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All Journal Jurnal Anestesiologi Indonesia Medical Journal of Indonesia Majalah Anestesia dan Critical Care Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia World Nutrition Journal The New Ropanasuri Journal of Surgery Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Neuroanestesi Indonesia Majalah Anestesia & Critical Care (MACC) Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute Jurnal Komplikasi Anestesi

Dita Aditianingsih

Departemen Anestesi Dan Terapi Intensif; Fakultas Kedokteran; Universitas Indonesia/ Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo; Jakarta

Author-ID : 219804

Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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The effect of balanced electrolyte solution versus normal saline in the prevention of hyperchloremic metabolic acidosis in diabetic ketoacidosis patients: a randomized controlled trial Aditianingsih, Dita; Djaja, Anne S.; George, Yohanes W.H.
Medical Journal of Indonesia Vol 26, No 2 (2017): June
Publisher : Faculty of Medicine Universitas Indonesia

Background: In resuscitation, normal saline could cause hyperchloremic metabolic acidosis, while balanced electrolyte solution is a crystalloid fluid resembling blood plasma with lower chloride content. This study compared the effect of normal saline and balanced electrolyte solution Ringerfundin (BES) as the resuscitation fluid in diabetic ketoacidosis (DKA) patients. Parameters applied in this study were standard base excess (SBE) as resuscitation’s result indicator and strong ion difference (SID) to measure chloride’s influence in developing hyperchloremic acidosis.Methods: A prospective, randomized, single blind controlled trial was conducted at the Emergency Department of Cipto Mangunkusumo Hospital. Thirty subjects with blood sugar >250 mg/dl, arterial pH <7.35 mg/dl, and positive blood ketone were randomly allocated to receive either normal saline (NS) or RingerfundinÒ (BES) as the standardized resuscitation protocol. Data analysis was performed using the unpaired T-test and the Mann Whitney test to compare the SBE and the SID means between both groups. Additional parameters were the level of consciousness, blood sugar level, vital signs, blood gas analysis, lactate, electrolyte, and blood ketone.Results: The mean SID in the BES group was significantly greater than the NS group of all measurements (p<0.05). The BES group had significantly higher mean SBE compared to the NS group at 18 hours (-4.88±5.69 vs -9.68±5.64; p=0.009), 24 hours (-3.99±4.27 vs -8.7±5.35; p=0.023), and 48 hours (-4.06±4.11 vs -7.01±5.46; p=0.009). BES resulted in non-significant higher delta SBE and SID than NS. Additional parameters were not different between both groups.Conclusion: This study showed that fluid resuscitation of DKA patients with BES resulted in slightly but not significantly higher mean actual SBE and SID than NS. suggesting that BES as an alternative fluid resuscitation to prevent hyperchloremic acidosis in diabetic ketoacidosis patients was not superior to NS.

Penanganan Hipoperfusi Pascaoperasi Esophagectomy Gastric Pull Up dengan AKI dan Malnutrisi Prasetyo, Eko Budi; Aditianingsih, Dita; George, Yohanes WH
Majalah Anestesia dan Critical Care Vol 32 No 1 (2014): Februari
Publisher : Perdatin Pusat

