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Hutasoit, Regina M.
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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HUBUNGAN KECANDUAN PENGGUNAAN SMARTPHONE TERHADAP KUALITAS TIDUR MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS NUSA CENDANA TAHUN 2019 Firmansyah, Muhammad F.; Rante, Su Djie To; Hutasoit, Regina M.
Cendana Medical Journal Vol 8 No 1 (2020): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (191.61 KB) | DOI: 10.35508/cmj.v8i1.2664

Abstract

Jumlah pengguna smartphone di seluruh dunia diperkirakan akan terus tumbuh didominasi oleh usia 16-25 tahun yang secara luas banyak digunakan oleh mahasiswa tingkat perguruan tinggi. Mahasiswa dianggap rentan terhadap perkembangan teknologi karena dinamika perkembangan mereka dan kebebasan keluarga dari peran sosial dan harapan serta fitur yang ditawarkan sangat menarik, aplikasi yang lengkap serta mencerminkan gaya hidup yang metropolis.Ketergantungan menggunakan smartphone dapat menyebabkan memburuknya kualitas tidur seseorang salah satunya mahasiswa.Mahasiswa Fakultas Kedokteran adalah kelompok mahasiswa yang paling beresiko mengalami gangguan tidur. Hal ini mungkin disebabkan durasi dan intensitas pendidikan yang tinggi, banyaknya tugas, ujian serta tanggung jawab yang berat. Tujuan penelitian ini untuk mengetahui hubungan kecanduan penggunaan smartphoneterhadap kualitas tidur pada mahasiswa Fakultas Kedokteran Universitas Nusa Cendana tahun 2019. Metode penelitian ini merupakan penelitian analitikal observasional dengan rancangan cross sectional yang dilakukan pada mahasiswa preklinik Fakultas Kedokteran Universitas Nusa Cendana dengan cara pengisian kuesionerpengisian kuisoner Pittsburgh Sleep Quality Index (PSQI)dan kuisioner Smartphone Addiction Scale Short Version. (SAS-SV). Teknik pengambilan sampel menggunakan stratified random samplingdengan jumlah responden 75 orang yang memenuhi kriteria inklusi dan eksklusi. Penelitian dianalisis secara univariat, bivariat menggunakan uji chi-square. Hasil dari 75 responden, didapatkan hasil 45responden (60%) mengalami kecanduan penggunaan smartphonedan 30 responden (40%) tidak mengalami kecanduan smartphone. Dari 75 responden juga didapatkan60 responden(80%) memiliki kualitas tidur buruk dan 15 responden (20%) memiliki kualitas tidur baik. Hasil uji analisis bivariat pada penelitiaan ini diperoleh hasil p=0,018 (p<0,05). Kesimpulan penelitian ini terdapat hubungan yang signifikan antara kecanduan penggunaan smartphone terhadap kualitas tidur mahasiswa Fakultas Kedokteran Universitas Nusa Cendana tahun 2019
The Correlation between Local Culinary Eating Patterns With Symptoms of GERD in Bank Employees in Soe City, East Nusa Tenggara Liu, Cynthia Candra Dinawati; Hutasoit, Regina M.; Woda, Rahel Rara; Damanik, Efrisca M. Br.
Cendana Medical Journal Vol 13 No 1 (2025): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v13i1.16856

Abstract

Background: The prevalence of GERD has increased in all age groups with the highest incidence in the age group of 20 to 45 years. Bank employees are in the reproductive age group who have time demands of work, which require longer working hours with lifestyle changes and are at risk of developing GERD. Changes in eating patterns with spicy, sour and fatty foods such as corn bose, sei meat, sambal luat and tangerine soe if consumed frequently and in excessive amounts can cause heartburn and regurgitation complaints.Methods: This study uses an analytical observational research design with a cross sectional design conducted on bank employees in Soe City, East Nusa Tenggara using a local culinary diet questionnaire and a gastroesophageal reflux disease questionnaire (GERD-Q). Sampling using total sampling technique and obtained 99 research subjects who meet the inclusion criteria.Results: From the results of the contingency coefficient test, there is no relationship between local culinary eating patterns with GERD symptoms in bank employees in Soe City, East Nusa Tenggara.Conclusion: there is no correlation between local culinary eating patterns with GERD symptoms in bank employees in Soe City, East Nusa Tenggara.
Effect of Bay Leaf Extract (Syzygium polyanthum) on The Histopathological Appearance of Large Intestine of White Rats (Rattus novergicus) Induced by Ibuprofen Balbesi, Patrick David Altissimo; Damanik, Efrisca M. Br.; Koamesah, Sangguana Marthen Jacobus; Hutasoit, Regina M.
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.11206

