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-, Tommy
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Angina Prinzmetal - Diagnosis dan Tatalaksana -, Tommy
Cermin Dunia Kedokteran Vol 48, No 6 (2021): Kardiologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.49 KB) | DOI: 10.55175/cdk.v48i6.1431

Abstract

Angina Prinzmetal merupakan sindrom klinis yang dicirikan dengan nyeri dada saat istirahat disertai perubahan elektrokardiogram. Insidensi lebih tinggi pada populasi Asia dengan rentang usia di atas 50 tahun. Merokok dan penggunaan obat-obatan tertentu dapat meningkatkan risiko angina Prinzmetal. Penyakit ini jarang terdiagnosis sehingga tatalaksana belum optimal. Diagnosis berdasarkan kriteria Coronary Vasomotion Disorders International Study Group dan pemeriksaan penunjang seperti elektrokardiografi, uji provokatif, atau pencitraan intrakoroner. Tatalaksana mencakup perubahan gaya hidup, terapi farmaka, atau intervensi koroner perkutan. Prognosis mengacu pada hasil skor risiko Japanese Coronary Spasm Association, umumnya baik.Prinzmetal’s angina is a clinical syndrome in which angina occurs at rest with transient electrocardiogram changes. The incidence is higher in the Asian population with age ranges above 50 years. Smoking and use of certain drugs can increase the risk of Prinzmetal’s angina. This disease is underdiagnosed and the treatment is not optimal. Diagnosis is based on the Coronary Vasomotion Disorders International Study Group Criteria and supporting examinations such as electrocardiography, provocative test, or intracoronary imaging. The management includes lifestyle changes, pharmacotherapy, or percutaneous coronary intervention. Prognosis refers to the Japanese Coronary Spasm Association risk score, are generally good.
Hipertensi Esensial : Diagnosis dan Tatalaksana Terbaru pada Dewasa Adrian, Steven Johanes; -, Tommy
Cermin Dunia Kedokteran Vol 46, No 3 (2019): Nutrisi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (750.884 KB) | DOI: 10.55175/cdk.v46i3.503

Abstract

Hipertensi merupakan salah satu penyebab terbesar morbiditas penyakit di dunia; penderita hipertensi diperkirakan akan mencapai 1,5 miliar pada tahun 2025 dan kematian dapat mencapai 9,4 juta individu. Hipertensi didefinisikan sebagai kondisi tekanan darah sistolik ≥ 130 mm Hg atau diastolik ≥ 80 mm Hg; 80 – 95% kasus hipertensi esensial. Dua faktor utama berkaitan dengan kasus hipertensi esensial adalah faktor genetik dan lingkungan. Tatalaksana kombinasi non farmakologis dan farmakologis dengan mempertimbangkan berbagai aspek seperti stadium hipertensi, saat mulai pengobatan, jenis obat, target tekanan darah, komorbiditas, kontrol berkala, dan kriteria rujukan.Hypertension causes a considerable morbidity in the world. There will be 1.5 billion hypertensive patients with mortality up to 9.4 million in 2025. Hypertension is defined as systolic blood pressure ≥130 mm Hg or diastolic blood pressure ≥ 80 mm Hg. Approximately 80-95% cases are essential hypertension. The most important factors associated with essential hypertension are genetic and environmental factors. The recommended treatment consists of pharmacological and non-pharmacological methods, considering the stage of hypertension, initiation, class of drugs, blood pressure target, comorbidities, follow-up, and referral criteria.
Potensi Thioridazine Terenkapsulasi Nanopartikel Poly (Lactic-Co-Glycolic) Acid (PLGA) sebagai Inovasi Terapi Baru dalam Tatalaksana TB Resistan Obat Adrian, Steven Johanes; -, Tommy
Cermin Dunia Kedokteran Vol 46, No 11 (2019): Kesehatan Anak
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i11.414

