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All Journal Al-Kimia Jurnal Farmasi Tinctura
Lady Yunita Handoyo, Diana
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Chemistry Medicine & Pharmacology

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Molecular Docking of Physalis angulata and Schleichera oleosa as a Potential Inhibitor of Dengue methyltransferase Hasan, Rahmawaty; Lady Yunita Handoyo, Diana; Zukhruf, Laila
Al-Kimia Vol 11 No 2 (2023): DESEMBER
Publisher : Study Program of Chemistry - Alauddin State Islamic University of Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-kimia.v11i2.40433

Abstract

Indonesia as the 2nd country with the largest Dengue Hemorrhagic Fever (DHF) cases among 30 countries with endemic areas. Oral infusion of Physalis angulata and Schleichera oleosa are potential plants that is traditionally applied for DHF treatment. This study aimed to analyze the chemical compounds of Physalis angulata and Schleichera oleosa as an alternative therapy to DHF utilizing the molecular docking procedure. The methods are macromolecule and ligand preparation, validation as well as molecular docking, data analysis and visualization. The compounds were downloaded from the PubChem database and dengue methyltransferase protein was obtained from PDB (1L9K). Molecular docking has interacted with the Autodock and analyzed by Pymol, Discovery Studio Visualizer and Ligplot. The results revealed that the test ligands had lower binding energies than the SAH as a native ligand, specifically 14-Hydroxyixocarpanolide -10.69 kcal/mol as a potential compound from Physalis angulata and Schleicherastatin 5 -10.25 kcal/mol as a potential compound from Schleichera oleosa. With hydrogen bonds and hydrophobic pockets, all of the test ligands bind the NS5 dengue methyltransferase active site. The results suggested that Physalis angulata and Schleichera oleosa possess offering compounds for inhibiting NS5 dengue methyltransferase as a DHF treatment.
Potensi Ekstrak Daun Widuri (Calotropis gigantea) Sebagai Antiinflamasi Secara Topikal Rahman, Fauzi; Lady Yunita Handoyo, Diana
Tinctura Vol 5 No 2 (2024): Jurnal Farmasi Tinctura
Publisher : Program Studi S1 Farmasi Fakultas Ilmu Kesehatan Universitas Ibrahimy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35316/tinctura.v5i2.5073

Abstract

ABSTRAK Penggunaan obat tradisional berbasis tanaman herbal masih banyak digunakan pada masyarakat. Salah satu tanaman herbal yang secara tradisional masih digunakan adalah Calotropis gigantea atau widuri yang mempunyai aktivitas farmakologi dimana salah satunya sebagai antiinflamasi. Artikel review ini bertujuan untuk mengkaji potensi ekstrak daun widuri dalam formulasi topikal sebagai antiinflamasi. Metode yang digunakan adalah literatur review yang diperoleh dari berbagai sumber. Berdasarkan berbagai referensi yang digunakan, daun widuri mempunyai kandungan flavonoid yang mempunyai aktivitas sebagai antiinflamasi. Selain penggunaan seacara oral, ekstrak daun widuri dapat diformulasikan dalam sediaan topikal. Oleh karena itu, eksrak daun widuri berpotensi untuk diformulasikan secara topikal sebagai antiinflamasi. Kata kunci : Widuri, Calotropis gigantea, Antiinflamasi, Topikal
Co-Authors Fauzi, Rahman Hasan, Rahmawaty Zukhruf, Laila