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs), particularly Ibuprofen, are widely used for their analgesic and anti-inflammatory properties. However, irrational or prolonged use may lead to gastrointestinal injury, including NSAID-induced colitis, due to the inhibition of protective prostaglandins in the mucosa. Syzygium polyanthum (bay leaf) extract contains flavonoids, tannins, saponins, and essential oils with antioxidant and anti-inflammatory properties, making it a potential agent for improving mucosal damage in the colon. Objective to determine the effect of bay leaf (Syzygium polyanthum) extract on the histopathological features of the colon in Sprague Dawley rats induced with Ibuprofen. This study was an experimental laboratory research using a posttest-only control group design. Thirty male Sprague Histopathological assessment of the colon was performed across five fields of view using the scoring system. Data were analyzed using the Kruskal–Wallis test followed by the Mann–Whitney test. The positive control group exhibited severe mucosal damage with extensive epithelial erosion and inflammatory infiltration. The P1 group (50 mg/kgBW) showed moderate improvements, while the P2 group (150 mg/kgBW) demonstrated reduced inflammation and ulceration. The highest dose group, P3 (250 mg/kgBW), showed the most prominent mucosal recovery, with significantly milder lesions compared to other groups. Bay leaf extract significantly improves the histopathological condition of the colon in Ibuprofen-induced rats. Higher doses of the extract result in better mucosal healing and reduced tissue damage.
Effect of Bay Leaf Extract (Syzygium polyanthum) on Renal Histopathology in Ibuprofen-Induced White Rats (Rattus norvegicus) Butar, Angel Tiurma; Damanik, Efrisca M. Br.; Hutasoit, Regina M.; Dean, Muhajirin
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.11217

Abstract

Excessive use of nonsteroidal anti-inflammatory drugs (NSAIDs), especially ibuprofen, can cause Acute Kidney Injury (AKI) through oxidative stress and prostaglandin inhibition. Syzygium polyanthum leaves contain bioactive compounds such as flavonoids and tannins, which have antioxidant and antiinflammatory properties that may protect the kidneys. This study aimed to evaluate the nephroprotective effect and determine the optimal dose of ethanol extract of Syzygium polyanthum leaves on ibuprofeninduced renal damage in rats. Thirty-six male Sprague Dawley rats were divided into six groups: Negative Control (K-), Acute Positive Control (K+A), Recovery Positive Control (K+B), and three treatment groups (P1, P2, P3). Kidney damage was assessed using the EGTI scoring system (Endothelial, Glomerular, Tubular, Interstitial). Data were analyzed with the Kruskal-Wallis test followed by Dunn’s Post Hoc test. The analysis revealed significant differences in renal damage scores among the groups. The acute positive control group exhibited the highest level of renal injury. Among the treatment groups, the 150 mg/kgBW dose (P2) demonstrated the most optimal improvement, even exceeding spontaneous recovery. At the highest dose (P3), the protective effect did not increase and instead showed a tendency toward reduced efficacy, reflecting a hormetic phenomenon. The ethanol extract of Syzygium polyanthum leaves exerts significant nephroprotective effects against ibuprofen-induced histopathological damage to the renal epithelium, tubules, glomeruli, and interstitial tissue, with an optimal dose of 150 mg/kgBW.
Co-Authors Balbesi, Patrick David Altissimo Butar, Angel Tiurma Damanik, Efrisca M. Br. Firmansyah, Muhammad F. Koamesah, Sangguana Marthen Jacobus Liu, Cynthia Candra Dinawati Rante, Su Djie To Woda, Rahel Rara