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All Journal INDONESIAN JOURNAL OF PHARMACY
Alam, G.
Department of Pharmacy, Hasanuddin University, Makassar, Indonesia
Medicine & Pharmacology

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Tracheospasmolytic activity of vitetrifolin-E isolated from the leaves of Vitex trifolia L. Alam, G.; Gandjar, I.G.; Hakim, Lukman; Timmerman, H.; Veerporte, R.; Wahyuono, S.
Indonesian Journal of Pharmacy Vol 14 No 4, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (463.271 KB) | DOI: 10.14499/indonesianjpharm0iss0pp188-194

Abstract

In searching of tracheospasmolytic active compounds from Vitex trifolia, we are now reporting isolation and identification of vitetrifolin-E from active fraction obtained from n-hexane extract of V. trifolia. Vitetrifolin-E blocked spontaneous contraction of male guinea pig trachea induced by histamine and was active in a model using sensitized guinea pig trachea stimulated by ovalbumin. Vitetrifolin-E inhibited tracheal contraction by 22.6% at dose of 1.3 x 10-4 M and by 86.1% at dose of 4.10-4 M. In a model using sensitized male guinea pig trachea, vitetrifolin-E also inhibited the contraction 83.5% (1.3 x 10-5 M).Keywords: vitetrifolin-E, Vitex trifolia, tracheospasmolytic
Co-Authors Gandjar, I.G. Hakim, Lukman Timmerman, H. Veerporte, R. Wahyuono, S.