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All Journal Jurnal Ilmiah Farmasi Jurnal Penelitian Farmasi Indonesia
Farediah Ahmad
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Decision Sciences, Operations Research & Management Medicine & Pharmacology

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Isolasi Senyawa dan Uji Aktivitas Anti-inflammasi Ekstrak Metanol Daun Puwar Kincung (Nicolaia speciosa Horan) Fernando, Armon; Suryani, Fitri; Ahmad, Farediah; Sirat, Hasnah M.; Arbain, Dayar
Jurnal Penelitian Farmasi Indonesia Vol 1, No 01 (2013)
Publisher : Jurnal Penelitian Farmasi Indonesia

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The study of anti-inflammatory activity and isolation of the methanolic extract, hexane and ethyl acetate fractions of the leaves of puwarkincung (Nicolaia speciosa Horan) have been done. Isolation was carried out by extraction, fractionation and multiple column chromatographicmethod, followed by recrystallization technique. Two compounds were isolated and labeled as F4 and S3. F4 was derived from n-hexanefraction as yellowish-white crystals (20 mg) with mp. 55–57 oC and S3 from the ethyl acetate fraction (15 mg) as yellow crystals with mp.68–69 oC. Anti-inflammatory activity of methanolic extract using Paw Edema method showed that the dose 250 and 1000mg/kgbw wereactive as anti inflammatory agents.
BIOACTIVE CONSTITUENTS FROM THE LEAVES OF MELASTOMA MALABATHRICUM L. Deni Susanti; Hasnah M. Sirat; Farediah Ahmad; Rasadah Mat Ali
Jurnal Ilmiah Farmasi Vol. 5 No. 1 (2008)
Publisher : Universitas Islam Indonesia

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ABSTRACTPhytochemical and bioactivity studies of the leaves of Melastoma malabathricum L.(Melastomataceae) have been investigated. The n-hexane extract yielded -amyrin, patriscabatrineand auranamide, ethyl acetate extract gave quercetin and quercitrin, and methanol extract gavequercitrin and kaempferol-3-O-(2”,6”-di-O-p-trans-coumaroyl)glucoside. The crude extracts andisolated compounds were screened for their antioxidant and cytotoxic activities. The antioxidantassay was carried out by FTC and DPPH radical scavenging method. Kaempferol-3-O-(2”,6”-di-Op-trans-coumaroyl)-glucoside, quercetin and quercitrin showed strong activities with inhibition morethan 90% in the FTC method. Quercetin was found to be the most active as radical scavenger inDPPH method with IC50 of 0.69 M. -Amyrin and kaempferol-3-O-(2”,6”-di-O-p-transcoumaroyl)glucoside demonstrated the strongest activities in the anti-inflammatory assay of TPAmouse ear oedema with IC50 of 0.11 and 0.34 mM/ear, respectively.Keywords: Antiinflammatory, Antioxidant, Flavonoids, Melastomataceae, Melastomamalabathricum, Terpenoid
Co-Authors Armon Fernando DAYAR ARBAIN Deni Susanti Fitri Suryani Hasnah M. Sirat Hasnah M. Sirat Rasadah Mat Ali