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Pasien bedah dengan risiko tinggi adalah mereka yang menjalani pembedahan dengan resiko tinggi untuk morbiditas dan mortalitas dengan angka kejadian mortalitas lebih besar dari 5% karena adanya penyakit penyerta atau derajat pembedahan. Penelitian terakhir di Inggris menunjukan bahwa pasien yang menjalani pembedahan beresiko tinggi mencakup 12,5 % dari jumlah total pasien yang masuk ke rumah sakit tetapi lebih dari 80% kematian, dengan kurang dari 15% dari mereka yang masuk ke Intensive Care Unit (ICU) paskaoperasi. Berikut ini adalah sebuah laporan kasus dari seorang laki-laki berusia 75 tahun yang menjalani esofagektomi gastric pull up yang disebabkan oleh kanker esophagus. Sebelum operasi, pasien mengalami malnutrisi berat dan hipoalbumin. Pasien mengalami komplikasi yang mencakup hipoperfusi, cedera ginjal akut dan pneumonia di ICU. Berfokus pada penatalaksanaan hipoperfusi, pasien menjalani hemodinamik goal directed therapy dengan target metabolik akhir yaitu normalisasi laktat, ScV02 dan tingkat PC02 gap. Pasien dipindahkan ke ruang rawat dalam keadaan baik pada hari ke-9. Kata Kunci: Esofagektomi, haemodynamic goal directed therapy, hipoperfusi, pasien bedah resiko tinggi Hypoperfusion Management Post Esophagoscopy Gastric Pull Up with Acute Kidney Injury and Malnutrition High-risk surgical patient is defined as a patient, undergoing surgery, who is at a high risk for morbidity and mortality with an expected mortality greater than 5% due to the coexisting diseases and/or the severity of surgery. A recent study in the United Kingdom demonstrated that patients undergoing high-risk general surgical procedures comprised only 12.5% of surgical admissions to hospitals but over 80% of deaths, with less than 15% of these high-risk patients admitted to the ICU postoperatively. This is a case report of 75 years old male who underwent esophagectomy gastric pull up due to esophageal cancer. Preoperatively patient suffered from severe malnutrition and hypoalbuminemia. In the ICU, patient some complications such as hypoperfusion, acute kidney injury and pneumonia. Focusing on hypoperfusion management, patient was treated using haemodynamic goal-directed therapy with end point metabolic target of normalize Lactate, ScVO2 and PCO2 gap levels. Patient was transferred to the ward in good condition on the 9th day. Key words: Esophagectomy, haemodynamic goal-directed therapy, high-risk surgical patient, hypoperfusion Lee N, Hamilton M, Rhodes A.Goal-directed therapy in high risk surgical patients : clinical review. Crit Care. 2009;13:231. Pearse RM, Harrison DA, James P. Identification and characterization of the high-risk surgical population in the United Kingdom. : research. Crit Care. 2006;10:R81 Boyd O, Jackson N. How is risk defined in high-risk surgical patient management? clinical review. Crit Care. 2005;9:390–6. Kirov MY, Kuzkov VV, Molnar Z. Perioperative haemodynamic therapy. Current opinion in Crit Care. 2010;16:384–92. Park DP, Welch CA, Harrison DA. Outcomes following oesophagectomy in patients with oesophageal cancer: a secondary analysis is the ICNARC case mix programme database. Crit Care. 2009;13(Suppl 2). Absi A, Adelstein DJ, Rice T. Esophageal cancer. Cleveland clinic. 2010 Agu. Wikipedia.org [internet]. Esophagectomy [diperbaharui 2014 Jan 29]. Tersedia dari:http://en.wikipedia.org Finks JF, Osborne NH, Birkmeyer JD. Trends in hospital volume and operative mortality for high-risk surgery. N Engl J Med. 2011;364:2128–37. Dalfino L, Giglio MT, Puntillo F.Hemodynamic goal-directed therapy and post operative infections: earlier is better. A systematic review and meta-analysis.Crit Care. 2011;15:R154. Pearse RM, Rhodes A, Grounds RM. How to optimize management of high-risk surgical patients: clinical review. Crit Care. 2004;8:503–7. Isabel M, Correia D, Waitzberg D. The impact of malnutrition on morbidity, mortality, length of hospital stay and cost evaluated through multivariate model analysis. Clinical Nutrition. 2003;22 (3):235–9. Ramanathan TS, Moppeti IK, Wenn R. POSSUM scoring for patients with fractured neck of femur. BJA. 2005;94(4):430–3. Riskprediction.org.uk [internet]. Risk prediction in surgery, Dalam; c1998–2003[diperbaharui 2010 Apr].Tersedia dari: http://www.riskprediction.org.uk Vincent JL, Moreno R. Clinical review: Scoring systems in the critically ill. Crit Care. 2010;14:207Hicereti licaescremum at, es arem dum ili sero, acibuturs culi iam faude nonocupimum stiam, Ti. Ipio egerbi patum sendum dem, quostis fec in tus vivit. Grat, puliacii conum more perit, simis fatquempor losuliisquam demena, nenatumusum stractortea me etortent? quod medetis.