Abstract

Tuberkulosis (TB) adalah penyakit infeksi dengan tingkat kematian tertinggi kedua secara global. Sebanyak 1,4 juta kematian terjadi pada tahun 2015. TB-Multi Drugs Resistance (TB-MDR) menyebabkan 200.000 kematian. Prevalensi TB resistan obat yang tinggi membutuhkan tatalaksana baru yang efektif dan efisien. Penggunaan Thioridazine pada penderita TB resistan obat memberikan perbaikan dan dapat ditoleransi dengan baik. Thioridazine menghambat ekspresi berlebihan pompa efflux pada sel sehingga obat-obatan TB yang sebelumnya telah resistan dapat bekerja kembali. Teknologi nanopartikel dapat digunakan untuk membawa obat sehingga lebih efektif dan efisien. Poly (lactic-co-glycolic) acid (PLGA) adalah salah satu nanopartikel yang telah disetujui oleh Food and Drug Administration (FDA). Penelitian menggunakan model larva zebrafish menunjukkan penggunaan Thioridazine terenkapsulasi PLGA meningkatkan kemampuan Rifampisin dalam mengeliminasi bakteri M.tuberculosis dan M.bovis sebanyak 6,3-7 kali. Penggunaan PLGA juga mengurangi efek samping dari Thioridazine yang berbahaya seperti kardiotoksisitas. Thioridazine terenkapsulasi PLGA sebagai tatalaksana terhadap TB resistan obat mampu memberikan perbaikan yang signifikan terhadap subjek penelitian, sehingga dapat dijadikan sebagai terapi potensial dalam kasus TB resistan obat di Indonesia, namun dibutuhkan penelitian lebih lanjut tentang penggunaannya terutama karena masih terbatasnya studi atau penelitian klinis di Indonesia.Tuberculosis (TB) is an infectious disease with the second highest mortality rate in the world. There were 1,4 million deaths in 2015. Multi-Drug Resistance Tuberculosis (MDR-TB) causes 200.000 deaths. High prevalence of drug resistant-TB needs a novel therapy which is effective and efficient. The use of Thioridazine on drug resistant TB reduce morbidity and well tolerated. Thioridazine inhibits the excessive expression of cellular efflux pump, so the resistant TB drugs can function. Nanoparticle technology can be used to as drug carrier. Poly (lactic-co-glycolic) acid (PLGA) is one of the nanoparticle approved by Food and Drug Administration (FDA). Studies used zebrafish larva model showed the use of Thioridazine encapsulated by PLGA increased the ability of Rifampicin in eliminating M. tuberculosis and M. bovis 6,3-7 times. The use of PLGA also reduced the dangerous side effects of Thioridazine such as cardiotoxicity. Thioridazine encapsulated by PLGA as the treatment for drug-resistant can significantly improve the subject, thus it can be used as a potential treatment for drug-resistant TB. More studies about the use of the drug are needed because the studies are limited.
PERTANGGUNGJAWABAN NOTARIS PEMEGANG PROTOKOL TERHADAP KEABSAHAN AKTA NOTARIS TERKAIT DUGAAN ADANYA KESALAHAN DI DALAM MINUTA AKTA YANG DITERIMANYA (Studi Putusan Mahkamah Agung Republik Indonesia Nomor 1791 K/Pdt/2022) -, Tommy; -, Tony; Sembiring, Rosnidar; -, Suprayitno
Ilmu Hukum Prima (IHP) Vol. 7 No. 1 (2024): JURNAL ILMU HUKUM PRIMA
Publisher : jurnal.unprimdn.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jihp.v7i1.4962

Abstract

The plaintiff in the Supreme Court's decision Number 1791 K/Pdt/2022 sued the Notary public, holding the protocol as the defendant. The object of the lawsuit in the Supreme Court's decision is the Notary's deed in the Notary public protocol, which was received by the Notary public holding the protocol. The plaintiff disputed the error in the Notary's deed. Based on expert opinion, the Notary public who did the deed is responsible for the Notary's deed in the protocol, but the Notary who did the deed died. The Notary public holding the protocol is responsible for storing and maintaining the Notary public protocol he receives, but the Notary public holding the protocol was sued in the decision. This research uses normative legal research, which is descriptive and analytical in nature. The data source used is library data. The data collection technique and tool used is library research. This research analyzes data qualitatively. Based on Article 65 of the Law of Notary Public, the Notary public who makes the deed is responsible for the minutes of the deed he had made even though the minutes of the deed had been handed over to the Notary public holding the protocol. The Notary public holding the protocol is not responsible if there is a lawsuit regarding the contents of the minutes of the deed contained in the protocol he received. The Supreme Court's decision concerns Notary public matters, only considering the lawsuit as lacking parties.
PERTANGGUNGJAWABAN NOTARIS PEMEGANG PROTOKOL TERHADAP KEABSAHAN AKTA NOTARIS TERKAIT DUGAAN ADANYA KESALAHAN DI DALAM MINUTA AKTA YANG DITERIMANYA (Studi Putusan Mahkamah Agung Republik Indonesia Nomor 1791 K/Pdt/2022) -, Tommy; -, Tony; Sembiring, Rosnidar; -, Suprayitno
Ilmu Hukum Prima (IHP) Vol. 7 No. 1 (2024): JURNAL ILMU HUKUM PRIMA
Publisher : jurnal.unprimdn.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jihp.v7i1.4962

Abstract

The plaintiff in the Supreme Court's decision Number 1791 K/Pdt/2022 sued the Notary public, holding the protocol as the defendant. The object of the lawsuit in the Supreme Court's decision is the Notary's deed in the Notary public protocol, which was received by the Notary public holding the protocol. The plaintiff disputed the error in the Notary's deed. Based on expert opinion, the Notary public who did the deed is responsible for the Notary's deed in the protocol, but the Notary who did the deed died. The Notary public holding the protocol is responsible for storing and maintaining the Notary public protocol he receives, but the Notary public holding the protocol was sued in the decision. This research uses normative legal research, which is descriptive and analytical in nature. The data source used is library data. The data collection technique and tool used is library research. This research analyzes data qualitatively. Based on Article 65 of the Law of Notary Public, the Notary public who makes the deed is responsible for the minutes of the deed he had made even though the minutes of the deed had been handed over to the Notary public holding the protocol. The Notary public holding the protocol is not responsible if there is a lawsuit regarding the contents of the minutes of the deed contained in the protocol he received. The Supreme Court's decision concerns Notary public matters, only considering the lawsuit as lacking parties.
Co-Authors -, Tony Adrian, Steven Johanes Rosnidar Sembiring Suprayitno -