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All Journal Jurnal Bisnis Terapan Magna Neurologica Acta Neurologica Indonesia
Suwandhi
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Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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SENSITIVITAS INVESTASI STUDI KASUS PADA PENINGKATAN KAPASITAS PABRIK GULA SRAGI PT.PERKEBUNAN NUSANTARA IX Dyah Puspasari; Suwandhi
Jurnal Bisnis Terapan Vol. 5 No. 2 (2021): Jurnal Bisnis Terapan
Publisher : Politeknik Ubaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/jbt.v5i2.4032

Abstract

This study aims to determine the sensitivity of the increase or decrease in the selling price of sugar and drops, then the investment value, and the cost of production to the IRR obtained from the investment decision to increase the capacity of the Sragi Sugar Factory. Hypothesis testing is carried out on the results of the calculation of investment analysis which includes several commonly used parameters, namely Net present value (NPV), Internal rate of return (IRR), Profitability Index (PI), and Payback Period (PP), in this case as a comparison used The results of the IRR calculation. The results of the sensitivity study found that the selling price has the highest sensitivity, then the second is the investment value, while the cost of goods manufactured has the lowest sensitivity. The results of tests carried out on three parameters show that there is a significant change between the Selling Price, Investment Value and Cost of Production with the calculation of the IRR of an investment.
The Analysis Study of Intravenous Immunoglobulin for Myasthenia Gravis: Insight from A Systematic Review Suwandhi
Acta Neurologica Indonesia Vol. 3 No. 02 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v3i02.65

Abstract

Introduction: Myasthenia gravis (MG) is a chronic autoimmune disorder characterized by impaired neuromuscular transmission, leading to muscle weakness and fatigue. Intravenous immunoglobulin (IVIg) has emerged as a key therapeutic option for MG, particularly in acute exacerbations and myasthenic crises. This systematic review evaluates the efficacy, safety, and optimal use of IVIg in MG management. Methods: Following SWiM guidelines, this review synthesizes data from randomized controlled trials, cohort studies, and other high-quality evidence published between 2015 and 2025. The analysis focuses on IVIg's mechanisms of action, including neutralization of autoantibodies, inhibition of complement activation, and modulation of cytokines. Results: Studies indicate that IVIg improves clinical outcomes in 73-76% of patients, with a favorable safety profile compared to plasma exchange (PLEX). However, questions remain regarding its role in chronic maintenance therapy, corticosteroid-sparing effects, and long-term outcomes. Emerging therapies, such as subcutaneous immunoglobulin (SCIG), FcRn inhibitors (e.g., efgartigimod), and complement inhibitors (e.g., zilucoplan), offer promising alternatives with potential advantages in convenience and specificity. Conclusion: While IVIg remains a cornerstone in MG management, the evolving therapeutic landscape provides new opportunities to enhance patient outcomes and quality of life. Future research should focus on long-term comparative studies, patient adherence, and cost-effectiveness to optimize MG treatment strategies. Keywords: Myasthenia gravis, intravenous immunoglobulin, IVIg, plasma exchange, FcRn inhibitors, complement inhibitors, corticosteroid-sparing, immunomodulation
Civamide Nasal Spray: A Breath of Fresh Air in Migraine and Cluster Headache Therapy? Insights from A Systematic Review Cyntia Arum; Danar Dwi Anandhika; Nabil Hajar; Moh. Iqbal Setiawan; Fatima Khiarun Nisa; Suwandhi; Firza Yoga Baskoro; Hera Dwi Priharti
Magna Neurologica Vol. 4 No. 1 (2026): January
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v4i1.2208

Abstract

Background: Migraines and cluster headaches are severe neurological disorders characterized by complex pathophysiological mechanisms, particularly involving the trigeminal nerve and vascular inflammatory responses. Both conditions primarily affect the trigeminal nerve, a key pathway in pain transmission, and are closely associated with vascular inflammation. Migraines are typically characterized by recurrent, unilateral, and intense headaches, whereas cluster headaches are marked by excruciating pain, often localized around the eye. These disorders are multifactorial, with various mechanisms contributing to their initiation and persistence. Civamide nasal spray, which modulates neural pathways, has emerged as a promising therapeutic option for targeted pain relief. This study aims to evaluate the effectiveness of Civamide nasal spray in managing these debilitating headaches. Objective: To assess the efficacy of civamide nasal spray in treating migraine and cluster headache attacks. Methods: This study followed the Synthesis without Meta-analysis (SWiM) guideline. A systematic search was conducted using a predefined query in Medline, Google Scholar, and Cochrane Central Library. Eight independent reviewers screened studies for eligibility based inclusion criteria and assessed the risk of bias using the Cochrane RoB 2.0 tool. Results: Two eligible studies were analyzed. Participants receiving civamide demonstrated a greater reduction in weekly headache frequency compared with those receiving a placebo. Additionally, civamide treatment was associated with decrease in pain intensity. Conclusion: The findings suggest that civamide nasal spray effectively reduces both the frequency and severity of headaches. Nonetheless, further investigations, particularly evaluating its long-term preventive use, are required to establish its clinical role in migraine and cluster headache management.
Co-Authors Cyntia Arum Danar Dwi Anandhika Dyah Puspasari, Dyah Fatima Khiarun Nisa Firza Yoga Baskoro Hera Dwi Priharti Moh. Iqbal Setiawan Nabil Hajar