., Pudjono
Faculty of Pharmacy, Universitas Gadjah Mada. Yogyakarta, Indonesia

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Modeling of p-aminophenol compounds as analgesic antiinflammatory based on biologic activity and structure relationship ., Pudjono; Susilowati, Sri Sutji; ., Rehana
Indonesian Journal of Pharmacy Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (185.644 KB) | DOI: 10.14499/indonesianjpharm0iss0pp144-150

Abstract

This  research  aim  was  to  find  out  the  new  compounds model  of  paminophenol derivates which have analgesic anti-inflammatory activity based on structure  and  biologic  activity  relationship  analysis  by  computation  methods. Seventeen  compounds  of  p-aminophenol  derivates  were  used  in  this  research, and  six  compounds  known  its  analgesic-antiinflammatory  activity  were  used  for determine  QSAR  equation  model.  This  research’s  result  was  a  QSAR  equation that  can  be  using  for  synthesis  the  higher  activity new  compound  of  paminophenol. Key  words  :  p-aminophenol  compounds,  analgesic  anti-inflammatory activity,  structure and activity relationship, QSAR equation, computation methods