Efek Perbedaan Volume Tidal Intraoperatif terhadap Rasio Pao2/Fio2 Pascaoperasi Abdominal Mayor Aditianingsih, Dita; Jefferson, Jefferson; Mandagi, Michael
Majalah Anestesia dan Critical Care Vol 34 No 2 (2016): Juni
Publisher : Perdatin Pusat

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Komplikasi paru pascaoperasi merupakan salah satu penyebab penting morbiditas dan mortalitas pascaoperasi yang berkaitan dengan anestesia dan pembedahan. Studi ini membandingkan volume tidal 6 mL/kgBB dan 10 mL/kgBB dengan menggunakan PEEP dan pengaruhnya terhadap komplikasi paru. Setelah mendapat persetujuan dari Komite Etik Penelitian Kesehatan FKUI/RSCM, dilakukan uji klinis acak terhadap 52 pasien operasi abdominal mayor elektif di Rumah Sakit Cipto Mangunkusumo pada bulan November 2014–April 2015. Subjek diacak dalam 2 kelompok, yaitu kelompok dengan volume tidal 6 mL/kg dengan PEEP 6 cmH2O dan volume tidal 10 mL/kg dengan PEEP 6 cmH2O. Keluaran primer adalah pemeriksaan fungsi paru menggunakan rasio PaO2/FiO2. Keluaran sekunder adalah komplikasi paru (pneumonia, atelektasis, ARDS, gagal napas), komplikasi ekstraparu (SIRS, sepsis, sepsis berat), dan mortalitas dalam 28 hari pascaoperatif. Tidak ditemukan perbedaan yang bermakna rasio PaO2/FiO2 antara kelompok VT-6 mL/kg dengan VT-10 mL/kg (p>0,05), baik pada awal operasi, akhir operasi, hari pertama pascaoperasi, dan hari kedua pascaoperasi. Tidak ada perbedaan bermakna pada semua keluaran sekunder diantara kedua kelompok. Simpulan, volume tidal 6 hingga 10 mL/kg dengan PEEP 6 cmH2O aman untuk dipakai pada pasien yang menjalani operasi abdominal mayor. Kata kunci: Operasi abdominal mayor, pemeriksaan fungsi paru, ventilasi mekanis, volume tidal The Effect of Intraoperative Tidal Volume Difference against Postoperative PaO2/FiO2 Ratio for Patients undergoing Major Abdominal SurgeryPostoperative pulmonary complications are closely related to postoperative morbidity and mortality associated with anesthesia and surgery. Mechanical ventilation setting affects postoperative pulmonary complications. This study aimed to compare the effect between tidal volume of 6 mL/kgBW and 10 mL/kgBW with PEEP and its effect on pulmonary complications. After approval from Ethics Committee Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo (RSCM) Hospital, a randomized clinical trial was done on 52 elective major abdominal surgery patients at RSCM Hospital from November 2014 to April 2015. Subjects were randomized into two groups: the group receiving tidal volume 6 mL/kgBW with PEEP 6 cmH2O (VT-6 group) and the group receiving tidal volume of 10 mL/kgBW with PEEP 6 cmH2O (VT-10 group). The primary output was the assessment of pulmonary function using the ratio of PaO2/FiO2. Secondary outputs were pulmonary complications (pneumonia, atelectasis, ARDS, respiratory failure), extrapulmonary complications (SIRS, sepsis, severe sepsis), and mortality within 28 days. Both groups showed similar baseline characteristics. There was no significant PaO2/FiO2 ratio differences between both groups (p>0,05) at the beginning of surgery, at the end of surgery, at the first postoperative day, and the second postoperative day. There was no significant difference in all secondary outcomes between both groups. The use of tidal volume of 6 to 10 mL/kg with PEEP 6 cmH2O was considered safe for patients undergoing major abdominal surgery. Key words: Major abdominal surgery, mechanical ventilation, pulmonary function tests, tidal volume

Survival Rate of Critically Ill Coronavirus Disease 2019 Patients on Tracheostomy in Indonesia Ramdhani, Aris; Aditianingsih, Dita; Zahra, Raihanita; Putra, Muhammad A; Soeharto, Wuryantoro; Kwa, Melvin D.B.
The New Ropanasuri Journal of Surgery
Publisher : UI Scholars Hub

