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All Journal IJOEP : International Journal of Ecophysiology Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Pane, Yunita Sari
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Agriculture, Biological Sciences & Forestry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Relationship between SLC22A16 Gene Polymorphism and Hematological Toxicity in Breast Cancer Patients Receiving Doxorubicin-Based Chemotherapy KABAN, SRI MELINDA; Siti Syarifah; Pane, Yunita Sari; Tri Widyawati
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 1 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i1.18520

Abstract

ABSTRACT Background Drug transporter polymorphisms are widely associated with the risk of toxicity in many chemotherapy drugs in cancer. This paper aims to assess the relationship of polymorphisms of this transporter, namely SLC22A16, which are associated with side effects of Doxorubicin-based chemotherapy drugs, namely hematological toxicity (anemia, neutropenia, leukopenia and thrombocytopenia) in breast cancer patients. Method This cross-sectional study will be conducted by testing polymorphism using the ARMS PCR method, which will assess the distribution of AA, AG, and GG genotypes. Result  Most patient ages are under 50 years (55%), with overweight BMI (41,7%) and Batak ethnicity (43,3%). There is no relationship between SLC22A16 Gene Polymorphism and Hematological Toxicity in Breast Cancer Patients Receiving Doxorubicin-Based Chemotherapy
Antibiotic Use in Acne vulgaris: Pharmacological Perspectives and Emerging Resistance - A Brief Review Pane, Yunita Sari; Hasanah, Nur
International Journal of Ecophysiology Vol. 7 No. 2 (2025): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v7i2.21003

Abstract

Background: Acne vulgaris (AV) is a chronic inflammatory skin condition that frequently affects adolescents and young adults. It is characterized by comedones, papules, pustules, and nodules. The primary etiological factors include hyperkeratinization, excessive sebum production, colonization of Cutibacterium acnes (C. acnes), and an inflammatory immune response. Objective: This review discusses the pharmacological aspects and challenges associated with the use of antibiotics in AV treatment, particularly in the context of rising antibiotics resistance. Methods: This mini-review was conducted using data collected from online academic databases, including Google Scholar, ScienceDirect, and PubMed. From an initial pool of 60 articles related to AV treatment,antibiotic mechanism, and resistance patterns, 31 publications (1999 – 2024) were selected based on relevance and quality. Results: The pathophysiology of AV is multifactorial, involving sebaceous hyperactivity, follicular hyperkeratinization, microbial colonization, and immune-mediated inflammation. Topical drugs (e.q., tetracyclines) remain central in AV management. However, increased antibiotic resistance, especially by C. acnes has compromised their efficacy. Combining antibiotics with agents like benzoyl peroxide (BPO) or topical retinoids may help mitigate resistance. Alternative treatments, including isotretinoin, hormonal therapies, and physical modalities, provide additional therapeutic options. Conclusion: Antibiotic use in AV treatment requires careful pharmacological consideration, balancing efficacy, safety, cost, and resistance risk. To preserve long-term effectiveness, antibiotics should be combined with non-antibiotic agents and used for limited durations. Tailoring treatment based on disease severity, location, and patient preference is essential for optimal outcomes.
Co-Authors Kaban, Sri Melinda Nur Hasanah Siti Syarifah Tri Widyawati