Synthesis of Tetrahydro Pentagavunon-0

Ritmaleni, Ritmaleni (Faculty of Pharmacy, Universitas Gadjah Mada. Yogyakarta, Indonesia.)
Simbara, Ari (Faculty of Pharmacy, Universitas Ahmad Dahlan. Yogyakarta, Indonesia.)

INDONESIAN JOURNAL OF PHARMACY
Vol 21 No 2, 2010

Curcumin,  tetrahydrocurcumin,  and  monoketone  curcumin  analogue, pentagamavunone-0  (PGV-0),   have  been  investigated  as  antioxidant,  antiinflammatory  and  anticancer.  This  research  was  aimed  to  synthesise  the Tetrahydropentagamavunone-0  (THPGV-0)  compound  which  assumed  as  an active  metabolite  of  PGV-0.  The  hydrogenation  reaction  was  applied  to  the synthesis  of  THPGV-0  from  PGV-0  using  Pd/C  10  %  as  catalyst  at  room temperature.  The structure elucidation  was  analysed by  using  spectroscophy method. The synthetic result showed that THPGV-0 asa white crystalline powder in 25 % with melting point about 122-123 oC.Key words: pentagamavunone-0, Tetrahydropentagamavunone-0, hydrogenation