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All Journal Jurnal Sains Teh dan Kina al Kimiya : Jurnal Ilmu Kimia dan Terapan
Suminar S. Achmadi
Departemen Kimia, FMIPA - IPB Kampus IPB Darmaga, Gedung Fakultas Peternakan, Bogor-16680
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Industrial & Manufacturing Engineering Mechanical Engineering

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Alkaloid profile of endophytic Diaporthe spp. from Cinchona calisaya Radiastuti, Nani; Rahayu, Gayuh; Okane, Izumi; Hidayat, Iman; Achmadi, Suminar S.
Jurnal Penelitian Teh dan Kina Vol 18, No 1 (2015)
Publisher : Research Institute for Tea and Cinchona

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (420.162 KB) | DOI: 10.22302/pptk.jur.jptk.v18i1.69

Abstract

Endophytic fungi have been known as potential source of bioactive compound, similar to their host.  This study was conducted to identify endophytic Diaporthe spp. isolated from Cinchona calisaya and to explore their potential in producing alkaloids, particularly quinine. A total of 39 strains of Diaporthe spp. were identified using ITS1-5.8S-ITS2 and EF1-α gene. Seventeen strains have species name and they represent eight species of Diaporthe i.e. D. cynaroidis, D. endophytica, D. ganjae, D. gardeniae, D. litchicola, D. phaseolorum, D. pseudomangiferae, and D. rhoina. The re­maining 22 strains represents 15 groups of unidentified Diaporthe sp. High performance liquid chromatography analyses of chloroform extract of 21-days old static cultures of all fungi in potato dextrose broth showed that these strains produce totally 82 different alkaloids. Each strain producedabout 2-38 different alkaloids. Sixteen out of 39 strains (41%), i.e. one strain each of D. endophytica, D. gar­deniae,  D. phaseolorum, and  D. pseudo­mangiferae, 2 strains of D. litchicola, and 10 strains of unidentified Diaporthe were able to produce quinine. The quinine concentration ranges from 1.1 mg/l to 155.2 mg/l. By using Jaccard’s similarity index 0.44 as the cutting score, UPGMA analyses of alkaloid profile of these strains shows that these strains forms 23 clusters. Alkaloid profile clustering does not support the phylogenetic grouping. This indicates that the alkaloid profile is strain dependent. Some potential strains should be further investigated for optimization of their quinine production.
EVALUATION OF MICROSPHERE OF POLY(LACTIC ACID) AS CELECOXIB CARRIER nurhayati, lany; Achmadi, Suminar S.; Sudaryanto, Sudaryanto
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 11, No 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.39310

Abstract

Celecoxib, cyclooxygenase-2 inhibitor approved for the management of rheumatism and osteoarthritis. Celecoxib is a Biopharmaceutics Classification System (BCS) class II compound whose oral bioavailability is highly limited owing to its poor aqueous solubility. Microencapsulation is very helpful to increase the solubility and slow the release of drugs. For the drugs of BCS Class-II, we use this technique which enables us to get more solubility and increase dissolution profile. The present study aims to reduce the drug’s negative effect and boost its bioavailability. Poly(lactic acid) (PLA) a biodegradable polymer microsphere that can be synthesized to encapsulate celecoxib, was prepared by solvent evaporation with chloroform were used. The characterized surface morphology, drug entrapment efficiency (DDE), and in vitro drug release. Morphology was studied by scanning electron microscopy (SEM), crystallinity was studied using an X-ray diffractometer (XRD), and drug release was spectrophotometer UV-Vis. The results were observed to indicate there were microspheres homogeneous in the distribution of celecoxib in the polymer matrix. Formulations indicated that DEE was between 55.80 and 70.70% with prolonged length microspheres in the 10-30 µm range. Study in vitro drug release, when placed in phosphate buffer (pH 7.4) containing 2% w/w Tween 80 solvent, there was an initial burst of drug release within the first two hours followed by constant drug release. The PLA microsphere can release the confined celecoxib gradually but does not follow a controlled diffusion mechanism, but rather a mechanism of expansion and erosion of the microsphere matrix.
EVALUATION OF MICROSPHERE OF POLY(LACTIC ACID) AS CELECOXIB CARRIER nurhayati, lany; Achmadi, Suminar S.; Sudaryanto, Sudaryanto
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol. 11 No. 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.39310

Abstract

Celecoxib, cyclooxygenase-2 inhibitor approved for the management of rheumatism and osteoarthritis. Celecoxib is a Biopharmaceutics Classification System (BCS) class II compound whose oral bioavailability is highly limited owing to its poor aqueous solubility. Microencapsulation is very helpful to increase the solubility and slow the release of drugs. For the drugs of BCS Class-II, we use this technique which enables us to get more solubility and increase dissolution profile. The present study aims to reduce the drug’s negative effect and boost its bioavailability. Poly(lactic acid) (PLA) a biodegradable polymer microsphere that can be synthesized to encapsulate celecoxib, was prepared by solvent evaporation with chloroform were used. The characterized surface morphology, drug entrapment efficiency (DDE), and in vitro drug release. Morphology was studied by scanning electron microscopy (SEM), crystallinity was studied using an X-ray diffractometer (XRD), and drug release was spectrophotometer UV-Vis. The results were observed to indicate there were microspheres homogeneous in the distribution of celecoxib in the polymer matrix. Formulations indicated that DEE was between 55.80 and 70.70% with prolonged length microspheres in the 10-30 µm range. Study in vitro drug release, when placed in phosphate buffer (pH 7.4) containing 2% w/w Tween 80 solvent, there was an initial burst of drug release within the first two hours followed by constant drug release. The PLA microsphere can release the confined celecoxib gradually but does not follow a controlled diffusion mechanism, but rather a mechanism of expansion and erosion of the microsphere matrix.
Co-Authors Gayuh Rahayu Iman Hidayat Izumi Okane, Izumi Lany Nurhayati Nani Radiastuti SUDARYANTO SUDARYANTO