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Introduction. During COVID-19 global pandemic, tracheostomy is often performed on critically ill COVID-19 patients. There is no available data on the survival rate of critically ill COVID-19 patients on tracheostomy in Indonesia. This study aimed to find the survival rate of critically ill COVID-19 patients on tracheostomy in Indonesia. Methods. A descriptive survival analysis study enrolled critically ill COVID-19 patients in RSUI who underwent a tracheostomy procedure. Baseline data, including clinical characteristics and laboratory findings before tracheostomy, were recorded. Survival analysis was conducted using the Kaplan-Meier plot. Results. Forty-two subjects were enrolled in the study: 25 males (59.5%) and 17 females (40.5%). The median age was 57 (26 – 72) years. Subjects with diabetes mellitus or hypertension were 78.6% and 78.6% with BMI >25 kg/m2. The mean duration of intubation was 16.24 ±7.62 days, the median duration of tracheostomy before the outcome was 8 (0 – 53) days. There were 9.5% of subjects survived and were discharged. The median survival time was 8 (0 – 53). In the first 15 days after tracheostomy procedures, those who were deceased were 75% of the subjects. Conclusion. In this study, the survival rate of critically ill COVID-19 patients on tracheostomy remains low. Another study to evaluate the cause of the low survival rate of critically ill patients with COVID-19 on tracheostomy is required.

The Relationship Between Hyperglycemia Status and High Gastric Residual Volume Status in Adult ICU Patients Pittara Pansawira; Luciana Budiati Sutanto; Dita Aditianingsih
World Nutrition Journal Vol. 1 No. 1 (2017)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V01i1.0003

Henti Jantung Pasca Koreksi Berlebih Natrium Bikarbonat pada Pasien Ketoasidosis Diabetikum di Bangsal Resusitasi Rumah Sakit Pusat Nasional Cipto Mangunkusumo Anne Suwan Djaja; Dita Aditianingsih; George Yohannes
JAI (Jurnal Anestesiologi Indonesia) Vol 6, No 2 (2014): Jurnal Anestesiologi Indonesia
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jai.v6i2.7724

Latar Belakang: Infus sodium bikarbonat diberikan kepada pasien asidosis dengan pH kurang dari 7,1. Asidosis mematikan / letal, yang berarti pH kurang dari 7,1, akan menonaktifkan enzim dan modulator lain dalam tubuh dan oleh karena itu harus dikoreksi.Kasus: Seorang wanita berusia 51 tahun dirawat di rumah sakit dengan keluhanutama nyeri dada atipikal sejak satu hari yang lalu. Dia memiliki riwayat diabetes mellitus tipe 2, dikontrol dengan metformine 3x500 mg, penyakit ginjal kronis dengan urin produksi 0,6 cc / kg / jam. Riwayat penurunan kesadaran, penyakit serebrovaskular, dan infark miokard disangkal. Saat masuk bangsal perawatan, ia tampak sakit parah, dengan tekanan darah 110/70 mmHg, nadi 65 kali per menit, dan frekuensi napas 32 kali per menit.Ringkasan: Hanya tiga variabel independen yang bisa merubah pH, yaitu ion-ion kuat (SID/ Strong ion Differences), pCO2, dan ATOT. Mekanisme peran natrium bikarbonat dalam meningkatkan pH adalah dengan meningkatkan tingkat SID/ Strong Ion Differences. Pemberian berlebih dari natrium bikarbonat meningkatkan tingkat pH cepat. Itu membuat oksigen tidak dapat memisahkan dari hemoglobin, menyebabkan hipoksia seluler, dan menginduksi kematian sel.

Tatalaksana Pasien Sepsis dengan Sindroma Cushing Iatrogenik Eksogen Ardiyan Ardiyan; Dita Aditianingsih
JAI (Jurnal Anestesiologi Indonesia) Vol 10, No 1 (2018): Jurnal Anestesiologi Indonesia
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif

Sepsis adalah disfungsi organ mengancam nyawa akibat ketidakseimbangan respon tubuh terhadap infeksi. Kerentanan terhadap infeksi berat pada penderita penyakit autoimun maupun immunokompromais disebabkan konsumsi obat dan terapi yang dijalani. Pemberian atau penggunaan kortikosteroid dosis tinggi dan lama seperti hiperkortisolisme atau sindrom Cushing meningkatkan kerentanan terhadap infeksi Pasien imunokompromis berisiko tinggi mengalami infeksi patogen serta infeksi oportunistik oleh mikroorganisme virulen. Infeksi merupakan faktor predisposisi terjadinya peningkatan respon kompromi sistemik tubuh dalam kondisi sepsis dan syok sepsis. Kasus ini melaporkan seorang pasien berusia 24 tahun dengan sepsis akibat pneumonia yang diperberat oleh sindroma Cushing iatrogenic akibat steroid yang dikonsumsi dalam waktu lama, menyebabkan sulitnya perawatan serta prognosis yang buruk.

