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All Journal Majalah Patologi Indonesia Journal Research of Social Science, Economics, and Management
Jantika, Dewi
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Environmental Science Health Professions Public Health

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Analysis of the Accuracy of Clinical Diagnosis and PA Diagnosis in Appendectomy Patients at AN-NISA Tangerang Hospital Period 2019-2024 Siti Maryam, Sarah; Nurusshofa, Zahra; Anisah, Anisah; El Anshory, Riza; Jantika, Dewi
Journal Research of Social Science, Economics, and Management Vol. 4 No. 3 (2024): Journal Research of Social Science, Economics, and Management
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jrssem.v4i3.725

Abstract

Appendicitis is inflammation of the vermiform appendix caused by a blockage in the lumen of the appendix. Anatomic pathology examination is considered the gold standard in confirming the diagnosis of appendicitis, but this examination not always carried out. Method: in this study used descriptive cross-sectional with the aim of comparing the clinical diagnosis and Pathology Anatomy diagnosis of 80 cases of appendectomy at AN-NISA Tangerang Hospital during the period 2019-2024. This study also aims to look at the incidence of malignancy in appendectomy. The results of the 80 cases carried out showed that 7 cases were malignant, 8 cases of appendicitis tuberculosis, 4 cases of malignancy which were initially clinically diagnosed as non-malignant, and 4 cases of tuberculosis which were initially diagnosed as non-tuberculosis. This study found that age was associated with the incidence of malignancy in the appendix (P<0.05). This study also found that patients aged >40 years had a 1,233 times higher risk of experiencing malignancy in the appendix than patients aged <40 years. Conclusion: In a number of cases, clinically significant impacts were found if Pathology Anatomy examination was not carried out. This study recommends pathology anatomy examination during appendectomy, especially in the age group >40 years.
Perbedaan Ekspresi Epidermal Growth Factor Receptor (EGFR) pada Malignant Peripheral Nerve Sheath Tumor Derajat Tinggi dan Rendah serta Hubungannya dengan Faktor Prognostik Jantika, Dewi; Siregar, Nurjati Chairani; Wuyung, Puspita Eka
Majalah Patologi Indonesia Vol 27 No. 2, Mei 2018
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

Latar belakangMalignant peripheral nerve sheath tumor (MPNST), merupakan sarkoma jaringan lunak yang prognosis nya buruk karena tidak responsif terhadap kemoterapi. Epidermal growth factor receptor (EGFR) terlibat dalam transduksi sinyal mitogenik dan jalur proliferasi sel. Ekspresi EGFR yang tinggi pada tumor sudah dipakai untuk menentukan apakah tumor dapat diberikan terapi anti-EGFR. Tujuan penelitian ini adalah untuk melihat perbedaan ekspresi EGFR pada MPNST derajat tinggi dan derajat rendah serta ekspresi EGFR sebagai faktor prognostik.MetodePenenelitian ini merupakan penelitian potong lintang, restrospektif, deskriptif. Sampel terdiri atas 20 kasus MPNST derajat rendah dan 20 kasus MPNST derajat tinggi yang telah didiagnosis selama periode 2007-2015. Dilakukan pulasan imunohistokimia dengan antibodi monoklonal EGFR. Selanjutnya dilakukan scoring berdasarkan persentase sel dengan membrane dan atau sitoplasma yang berwarna coklat pada 500 sel/5 LPB : 0 (tidak terpulas), 1 (terpulas <10%), 2 (terpulas 10-30%), 3 (terpulas >30%). Perbedaan ekspresi EGFR pada MPNST derajat tinggi dan derajat rendah dianalisis menggunakan uji chi-square. Selain itu di analisis hubungan antara ekspresi EGFR dengan umur, lokasi dan ukuran tumor.HasilDitemukan ekspresi EGFR yang lebih tinggi pada MPNST derajat tinggi dibandingkan dengan MPNST derajat rendah yang secara statisitk bermakna (p=0,000). Tidak ditemukan hubungan antara ekspresi EGFR dengan umur, lokasi maupun ukuran tumor.KesimpulanEkspresi EGFR yang tinggi dapat digunakan untuk dasar memberikan terapi anti-EGFR pada MPNST derajat tinggi.
Co-Authors Anisah El Anshory, Riza Nurjati Chairani Siregar Nurusshofa, Zahra Puspita Eka Wuyung Siti Maryam, Sarah