
<![CDATA[ Jurnal Kedokteran Brawijaya Vol 27, No 1 (2012) ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Brawijaya ]]>
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DOI: 10.21776/ub.jkb.2012.027.01.1
<![CDATA[Secara garis besar ada dua jenis  penatalaksanaan  terhadap hipertensi yaitu menggunakan obat-obatan dan non obat. Adapun penatalaksanaan secara non obat, salah satunya dengan terapi  herbal dengan memanfaatkan benalu teh dari famili  Loranthaceae  misalnya  (Viscum  album,  Dendrophtoe  pentandra  (L.)  Miq, Scurrula  parasitica,  Scurulla  oortiana,  dan Macrosolen javanus)  yang  berpotensi  sebagai  antihipertensi  (vasodilator). Mekanisme  kerja  dari flavonoid  benalu teh sebagai vasodilator karena peran otot polos dan endotel pembuluh darah. Pada umumnya  pengobatan hipertensi yaitu pada   organ  target  pembuluh  darah  (sistem  vaskular).  Flavonoid  benalu  teh  dalam  hal  ini  quercetin  mampu  bekerja langsung pada otot polos pembuluh arteri dengan menstimulir atau mengaktivasi Endothelium Derived Relaxing Factor(EDRF) sehingga menyebabkan vasodilatasi. Beberapa penelitian tentang pengaruh flavonoid tanaman teh pada fungsi endotel bahwa kandungan dari flavonoid yaitu polifenol dapat meningkatkan aktivitas dari Nitric Oxide Synthase (NOS) pada  sel  endotel  pembuluh  darah.  Quercetin  mempunyai  potensi  meningkatkan  produksi  Nitric Oxide  (NO)  di  sel  endotel. Zat  aktif  tersebut  mampu  mensintesa  NO  dalam  endotel  dan  berdifusi  secara  langsung  ke  otot  polos  selanjutnya merangsang guanylate cyclase untuk membentuk cGMP sehingga terjadi vasodilatasi.]]>
