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Dermal Filler Trisnarizki, Leonardo; Negara, Wisuda Putra; Mochtar, Moerbono; Julianto, Indah; Mawardi, Prasetyadi
Cermin Dunia Kedokteran Vol 46, No 9 (2019): Neuropati
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (674.405 KB) | DOI: 10.55175/cdk.v46i9.433

Abstract

Penggunaan filler untuk salah satu terapi rejuvenasi modern wajah banyak dilakukan di bidang dermatologi dan makin populer karena aman, efektif dan minimal invasif. Saat ini tersedia berbagai jenis filler yang bervariasi dalam durasi, kegunaan, potensi alergenik, keamanan dan cara aplikasi.The use of filler as one of the modern face rejuvenation therapies is widely performed in dermatology and become popular because it is safe, effective and minimally invasive. Various types of fillers are available, varying in duration, use, allergenic potential, safety and application mode.
Analysis of Factors Influencing Risky Sexual Behavior among Male Students Trisnarizki, Leonardo; Tampubolon, Rifatolistia; Nusawakan, Arwyn Weynand; Letelay, Pieter Bleriof
Journal of Language and Health Vol 5 No 2 (2024): Journal of Language and Health
Publisher : CV. Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jlh.v5i2.4018

Abstract

The adolescent period is characterized by rapid growth and development, which often promotes curiosity and a quest for challenges. This lack of knowledge often results in risky sexual behaviors, which are sexual acts that can lead to pregnancy outside of marriage or sexually transmitted diseases. This study aims to identify the relationship between the role of parents, the use of information media, social norms, religion, and knowledge with risky sexual behavior in male students of Satya Wacana Christian University. This study uses a quantitative method with a cross sectional approach on male students aged 18-24 years at Satya Wacana Christian University, with 372 respondents selected using quota sampling technique. Data were collected using a questionnaire that covered various factors related to risky sexual behavior, such as parental role factors, knowledge, religion, media use, and social norms. All data were analyzed using univariate and bivariate analysis A significant relationship was not found between the role of parents, the use of information media, social norms, and knowledge with risky sexual behavior. However, there was a significant relationship between religious factors and risky sexual behavior, with a p value of 0.001. This study is hopefully able to provide a reference for further research, especially in the context of qualitative research.
Chronic Myeloid Leukemia (CML) in A 14-Year-Old Halim, Catherine; Trisnarizki, Leonardo; Sisca, Sisca
Jurnal Indonesia Sosial Sains Vol. 7 No. 5 (2026): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v7i5.2328

Abstract

Chronic Myeloid Leukemia (CML) is a myeloproliferative disorder accounting for approximately 2-3% of leukemias in children and adolescents, with an annual incidence of 1 in 1,000,000 individuals (approximately 10% of all CML cases). The median age of onset in children is 11-12 years. CML is caused by a reciprocal translocation of genes on chromosomes 9 and 22, resulting in the formation of the Breakpoint Cluster Region (BCR) gene on chromosome 22 with the Abelson leukemia virus (ABL) gene. The BCR-ABL protein has constitutive tyrosine kinase activity, leading to the activation of intracellular signal transduction pathways such as STAT, RAS, JUN, MYC, and Phosphatidylinositol-3 kinase. This case report concerns a 14-year-old girl with CML, a rare hematologic malignancy in children. The patient presented with abdominal enlargement and hardening for 2 months, abdominal pain, fever, and vomiting. Physical examination revealed splenomegaly (Schuffner 4). Laboratory tests revealed anemia (hemoglobin 7.3 g/dL) and leukocytosis (291,890 WBCs/mm³). Peripheral blood smear showed myeloid blasts and all stages of granulocyte maturation with basophilia and eosinophilia. Bone marrow aspiration confirmed chronic myeloid leukemia in the chronic phase with an M/E ratio of 25.5. BCR-ABL molecular testing revealed positive fusion of B2A2 and B3A2. This case highlights the aggressive presentation of pediatric CML characterized by massive splenomegaly and extreme leukocytosis, which differs from adult CML. Early recognition and timely diagnosis are essential to prevent disease progression and life-threatening complications such as leukostasis, bleeding, and splenic rupture.