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All Journal Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Jurnal Widya Medika
Susatyo, Jeffry Adijaya
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Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health Other

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THE USAGE COMPARISON OF CEFTRIAXONE AND CHLORAMPHENICOL FOR TYPHOID FEVER TREATMENT: AN EVIDENCE BASED CASE REPORT Susatyo, Jeffry Adijaya
Indonesian Journal of Tropical and Infectious Disease Vol. 6 No. 3 (2016)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (128.699 KB) | DOI: 10.20473/ijtid.v6i3.3255

Abstract

Typhoid fever is a disease caused by the gram-negative bacterium Salmonella typhi. Since its introduction in 1949, chloramphenicol has become the first-line treatment of typhoid fever for decades. Until now, chloramphenicol is still the first line treatment of typhoid fever in rural areas in Indonesia, due to its low cost. However, in addition to the problem of bacterial resistance, chloramphenicol is known to cause some side effect such as bone marrow suppression. Currently, many other antibiotics are used as the regimens for the treatment of typhoid fever, one of which is ceftriaxone. However, there are evidences on reemergence of chloramphenicol sensitivity in typhoid fever treatment. This report is created to answer the clinical question on whether ceftriaxone is more effective compared to chloramphenicol as the first-line treatment of typhoid fever. A structured search was performed on PubMed, EBSCO, and ScienceDirect and after a screening process and appraisal using the criteria from Center of Evidence Based Medicine at Oxford University, only one article was selected. The article shows higher efficacy of ceftriaxone in term of defervescence rate (P = 0.0001). No other study that compares the efficacy of ceftriaxone and chloramphenicol for typhoid fever treatment during the last ten years could be found during article searching. In conclusion, ceftriaxone shows better efficacy in the treatment of typhoid fever compared to chloramphenicol but with the rise of microbial sensitivity to chloramphenicol in recent years, more studies on this topic are needed to support this conclusion.
RELATION BETWEEN LENGTH OF STAY AND ANTI-FILARIAL IgG4 LEVEL IN PONDOK GEDE SUB-DISTRICT, BEKASI DISTRICT, WEST JAVA Susatyo, Jeffry Adijaya; Wibowo, Heri
Folia Medica Indonesiana Vol. 53 No. 3 (2017): September 2017
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (110.6 KB) | DOI: 10.20473/fmi.v53i3.6458

Abstract

Filariasis is a contagious disease caused by worms of the genus Filaria which transmitted through the bite of various species of mosquitoes. In Indonesia, the existence of filariasis cases are still very concerning. Jati Sampurna and Jati Karya villages in Pondokgede Sub-district, Bekasi District, West Java have been known as filariasis endemic area. Length of stay is presumed as one of many factors that affects filariasis occurrence in those villages. This study aimed to determine the distribution of anti-filarial IgG4 on the region and its comparison with the length of stay and residence status. This study was based on secondary data. Secondary data were obtained from primary research data done by cross-sectional method. These data were used to assess the correlation of filarial infection risk factors in pregnant women living in endemic areas based on the distribution of anti-filarial IgG4 in Pondok Gede, Bekasi district, West Java. The study showed that there was an increase in anti-filarial IgG4 against residence status (p=0.017) and a positive correlation between the number of anti-filarial IgG4 with length of stay in years (p=0.003).
57-YEAR-OLD WOMAN WITH OESOPHAGEAL VARICES AND SUSPECTED NON- CIRRHOTIC PORTAL HYPERTENSION Muliyanto, Jovan Amadeo; Christopher; Utami, Karina Saraswati; Margovio; Rencong, Gunady Wibowo; Susatyo, Jeffry Adijaya
JURNAL WIDYA MEDIKA Vol. 11 No. 2 (2025): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v11i2.7707

Abstract

Non-cirrhotic portal hypertension (NCPH) is characterized by portal hypertension, splenomegaly, hypersplenism, and pancytopenia without histological evidence of cirrhosis. Causes include chronic infection, toxin exposure, thrombophilia, immunological disorders, and genetic abnormalities. The diagnosis of NCPH remains challenging because symptoms often mimic cirrhotic portal hypertension and access to definitive tests such as liver biopsy is limited. We report the case of a 57-year-old woman with upper gastrointestinal bleeding and oesophageal varices without clinical or radiological signs of cirrhosis. Conservative management with variceal ligation and beta-blockers was used because advanced procedures such as transjugular intrahepatic portosystemic shunt (TIPS) were not available. This case demonstrates the challenges in diagnosing and treating NCPH in resource-limited settings and the importance of supportive care and early detection.
Co-Authors Christopher Heri Wibowo Margovio Muliyanto, Jovan Amadeo Rencong, Gunady Wibowo Utami, Karina Saraswati