SYNTHESIS AND ANALGESIC ACTIVITY OF 6-(MNITROPHENYL)-4-SUSTITUTED BENZYLIDENE-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE DERIVATIVES

Asif, Mohammad (Department of Pharmacy, GRD (P.G) Institute of Management and Technology, Dehradun, 248009, India.)

INDONESIAN JOURNAL OF PHARMACY
Vol 23 No 4, 2012

Many  research  groups  have  been  interested  in  3(2H)-pyridazinones  for  the  development  of  potential  analgesic  and  antiinflammatory  agents.  Stimulated  by  these  findings,  three  6-(mNitrophenyl)-4-sustituted  benzylidene-4,5-dihydropyridazin-3(2H)-ones (IVa-IVc) have been synthesized and evaluated for analgesic activity  against  hot  plate  method.  Compounds IVa-IVc were prepared from 6-m-nitrophenyl-4,5-pyridazin-3(2H)-one by condensation  with  respective  aldehydes.  All  compounds  (IVa-IVc)  having nitro  phenyl  and  benzylidene  groups  at  position  6  and  4  of  the pyridazinone  ring  receptively.  All  compounds  (IVa-IVc)  showed significant  analgesic  activity  when  compare  to  control  group  and were found less potent than reference drug aspirin.Key words:Pyridazinones, analgesic, benzylidene, nitrophenyl.