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ASOSIASI PENYAKIT ALERGI ATOPI DENGAN IgG ANTI HELICOBACTER PYLORI PENELITIAN OBSERVASIONAL KASUS KONTROL ANALITIK DI UNIT RAWAT JALAN PENYAKIT DALAM RSU Dr SOETOMO SURABAYA PP, Agung; H, Novida; D, Fetarayani; A, Baskoro; G, Soegiarto; C, Effendi
journal of internal medicine Vol. 12, No. 3 September 2011
Publisher : journal of internal medicine

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Abstract

Approximately  20%  of  the  world  populations  suffer  from  IgE-mediated  allergic  diseases. Although  genetic  factors play an  important  role  in  the manifestation of allergic disease,  the existence of other  factors  such as  lifestyle  factors, socioeconomic factors and presence of oro-fecal infection including Helicobacter pylori infection also take a part. This is  based  on  the  hygiene  hypothesis  that  infections  in  childhood  can  reduce  allergic  diseases. We  conduct  a  study  to analyze negative association between allergic diseases with IgG anti Helicobacter pylori. This is a matched case control study involved 52 patients in Internal Medicine outpatient ward Dr. Soetomo Hospital Surabaya consisting of 26 patients with allergic diseases as a group of cases and 26 non-allergic patients as controls. Allergic disease was diagnosed by anamnesis, physical examination, and skin prick tests, whereas IgG anti Helicobacter pylori was measured using immune-chromatography  technique. We  found  in  the allergic group  there were 19 patient  (73.08%) with positive Helicobacter pylori and 7 patient (26.92%) with negative result.Whereas in control group there were 21 patient (80.77%) with positive Helicobacter pylori  result and 5 patient  (19.23%) were negative. Helicobacter pylori serology had protective effect  to allergic disease (OR 0.67, CI 95%). Was the conclusion, there is negative association between atopic allergic diseases with IgG anti Helicobacter pylori
ASOSIASI PENYAKIT ALERGI ATOPI ANAK DENGAN ATOPI ORANG TUA DAN FAKTOR LINGKUNGAN Syaiful Ludfi, Achmad; Agustina, Luki; D, Fetarayani; A, Baskoro; S, Gatot; Effendi, Chairul
journal of internal medicine Vol. 13, No. 1 Januari 2012
Publisher : journal of internal medicine

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Abstract

Atopic allergic disease related with genetic factor and environment. Some studies found parents and environment factorhave an important role on emerging of clinical manifestation. This study try to evaluated wheather atopic parents andenvironment can inuanced clinical manifestation of allergic disease in their children. This information is important foreducation and in intervention of treatment for patients with allergic disease. This study is an observasional analytic casecontrol study involved all student range from junior until high school level and their parents at Surabaya region. Datawas taken by quisioner, physical and Skin Prick Test (SPT). Statistical analyses using multivariat logistic regression test.Threehundreed forthy eight student was enrolled where 91 (26.1%) with positive SPT have atopic father 26 (56.9%) andatopic mother 25 (54.3%) on the other hand 249 student with negative SPT have atopic father 22 (43.1%) and atopicmother 21 (45.7%). Logistic regression test found that sequency number of birth and explanation dust mate assosiatedwith occurence of clinical manifestation of atopic allergic disease in children.