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All Journal Buletin Farmatera Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Mardia, Andri Iskandar
Unknown Affiliation
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Effectiveness Of Leukoreduction And Washed Packed Red Blood Cells on Hemoglobin Increment And Side Effects In Post Transfusion Anemia Patients Gatot, Dairion; Mardia, Andri Iskandar
Buletin Farmatera Vol 6, No 3 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i3.8924

Abstract

Blood transfusion is one of the methods to treat anemia and packed red blood cells (PRC) are the most widely used blood component. Post transfusion results showed that increment of hemoglobin (Hb) does not always match the amount of PRC given. This is thought to be due to the recipient's immune reaction to the PRC component. Leukoreduction is an action to reduce leukocytes from the PRC component thereby reducing the risk of an immune reaction. Alternatively, another method called washed PRC can also be used. In this study, the researcher studied the effectivity of leukoreduction and washed PRC on Hb increase in post-transfusion anemia patients compared with the usual PRC. The researcher used a pre-test post-test group design method of 60 people who were divided into 3 groups (ordinary PRC, washed PRC, leukofiltered PRC). The results showed all three groups reached the transfusion target (a 75% increase in Hb) and there were no differences among the groups both in terms of achievement of the Hb target and the incidence of side effects. There were no differences in the success of transfusion and incidence of side effects among the three groups.
The Association Between The International Society On Thrombosis And Haemostasis- Disseminated Intravascular Coagulation Score And Early Mortality Of Acute Leukemia Patients tantri, Anita; Dairion Gatot; Lubis, Heny Syahrini; Mardia, Andri Iskandar
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 3 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i3.21198

Abstract

Background: Disseminated Intravascular Coagulation (DIC) is a serious complication frequently found in patients with acute leukemia and is associated with increased early mortality. The ISTH-DIC score is widely used to assess the severity of DIC. However, data on the association between ISTH-DIC score and early mortality in acute leukemia patients in Indonesia remains limited. Objective: To evaluate the association between ISTH-DIC score and early mortality (≤60 days) in acute leukemia patients at H. Adam Malik General Hospital, Medan. Methods: This was a retrospective cohort study involving 68 adult patients diagnosed with acute leukemia admitted from January 2022 to June 2024. Medical records were reviewed to collect laboratory parameters (platelet count, prothrombin time [PT], fibrinogen, and D-dimer) to calculate the ISTH score. Statistical analysis was performed using bivariate and multivariate logistic regression. Results: The early mortality rate was 58.8%. A substantial proportion of patients had ISTH-DIC scores ≥5, but no statistically significant association was found between ISTH score and early mortality (p = 0.704). However, PT >1.2 seconds was significantly associated with early mortality (p < 0.001; OR 18.00). Platelet count, D-dimer, and fibrinogen levels showed no significant association. Conclusion: The ISTH-DIC score was not significantly associated with early mortality in acute leukemia patients, but individual components such as prolonged PT showed a strong correlation. Early coagulation assessment remains essential in identifying patients at risk of life-threatening complications.
Co-Authors Dairion Gatot, Dairion Lubis, Heny Syahrini tantri, Anita