Peran Plasmafaresis pada Terapi Pasien Sepsis dengan Myasthenia Gravis Ahmad Imron; Dita Aditianingsih; Yohanes W George
JAI (Jurnal Anestesiologi Indonesia) Vol 5, No 3 (2013): Jurnal Anestesiologi Indonesia
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif

Pendahuluan : Plasmapheresis berpotensi untuk menghilangkan mediator berbahaya atau beracun dari sirkulasi . Plasmapheresis telah menunjukkan peningkatan keluaran yang bermakna pada penyakit autoimun . Kemanjuran theurapetic dan keamanan plasmapheresis dalam pengobatan pasien di sepsis berat dan syok septik telah dipelajari .Kasus : Seorang perempuan berusia 18 tahun didiagnosis dengan gagal nafas karena myasthenia gravis dan sepsis berat akibat pneumonia . Dia dirujuk dari rumah sakit lain setelah kegagalan obat antikolinesterase untuk mengobati gejala dari myasthenia gravis. x foto thorax menunjukkan infiltrat di paru-paru kanan paracardial dan basal . Terapi yang diberikan selama di ICU adalah antibiotik , obat-obatan suportif, dan plasmapheresis dilakukan selama 4 kali . Setelah antibiotik yang sesuai diberikan dan plasmapheresis selesai, pasien menunjukkan perbaikan kekuatan otot. Pasien berhasil disapih dari ventilator pada hari ke - 9 , dan kembali ke bangsal di hari - 10 .Ringkasan : Plasmapheresis memainkan peran penting dalam pengobatan myasthenia gravis dengan sepsis . Plasmapheresis digunakan untuk menghapus berbagai factor pemicu dalam plasma , seperti antibodi , imunoglobulin abnormal dan kompleks imun dalam sirkulasi

The Comparison of High Flow Nasal Cannula Oxygen and Conventional Oxygen Therapy on Early Effect Hemodynamic Indicators in Post â€“ Upper Abdominal Surgery Patients: A Pilot Study Luki Sumaratih; Rudyanto Soedono; Dita Aditianingsih
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 3 No. 4 (2019): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v3i4.99

Background The effect of high-flow nasal cannula (HFNC) on hemodynamic data of the patients is still unknown. This was a pilot study to evaluate the effect of HFNC and conventional oxygen therapy (COT) on post-upper abdominal surgery. Methods This was an open-label randomized controlled trial (RCT) at tertiary hospital between February-June 2019. Inclusion criteria were ASA III, aged 18-65 years, BMI 18,5-29 kg/m2. Exclusion criteria were patients with unstable hemodynamic with vasopressors, general oedema, and uncooperative. Thirty patients were recruited and divided into HFNC group (n=15) and COT group (n=15). Hemodynamic parameters were recorded using the bedside monitor (heart rate, respiratory rate, and mean arterial pressure) as well as the electrical cardiometry using ICONÂ® measurements (stroke volume index, cardiac index and systemic vascular resistance index); laboratory parameters were ScVO2 and lactate serum. Data were collected at 0, 30 and 60 minutes post-extubation. Results The General Linear Model (GLM) tests on clinical parameters (HR, RR and MAP) were P= 0.20; P=0.72; P = 0.18, ICONÂ® parameters (SVI, CI and SVRI) were P= 0.02;P =0.64; P =0.64 meanwhile ScVO2 and lactate were P = 0.35 and P = 0.22. Despite those results, at some period of measurements there were a tendency of a better outcomes of most parameters for the HFNC group. Conclusion According to the results, the only statistically significant outcome was SVI (P =0.02) after the analysis between those two groups. However, the HFNC group showed a clinically improvement of the other outcomes among post-upper abdominal surgery patients. Keywords High flow nasal cannula, conventional oxygen therapy, haemodynamic, abdominal surgery

Efek perbedaan Volume Tidal Ventilasi Mekanik Selama Operasi terhadap Rasio PaO2/FiO2 Pascakraniotomi Elektif Dita Aditianingsih; Rudyanto Sedono; Yoshua Baktiar
Jurnal Neuroanestesi Indonesia Vol 5, No 3 (2016)
Publisher : https://snacc.org/wp-content/uploads/2019/fall/Intl-news3.html

