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All Journal Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Buletin Farmatera
Putri, Sheila Dhiene
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Dentistry Health Professions Medicine & Pharmacology Neuroscience

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Journal : buletin farmatera

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Statins' Protective Effect For The Prevention Of Atrial Fibrillation Incidence After Coronary Artery Bypass Surgery Putri, Sheila Dhiene; Safri, Zainal
Buletin Farmatera Vol 7, No 2 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i2.9736

Abstract

Abstract: Atrial fibrillation (AF) after cardiac surgery is associated with an increased risk of complications, length of stay, and cost of care. Recent studies have demonstrated that statins have pleiotropic effects, including anti-inflammatory effects and preventing atrial fibrillation (AF). The objective of this study was to assess the efficacy of preoperative statin therapy in preventing AF after coronary artery bypass grafting (CABG). 53 patients underwent CABG in our hospital from February to August 2018. Patients were randomized into two groups to examine the effect of statins: those with atorvastatin 20 mg/day during the preoperative period (Atorvastatin group, n = 26) and those with rosuvastatin 10 mg/day (Rosuvastatin group, n = 27). The primary end-point is postoperative AF (POAF), with an overall incidence of postoperative AF of 11.3%. Postoperative AF incidence was insignificantly different between the atorvastatin and rosuvastatin groups (7.7% vs. 14.8%; p = 0,669). Our study indicated that atorvastatin had a similar protective effect to rosuvastatin in terms of post-operative AF prevention.Keywords: statin, post-operative AF
Work Shifts Affect Blood Pressure in Employees In Tegal Sari Mandala II Village Azizah, Siti Nur; Putri, Sheila Dhiene
Buletin Farmatera Vol 10, No 3 (2025)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v10i3.26297

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Abstract: Work shifts are a work system that is widely applied in various work sectors to increase productivity. However, the implementation of this system can hurt workers' health, especially in terms of blood pressure. Based on data from Tegal Sari Mandala II Village, Medan City, it was found that there was an increase in the prevalence of hypertension in workers who worked shifts compared to workers who had fixed working hours. Hypertension in shift workers can be caused by circadian rhythm disruptions, increased cortisol levels, irregular sleep patterns, and higher stress levels. This study aims to determine the effect of work shifts on blood pressure in employees in Tegal Sari Mandala II Village. This study uses an analytical design with a cross-sectional method. The sample consisted of 100 randomly selected employees. Data was collected through blood pressure measurements using a digital sphygmomanometer. Data analysis was carried out using the Chi-Square test with univariate and bivariate methods to measure the relationship between work shifts and hypertension. The results showed a significant relationship between work shifts and hypertension incidence (p=0.001). Shift workers are more prone to hypertension than non-shift workers, with the prevalence of grade 2 hypertension being 14 employees in the shift group. Shift workers have a higher risk of hypertension than non-shift workers. Therefore, structured occupational health interventions, good sleep patterns, and education about stress management are needed to reduce the risk of hypertension in shift workers.
HbA1c Levels Relate to the Severity of Atherosclerotic Lesions in Coronary Heart Disease Patients with Type 2 Diabetes Mellitus Rambe, Faridah Zulfa; Putri, Sheila Dhiene
Buletin Farmatera Vol 11, No 1 (2026)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v11i1.26797

Abstract

Abstract: Cardiovascular disease is one of the main causes of death in the world. In diabetes mellitus patients who experience hyperglycemia, the risk of coronary heart disease increases 2-4 times. Diabetes mellitus can be diagnosed using HbA1c examination. Coronary heart disease can be diagnosed using a coronary angiography examination, and the results are assessed using the vessel disease score. The design of this research is observational analytic with a cross-sectional approach. The research was conducted in October-December 2023 at RSU. Medan Hajj. The sample for this study was patients with coronary heart disease who had type 2 diabetes mellitus and underwent HbA1c examination and coronary angiography. Data analysis used the Mann-Whitney test. Based on data from RSU. Haji Medan obtained 23 samples, after 18 samples of multi-vessel disease were found with uncontrolled HbA1c levels, and then analysed with a result of 0.027 (p-value 0.05), which means there is a relationship between HbA1c levels and the severity of atherosclerotic lesions in disease patients. Coronary heart disease patients who have type 2 diabetes mellitus. There is a relationship between HbA1c levels and the severity of atherosclerotic lesions in coronary heart disease patients who have type 2 diabetes mellitus.
Co-Authors Ahmad Handayani BATUBARA, HEPPY JELITA SARI Mayfa, Rara Khairania Rambe, Faridah Zulfa Safri, Zainal Siti Nur Azizah, Siti Nur