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All Journal Majalah Kedokteran Bandung Bali Dermatology and Venereology Journal Cermin Dunia Kedokteran Cermin Dunia Kedokteran
Aviana, Felicia
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Steroid-induced diabetes mellitus in pemphigus vulgaris patient at Bali Mandara Hospital: a case report Aviana, Felicia; Birawan, I Made
Bali Dermatology and Venereology Journal Vol 4, No 2 (2021)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v4i2.43

Abstract

Background: Pemphigus vulgaris (PV) is a blistering autoimmune disease of the skin and mucous membranes defined histologically by intraepidermal blister due to acantholysis. Systemic corticosteroids and immunosuppressive agents had greatly improved the prognosis of pemphigus. However, steroid use often leads to metabolic complications, such as diabetes mellitus. This case report describes steroid-induced diabetes mellitus in PV, where the side effect of long-term high dosages steroid used and the method to manage it can be used as a study case.Case report: A 31-year-old man complained of new blisters from almost the entire body. He had a history of PV 1 year ago and no history of diabetes mellitus in the patient or family. He had a medication history of methylprednisolone 8 mg every 8 hours. Dermatological status showed erythema macules, extensive erosion almost on the entire body, the Nikolsky sign (+), and the Asboe-Hansen sign (+). Blood laboratory result: random blood glucose 451 mg/dl, HbA1c 12.3%.  Histopathological examination: suprabasal blister, in which the basal cells still attached to the basement membrane show a “tombstone” appearance. The diagnosis was steroid-induced diabetes in pemphigus vulgaris. He was treated with steroids and insulin.Conclusion: Steroid use in PV treatment can lead to metabolic complications, such as diabetes mellitus. Regularly monitoring is needed to prevent complications due to steroid use.
Profil Penderita Morbus Hansen di Poliklinik Kulit dan Kelamin RSUD Bali Mandara Januari 2018-Desember 2020 Aviana, Felicia; Birawan, I Made; Sutrini, Ni Nyoman Ayu
Cermin Dunia Kedokteran Vol 49, No 2 (2022): Infeksi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (91.316 KB) | DOI: 10.55175/cdk.v49i2.1725

Abstract

Morbus Hansen (MH) merupakan salah satu penyakit terabaikan dan masih sering dijumpai di negara tropis dan subtropis, termasuk di Indonesia yang menduduki peringkat ketiga di dunia. Penelitian deskriptif retrospektif dilakukan untuk mengetahui profil penderita MH di PoliklinikKulit dan Kelamin RSUD Bali Mandara periode Januari 2018-Desember 2020. Didapatkan 55 penderita MH dengan 492 (1,6%) kunjungan dari 30587 total kunjungan; terdiri dari 39 (71%) laki-laki dan 16 (29%) perempuan, terbanyak dari kelompok usia 25-44 tahun (45,5%). Berdasarkan tipe MH, didapatkan tipe multibasiler (MB) sebesar 92,7%. Berdasarkan reaksi MH, didapatkan 14,5% pasien dengan reaksi erythema nodosum leprosum (ENL), tidak didapatkan pasien reaksi reversal. Mayoritas penderita MH di Poliklinik Kulit dan Kelamin RSUD Bali Mandara periode Januari 2018-Desember 2020 adalah laki-laki, kelompok usia 25-44 tahun, tipe multibasiler dengan reaksi erythema nodosum leprosum (ENL).
Efek Samping Steroid Sistemik pada Terapi Pemgus Vulgaris Aviana, Felicia; Birawan, I Made
Cermin Dunia Kedokteran Vol 48, No 9 (2021): Nyeri Neuropatik
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.257 KB) | DOI: 10.55175/cdk.v48i9.1488

