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All Journal INDONESIAN JOURNAL OF PHARMACY
Asif, Mohammad
Department of Pharmacy, GRD (P.G) Institute of Management and Technology, Dehradun, 248009, India.
Medicine & Pharmacology

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SYNTHESIS AND ANALGESIC ACTIVITY OF 6-(MNITROPHENYL)-4-SUSTITUTED BENZYLIDENE-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE DERIVATIVES Asif, Mohammad
Indonesian Journal of Pharmacy Vol 23 No 4, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (255.072 KB) | DOI: 10.14499/indonesianjpharm23iss4pp254-258

Abstract

Many  research  groups  have  been  interested  in  3(2H)-pyridazinones  for  the  development  of  potential  analgesic  and  antiinflammatory  agents.  Stimulated  by  these  findings,  three  6-(mNitrophenyl)-4-sustituted  benzylidene-4,5-dihydropyridazin-3(2H)-ones (IVa-IVc) have been synthesized and evaluated for analgesic activity  against  hot  plate  method.  Compounds IVa-IVc were prepared from 6-m-nitrophenyl-4,5-pyridazin-3(2H)-one by condensation  with  respective  aldehydes.  All  compounds  (IVa-IVc)  having nitro  phenyl  and  benzylidene  groups  at  position  6  and  4  of  the pyridazinone  ring  receptively.  All  compounds  (IVa-IVc)  showed significant  analgesic  activity  when  compare  to  control  group  and were found less potent than reference drug aspirin.Key words:Pyridazinones, analgesic, benzylidene, nitrophenyl.
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