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All Journal journal of internal medicine Archive: Jurnal Pengabdian Kepada Masyarakat Folia Medica Indonesiana
Chairul Effendi
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Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Medicine & Pharmacology Neuroscience Public Health

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ASOSIASI PENYAKIT ALERGI ATOPI ANAK DENGAN ATOPI ORANG TUA DAN FAKTOR LINGKUNGAN Syaiful Ludfi, Achmad; Agustina, Luki; D, Fetarayani; A, Baskoro; S, Gatot; Effendi, Chairul
journal of internal medicine Vol. 13, No. 1 Januari 2012
Publisher : journal of internal medicine

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Atopic allergic disease related with genetic factor and environment. Some studies found parents and environment factorhave an important role on emerging of clinical manifestation. This study try to evaluated wheather atopic parents andenvironment can inuanced clinical manifestation of allergic disease in their children. This information is important foreducation and in intervention of treatment for patients with allergic disease. This study is an observasional analytic casecontrol study involved all student range from junior until high school level and their parents at Surabaya region. Datawas taken by quisioner, physical and Skin Prick Test (SPT). Statistical analyses using multivariat logistic regression test.Threehundreed forthy eight student was enrolled where 91 (26.1%) with positive SPT have atopic father 26 (56.9%) andatopic mother 25 (54.3%) on the other hand 249 student with negative SPT have atopic father 22 (43.1%) and atopicmother 21 (45.7%). Logistic regression test found that sequency number of birth and explanation dust mate assosiatedwith occurence of clinical manifestation of atopic allergic disease in children.
ASOSIASI ANTARA POLUSI UDARA DENGAN IgE TOTAL SERUM DAN TES FAAL PARU PADA POLISI LALU LINTAS Fahimi, Mukti; Dharma S, Bayu; Fetarayani, Deasy; Baskoro, Ari; Soegiarto, Gatot; Effendi, Chairul
journal of internal medicine Vol. 13, No. 1 Januari 2012
Publisher : journal of internal medicine

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Ambient air pollution often associated with allergic diseases and impaired respiratory function. Total serum IgE levels was  one  of  the  diagnostic  tools  to  establish  an  allergic  diseases while  lung  function  test was  standard  examination to establish alteration in lung function. Trafc police ofcers were often assigned on the highway is one of the mostvulnerable population against exposure to air pollution. Aim of this study isto know the association between air pollution on total serum IgE levels and lung function in trafc police ofcers compared to staff police ofcer as control.This is anobservational analysis study with cross sectional design.There were 60 police ofcers as a subject, divided in two groups.Thirty subjects as exposured groups and 30 subjects as control group. Air pollution was measured by Pollutant StandardIndex (PSI)/ Indeks Standar Pencemar Udara (ISPU) method. Independent  t-test and Mann-Whitney  test were used  to analyze differences between variabel. Spearman test was used to analyze correlation and strength between variabel.There were no signicant differences in total IgE serum levels between groups (p = 0.301). There were signicant differencesin FEV1 (%p) (p = 0.015), FVC (%p) (p = 0.000) and spyrometry result (p = 0.001). There was no signicant differencein FEV1/FVC ratio (p = 0.573). There were negative weak association between air polution and FEV1 (%p) (r = -0.298;p=0.021) and between air pollution and spyrometry result (r = -0.380; p = 0.003). There was negative moderate associationbetween air pollution and FVC (%p) (r = -0.409; p = 0.001). There was no association between air pollution and FEV1/FVC ratio (r = 0.058; p = 0.662). There was signicant association between air pollution and impaired respiratory functionbut there was no association between air pollution and total serum IgE levels.
Advokasi Guru Sekolah Mitra tentang Urgensi & Desain Pembelajaran untuk Penguatan Keterampilan Kolaborasi Siswa dalam Akselerasi Pemulihan Mutu Pembelajaran di Kota Kediri Primandiri, Poppy Rahmatika; Sucipto, Sucipto; Muzaki, Muhammad Najibullah; Jannah, Ro’ikatul; Setiani, Dila Elpin; Wati, Dewi Rossylia; Mustofa, Mohammad Annan Makruf; Faruq, Umar Al; Sukawati, Yunita; Fauzan, Ahmad; Setiawan, Heri; Sulastri, Sulastri; Qoyim, Ibnu; Effendi, Chairul; Kusanagi, Kanako N.; Afandi, Zainal; Santoso, Agus Muji
Archive: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 1 (2024): Desember 2024
Publisher : Asosiasi Pengelola Publikasi Ilmiah Perguruan Tinggi PGRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55506/arch.v4i1.154

Abstract

Latar Belakang: Ada kesenjangan kolaborasi siswa berkemampuan akademik tinggi dengan rendah. Pemahaman dan keterampilan guru dalam mendesain pembelajaran kolaboratif perlu dikuatkan. Tujuan: Menguatkan pemahaman dan keterampilan guru tentang desain pembelajaran yang menguatkan keterampilan kolaborasi siswa. Metode: Program advokasi dilaksanakan dengan model pembelajaran ODSIMED yang terdiri atas Observation, Design, Socialisasion, Implementation, Monitoring, Evaluation, dan Desemination bagi guru-guru sekolah mitra.  Hasil: Rata-rata skor pemahaman guru meningkat dengan kategori sedang (N Gain = 0,708).  Kesimpulan: Advokasi yang dilakukan efektif dalam meningkatkan pemahaman guru tentang keterampilan kolabroasi siswa.
Cetirizine suppression to skin prick test results in atopic allergy patients Soegiarto, Gatot; Kurnia, David; Effendi, Chairul; Konthen, Putu Gedhe
Folia Medica Indonesiana Vol. 53, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