Abstract

Pemfigus vulgaris (PV) adalah penyakit autoimun vesikobulosa pada kulit dan membran mukosa yang secara histologi ditandai bula intraepidermal yang disebabkan oleh akantolisis. Steroid sistemik merupakan terapi utama PV. Artikel ini membahas efek samping terapi steroid parenteral pada pemfigus vulgaris.Pemphigus Vulgaris (PV) is an autoimmune blistering disease of skin and mucous membranes, histologically defined by intraepidermal blister due to acantholysis. Systemic steroid is the first-line treatment in PV. This article briefly discussedthe adverse effect of parenteral steroid in the treatment of pemphigus vulgaris.
Microbial Diversity and Antimicrobial Susceptibility from Wound Dehiscence Isolates in an Indonesian Tertiary Referral Hospital Aviana, Felicia; Fatmawati, Ni Nengah Dwi
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3422

Abstract

Healthcare-associated infections (HAIs) remain a critical issue for public health in Indonesia, with wound dehiscence associated with surgical site infections (SSIs) being one of them. Globally, SSIs are known as the most common postoperative complications with a heightened prevalence, particularly in low to middle-income countries. With its retrospective and descriptive design, this study aimed to illustrate the microbial patterns identified in Prof. Dr. I.G.N.G. Ngoerah General Hospital from 12 January 2020 to 12 December 2022. The study includes all patients who underwent surgery and were subsequently diagnosed with wound dehiscence and SSIs. Specimens were collected from patients and submitted to the Microbiology Laboratory at the hospital above. Bacterial identification and susceptibility testing to antimicrobials were performed using the Vitek 2 Compact System (bioMerieux, Marcy l'Etoile, France). Patient information was sourced from medical records. Out of 172 samples, 151 (87.8%) yielded positive cultures. Among these, 151 (87.8%) were found to be positive. Gram-negative bacteria were found to be most prevalent, with Escherichia coli (20.2%) and Pseudomonas aeruginosa (19.6%) being the most frequently isolated bacteria. The bacteria isolated were mostly susceptible to amikacin (72.1%), followed closely by meropenem (71.4%). This information could contribute to the development of an empirical antibiotic therapy protocol for wound dehiscence or SSI cases in this local context.
Efek Samping Steroid Sistemik pada Terapi Pemvigus Vulgaris Aviana, Felicia; Birawan, I Made
Cermin Dunia Kedokteran Vol 48 No 9 (2021): Neurologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i9.117

Abstract

Pemfigus vulgaris (PV) adalah penyakit autoimun vesikobulosa pada kulit dan membran mukosa yang secara histologi ditandai bula intraepidermal yang disebabkan oleh akantolisis. Steroid sistemik merupakan terapi utama PV. Artikel ini membahas efek samping terapi steroid parenteral pada pemfigus vulgaris. Pemphigus Vulgaris (PV) is an autoimmune blistering disease of skin and mucous membranes, histologically defined by intraepidermal blister due to acantholysis. Systemic steroid is the first-line treatment in PV. This article briefly discussedthe adverse effect of parenteral steroid in the treatment of pemphigus vulgaris.
Profil Penderita Morbus Hansen di Poliklinik Kulit dan Kelamin RSUD Bali Mandara Januari 2018-Desember 2020 Aviana, Felicia; Birawan, I Made; Sutrini, Ni Nyoman Ayu
Cermin Dunia Kedokteran Vol 49 No 2 (2022): Infeksi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i2.192