Latar Belakang: Kraniotomi elektif memiliki insidens komplikasi paru pascaoperasi (25%) dan mortalitas (10%) yang tinggi; insiden ini lebih rendah pada pemakaian volume tidal rendah sebagai teknik proteksi paru. Penelitian ini meneliti efek volume tidal 6 mL/kg dan 10 mL/kg terhadap rasio PaO2/FiO2(sebagai parameter keparahan cedera paru) pascaoperasi pada kraniotomi elektif.Subjek dan Metode: Setelah mendapat izin Komite Etik FKUI/Rumah Sakit Cipto Mangukusumo dan konsen pasien, dilakukan uji klinis acak pada 52 pasien kraniotomi elektif yang dirandomisasi ke dalam 2 kelompok: ventilasi mekanik selama operasi dengan volume tidal 6 mL/kg (VT–6) atau 10 mL/kg (VT–10), lalu dilakukan analisis gas darah.Hasil: Rasio PaO2/FiO2 kelompok VT-6 dan VT–10 secara berurutan: pada 1 jam pascainduksi 413,7 ± 113,4 mmHg dan 401,5 ± 106,3 mmHg (p0.05); pada akhir operasi, 466,6 ± 94,6 mmHg dan 471,1 ± 89,0 mmHg (p0.05), pada 24 jam pascainduksi, 418,8 ± 108,8 mmHg dan 448,5 ± 119,6 mmHg (p0.05); pada 48 jam pascainduksi, 414,9 ± 88,1 mmHg dan 402,5 ± 100,7 mmHg (p0.05 ). Tidak ada perbedaan signifikan insiden mortalitas dan komplikasi paru dan ekstraparu diantara dua kelompok.Simpulan: Tidak ada perbedaan signifikan antara volume tidal 6 ml/kg dan 10 ml/kg terhadap ratio PaO2/FiO2 pada pasien kraniotomi elektif.The Effect of Different Tidal Volume against Postoperative PaO2/FiO2 Ratio in Elective Craniotomy PatientsBackground: Elective craniotomy is associated with a high incidence of postoperative pulmonary complications/PPC (25%) and mortality (10%); in which these incidence went down with the administration of low tidal volume. This study investigated the effect of low tidal volume in intraoperative PaO2/FiO2 ratio in elective craniotomy patients.Subject and Methods: After approval from Ethics Committee Faculty of Medicine Universitas Indonesia, Ciptomangunkusumo Hospital and consent from patients,a randomized controlled trialwas done to 52 elective craniotomy patients. Subjects were ventilated with tidal volume 6 mL/kg (VT–6) or 10 mL/kg (VT–10) intraoperatively, then blood gas analyses wereperformed.Results: PaO2/FiO2 ratio of VT–6 and VT–10 respectively: at 1 hour postinduction, 413.7 ± 113.4 mmHg and 401.5 ± 106.3 mmHg (p0.05); at end of surgery, 466.6 ± 94.6 mmHg and 471.1 ± 89.0 mmHg (p0.05); at 24 hours postinduction, 418.8 ± 108.8 and 448.5± 119.6 mmHg (p0.05); at 48 hours postinduction, 414.9 ± 88.1 mmHg and 402.5 ± 100.7 mmHg (p0.05). There were no significant differences on mortality, lung and extralung complications observed between both groupsConclusions: There were no significant difference between tidal volume 6 ml/kg and 10 ml/kg against intraoperative PaO2/FiO2 ratio in elective craniotomy patients.

Co-Authors Achmad Noerkhaerin Putra Ahmad Imron Anindhita, Bintari Anne Suwan Djaja Ardiyan Ardiyan Baktiar, Yoshua Bob Firman Djaja, Anne S. George Yohannes George, Yohanes W.H. George, Yohanes WH Hafidz, Noor Indro Mulyono Jefferson, Jefferson Kwa, Melvin D.B. Luciana Budiati Sutanto Luki Sumaratih Mandagi, Michael Manggala, Sidharta Kusuma Nurul Ratna Mutu Manikam Palu, Raphael Putra Pittara Pansawira Putra, Muhammad A Ramdhani, Aris Rudyanto Sedono Rudyanto Sedono, Rudyanto Rudyanto Soedono Sania, Nina Singal, Anna Maurina Soeharto, Wuryantoro Sudarsono Sugiarto, Adhrie Wahyu Ika Wardhani Yohanes W George Yoshua Baktiar Yulia Rosa Saharman Zahra, Raihanita

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