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Simbara, Ari
Faculty of Pharmacy, Universitas Ahmad Dahlan. Yogyakarta, Indonesia.
Medicine & Pharmacology

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Synthesis of Tetrahydro Pentagavunon-0 Ritmaleni, Ritmaleni; Simbara, Ari
Indonesian Journal of Pharmacy Vol 21 No 2, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (188.499 KB) | DOI: 10.14499/indonesianjpharm0iss0pp100-105

Abstract

Curcumin,  tetrahydrocurcumin,  and  monoketone  curcumin  analogue, pentagamavunone-0  (PGV-0),   have  been  investigated  as  antioxidant,  antiinflammatory  and  anticancer.  This  research  was  aimed  to  synthesise  the Tetrahydropentagamavunone-0  (THPGV-0)  compound  which  assumed  as  an active  metabolite  of  PGV-0.  The  hydrogenation  reaction  was  applied  to  the synthesis  of  THPGV-0  from  PGV-0  using  Pd/C  10  %  as  catalyst  at  room temperature.  The structure elucidation  was  analysed by  using  spectroscophy method. The synthetic result showed that THPGV-0 asa white crystalline powder in 25 % with melting point about 122-123 oC.Key words: pentagamavunone-0, Tetrahydropentagamavunone-0, hydrogenation
Co-Authors Ritmaleni, Ritmaleni