Abstract

Morbus Hansen (MH) merupakan salah satu penyakit terabaikan dan masih sering dijumpai di negara tropis dan subtropis, termasuk di Indonesia yang menduduki peringkat ketiga di dunia. Penelitian deskriptif retrospektif dilakukan untuk mengetahui profil penderita MH di Poliklinik Kulit dan Kelamin RSUD Bali Mandara periode Januari 2018-Desember 2020. Didapatkan 55 penderita MH dengan 492 (1,6%) kunjungan dari 30587 total kunjungan; terdiri dari 39 (71%) laki-laki dan 16 (29%) perempuan, terbanyak dari kelompok usia 25-44 tahun (45,5%). Berdasarkan tipe MH, didapatkan tipe multibasiler (MB) sebesar 92,7%. Berdasarkan reaksi MH, didapatkan 14,5% pasien dengan reaksi erythema nodosum leprosum (ENL), tidak didapatkan pasien reaksi reversal. Mayoritas penderita MH di Poliklinik Kulit dan Kelamin RSUD Bali Mandara periode Januari 2018-Desember 2020 adalah laki-laki, kelompok usia 25-44 tahun, tipe multibasiler dengan reaksi erythema nodosum leprosum (ENL). Morbus Hansen (MH) still becomes one of the neglected tropical diseases, including in Indonesia where the prevalence ranks third in the world. This retrospective descriptive study was conducted to describe the profile of MH patients at the Dernatovenerology Clinic, Bali Mandara General Hospital. There were 55 MH patients with 492 (1,6%) visits from 30587 total visits during January 2018-December 2020. This 55 MH patients consisted of 39 (71%) males dan 16 (29%) females, the dominant age group was 25-44 year-old (45,5%). Based on the type of MH, 92,7% were Multibacillary (MB) type reaction and 14,5% were erythema nodosum leprosum (ENL) reaction. The majority of MH patients at the Dermatovenerology Clinic, Bali Mandara General Hospital, were male, 25-44 year-old, multibacillary type with erythema nodosum leprosum (ENL) reaction.
Dermatosis Mengancam Jiwa: Sindrom Stevens-Johnson Diduga Akibat Methampyron Wisan, Angel Benny; Aviana, Felicia
Cermin Dunia Kedokteran Vol 49 No 8 (2022): Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i8.272

Abstract

Sindrom Stevens-Johnson (SSJ) merupakan salah satu dermatosis yang mengancam jiwa dan merupakan bagian dari nekrolisis epidermal (NE), ditandai dengan reaksi mukokutan akut disertai nekrosis luas dan pengelupasan epidermis serta epitel mukosa. Kasus. Laki-laki usia 20 tahun dengan keluhan timbul ruam-ruam kemerahan sejak 2 hari di wajah, menyebar ke leher, dada, perut, punggung, kedua tangan, dan skrotum; diikuti bibir bengkak dan gelembung yang pecah meninggalkan bekas kehitaman. Diduga keluhan muncul setelah pasien mengonsumsi methampyron. Pasien memiliki riwayat systemic lupus erythematosus (SLE) terkontrol. Status dermatologi didapatkan purpura disertai bula dinding kendur pada regio coli, thorax, manus dekstra dan sinistra, dan abdomen. Tanda Nikolsky (+). Pada regio skrotum terdapat bula dinding kendur multipel dan sebagian erosi. Di regio labialis terdapat krusta merah kehitaman multipel, tebal, sulit dilepas, batas irreguler, dan sebagian erosi. Pasien didiagnosis sindrom Stevens-Johnson (SSJ) dan mendapat terapi cairan, methylprednisolone, paracetamol, gentamycin, curcuma, cetirizine, triamcinolone acetonide, desoximetasone, dan chloramphenicol. Pada hari ke-10 perawatan, pasien mengalami perbaikan klinis dan diperbolehkan pulang. Stevens-Johnson syndrome (SJS) is one of the life-threatening dermatoses and a part of epidermal necrolysis (NE), characterized by mucocutaneous reaction, and followed by an extensive necrosis and detachment of epidermis and mucosal epithelium. A 20 year-old man complained of reddish rashes on the face since 2 days ago. The rashes widened and spread to the neck, body, stomach, back, both hands, and scrotum, followed by swollen lips and broken blisters that leave a blackish scar a day later. The symptoms were suspected to develop after taking methampyrone. The patient had a history of controlled Systemic Lupus Erythematosus (SLE). Dermatology status showed purpura and flaccid blisters on the neck, body, back, both hands, and abdomen, Nikolsky sign (+). Multiple flaccid blisters and partial erosion in the scrotum. On the lips, there are multiple reddish-black crusts, thick, hard to remove, irregular border, and partial erosion. The patient was diagnosed with Stevens-Johnson syndrome (SJS) and given fluid therapy, methylprednisolone, paracetamol, gentamicin, curcuma, cetirizine, triamcinolone acetonide, desoximetasone, and chloramphenicol. On the 10th day of the treatment, the patient was clinically improved and was discharged.
Co-Authors Angel Benny Wisan Birawan, I Made Ni Nengah Dwi Fatmawati Sutrini, Ni Nyoman Ayu