This study was done to determine the suppression index of Cetirizine to the skin prick test results to obtain a correction constant or factor that can be used to assess the results of the skin prick test in patients who cannot stop the use of antihistamines (Cetirizine). This pre and post test study design clinical trial involved 22 atopic allergy patients who seek medical treatment at the Allergy and Immunology Outpatient Clinic Dr. Soetomo Hospital. Skin prick tests were done twice (SPT1 and SPT2) using house dust mite allergen extract to all study subjecs. The first (SPT1) were done after washout of all antihistamine for 1 week prior the test. All study subjects were then given Cetirizine 10 mg once daily for 5 days and on day 6 we performed the second test (SPT2). Cetirizine suppresion index and correction factor were calculated by comparing the wheal area of SPT1 and SPT2. All 22 study subjects (6 males and 16 females) were sensitized to house dust mite allergen. Mean serum total IgE levels were 176.42 + 352.5 IU/dL. Mean wheal area generated by the positive control (histamine 1 mg/mL) in SPT1 was 7.53 + 7.31 mm2, and in SPT2 was 1.08 + 1.46 mm2. Mean wheal area generated by house dust mite allergen in SPT1 was 43.57 + 36 mm2, and in SPT2 was 10.28 + 8.47 mm2. Cetirizine suppression index for positive controls (histamine 10 mg/mL) was 94.63 + 7.90% (p=0.000), while the Cetirizine suppression index for house dust mite allergen is 72.31 + 13.96% (p=0.000). There was no significant influence of serum total IgE levels to Cetirizine suppression index (p=0.381). The correction constant based on the calculation was 1.9. In conclusion, Cetirizine suppression index to the mean wheals area generated by house dust mite allergen was 72.31% and the correction constant was 1.9. In allergic patients who cannot stop their antihistamine drugs, Cetirizine 10 mg once daily can be used as a replacement and they still be able to undergo skin prick tests. The actual wheal diameter (or area) of the skin prick test results can be calculated by multiplying the measured wheal diameter (or area) under the Cetirizine administration with the correction constant.
Genetic and environmental factors as strong determinants of atopic allergic disease clinical manifestations in surabaya's school children Soegiarto, Gatot; Damayanti, Luki Agustina; Effendi, Chairul
Folia Medica Indonesiana Vol. 53, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

This case-control study was conducted to assess the relative role of genetic and environmental factors in determining the clinical manifestations of atopy allergy disease in school children, which is part of a large study of the prevalence of allergic diseases in school children in Surabaya. Using a simple multi-stage random sampling, 348 children from 5 elementary schools, 4 junior high schools, and 4 senior high schools in Surabaya were involved in the study. The subjects of the study along with her parents were guided to fill out the modified ISAAC questionnaire and underwent physical examination and skin prick test using 27 common allergen types found in the environment. For the analysis, 110 school children were randomly selected from the parent sample and included in the case group of 55 people (positive skin prick test against > 1 type of allergen), and the control group of 55 people (negative skin prick test). All genetic and environmental factors data were collected and analyzed. Most of the subjects had clinical manifestations of allergic rhinitis (66.36%), asthma (21.82%), food allergies (10.9%), and atopic dermatitis (6.36%). Complete models for multiple logistic regression analysis can only be performed for overall atopic disease and allergic rhinitis disease. The first birth order and exposure to home dust mites were the most significant clinical manifestations of atopy disease (OR 4.548, 95% CI: 1.813-11.410, p=0.01). Atopy status of the father was the only significant determinant factor for the manifestation of allergic rhinitis in the study subjects (OR 3.929; 95% CI: 1.143-13.052, p=0.03). Both genetic and environmental factors interacted and determined clinical manifestations of atopy allergy disease in school pupils. The father's genetic factors were more dominant than maternal genetic factors in determining the clinical manifestations of allergic rhinitis in offspring.
Co-Authors AA Sudharmawan, AA Achmad Syaiful Ludfi Afandi, Zainal Agus Muji Santoso Ahmad Fauzan Ari Baskoro Baskoro A Bayu Dharma S Damayanti, Luki Agustina Deasy Fetarayani Faruq, Umar Al Fetarayani D Gatot S Gatot Soegiarto Ibnu Qoyim, Ibnu Jannah, Ro’ikatul Konthen, Putu Gedhe Kurnia, David Kusanagi, Kanako N. Luki Agustina Muhammad Najibulloh Muzaki Mukti Fahimi Mustofa, Mohammad Annan Makruf Poppy Rahmatika Primandiri Setiani, Dila Elpin Sucipto Sucipto Sukawati, Yunita Sulastri Sulastri Wati, Dewi Rossylia