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Bicornis unicollis uterus as a risk factor of preterm birth: A case of young woman with multiple premature births Hasanuddin, Hasanuddin; Maharani, Cut R.; Nora, Hilwah; Roziana, Roziana; Aditya, Rizka; Dewi, Tgk. Puspa; Qadri, Sofyan
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.229

Abstract

Bicornis unicollis uterus is a rare congenital uterine abnormality that occurs due to the failure of Mullerian duct fusion early in the development of the female internal genitalia system. In this case report, we present a woman with bicornis unicollis uterus who had preterm birth. A 30-year-old female patient with two caesarean sections history with premature babies was presented to the hospital with a complaint of regular contractions for twelve hours in her third preterm pregnancy. The patient has no particular symptoms besides acute abdominal pain. The ultrasonography examination indicated a uterus didelphys with breech presentation fetus. Due to the patient’s caesarean history and the fetal presentation, an emergency caesarean section was decided and performed. It was found that the gravid uterus was on the left and the baby was subsequently delivered with a complete placenta. Postoperative condition of the patient was shown to be stable while the baby underwent an intensive care at the neonatal intensive care unit. This case report highlights that early diagnosis in this rare case is critical since bicornis unicollis uterus are mostly asymptomatic. Caesarean section was chosen in the present case based on consideration of the fetal and maternal clinical conditions.
Dandy Walker Malformation Prenatal Diagnosis and Postnatal Outcome in Multigravida: A rare Case Mustaqin, Mustaqin; Utami, Niken Asri; Dewi, Tgk. Puspa; Fandika, Bayu Azizka Putra
Journal of Society Medicine Vol. 4 No. 6 (2025): June
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i6.214

Abstract

Introduction: Dandy Walker malformation (DWM) is a rare congenital anomaly characterized by cerebellar vermis hypoplasia, posterior fossa expansion, and fourth ventricle enlargement, often associated with hydrocephalus and chromosomal abnormalities like Trisomy 18 (Edwards syndrome). This case report describes the prenatal diagnosis and postnatal outcome of DWM in a multigravida patient. Case: A 43-year-old multigravida woman at 29–30 weeks’ gestation presented to Dr. Zainoel Abidin General Hospital with suspected fetal anomalies. Obstetric examination revealed a transverse fundal height of 23 cm, estimated fetal weight of 1,500 grams, fetal heart rate of 140 beats/min, and maternal hypertension (160/90 mmHg). Ultrasound identified DWM (absent cerebellar vermis, enlarged fourth ventricle), bilateral hydronephrosis, and undescended testes. The patient had a history of poorly controlled hypertension and reported owning a cat for one year but denied alcohol or smoking. Following counseling, pregnancy termination was performed, resulting in the delivery of a 1,400-gram male infant (length: 36 cm, Apgar score: 4–5). Postnatal phenotypic examination revealed undescended testes, low-set ears, overlapping digits, respiratory distress, small stature, and hypotonia. Karyotyping confirmed Trisomy 18. Conclusion: This case underscores the importance of prenatal ultrasound in detecting DWM and associated anomalies, enabling informed decision-making. The coexistence of DWM and Trisomy 18 highlights the need for genetic testing in such cases. Despite termination, the poor postnatal outcome reflects the severe prognosis of Trisomy 18. This report contributes to the limited literature on DWM in multigravida patients.
Cortisol and pregnancy-related anxiety in relation to preeclampsia among third-trimester pregnant women: A case–control study from Aceh, Indonesia Hezron, Teuku M.; Dewi, Tgk. Puspa; Septivera, Yusra; Rajuddin, Rajuddin; Utami, Niken A.
Narra J Vol. 5 No. 3 (2025): December 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i3.2985

Abstract

Despite extensive research, the interplay between hormonal stress markers and pregnancy-specific anxiety in the pathogenesis of preeclampsia remains insufficiently understood. This study aimed to analyze the simultaneous relationships between serum cortisol levels, pregnancy-related anxiety, and the occurrence of preeclampsia among third-trimester pregnant women. A case–control study was conducted at three hospitals in Banda Aceh, Indonesia, involving third-trimester pregnant women. Serum cortisol concentrations were measured using an immunoassay, and anxiety levels were assessed with the validated Pregnancy Related Anxiety Questionnaire (PRAQ). Preeclampsia diagnosis followed standard clinical and laboratory criteria. Associations between cortisol levels (categorized into high and normal) and PRAQ scores (classified as high and low–moderate) with preeclampsia were evaluated using the Chi-squared test, and crude odds ratios (OR) with 95% confidence intervals (95%CI). The Spearman’s correlation was used to determine the correlation between cortisol levels and PRAG scores. A total of 66 pregnant women were included in the final analysis (33 with preeclampsia and 33 with normal pregnancy). Women with high serum cortisol levels had a markedly greater likelihood of developing preeclampsia compared with those with normal cortisol levels (odds ratio (OR)=34.00; 95% confidence interval (95%CI): 4.93–234.46). Similarly, women with high pregnancy-related anxiety exhibited a significantly elevated risk of preeclampsia (OR=16.71; 95%CI: 4.95–56.39). No significant correlation was observed between cortisol levels and PRAQ scores in both groups (preeclampsia: r=-0.041, p=0.821; normal pregnancy: r=0.278, p=0.117). In conclusion, elevated serum cortisol and high pregnancy-related anxiety are independently associated with preeclampsia, although not directly correlated with each other. These findings highlight the potential of dual screening for cortisol and pregnancy-specific anxiety as an innovative approach for early identification of women at high risk of preeclampsia.